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Q4KC80

- ARNT1_PSEF5

UniProt

Q4KC80 - ARNT1_PSEF5

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Protein

Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 1

Gene

arnT1

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. mannosyltransferase activity Source: JCVI
  2. transferase activity, transferring pentosyl groups Source: InterPro

GO - Biological processi

  1. lipid A biosynthetic process Source: JCVI
  2. lipopolysaccharide biosynthetic process Source: UniProtKB-KW
  3. mannosylation Source: GOC
  4. protein O-linked glycosylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-3061-MONOMER.
UniPathwayiUPA00037.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 1UniRule annotation (EC:2.4.2.43UniRule annotation)
Alternative name(s):
4-amino-4-deoxy-L-arabinose lipid A transferase 1UniRule annotation
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferaseUniRule annotation
Undecaprenyl phosphate-alpha-L-Ara4N transferase 1UniRule annotation
Gene namesi
Name:arnT1UniRule annotation
Ordered Locus Names:PFL_3047
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008540: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 1PRO_0000380019Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220664.PFL_3047.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalUniRule annotationAdd
BLAST
Transmembranei80 – 10223HelicalUniRule annotationAdd
BLAST
Transmembranei112 – 13221HelicalUniRule annotationAdd
BLAST
Transmembranei133 – 15321HelicalUniRule annotationAdd
BLAST
Transmembranei176 – 19621HelicalUniRule annotationAdd
BLAST
Transmembranei204 – 22421HelicalUniRule annotationAdd
BLAST
Transmembranei257 – 27721HelicalUniRule annotationAdd
BLAST
Transmembranei290 – 31021HelicalUniRule annotationAdd
BLAST
Transmembranei312 – 33221HelicalUniRule annotationAdd
BLAST
Transmembranei342 – 36221HelicalUniRule annotationAdd
BLAST
Transmembranei377 – 39721HelicalUniRule annotationAdd
BLAST
Transmembranei402 – 42221HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 83 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1807.
HOGENOMiHOG000273002.
KOiK07264.
OMAiGNWIAPH.
OrthoDBiEOG6NKQWN.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer.
InterProiIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39.
[Graphical view]
PfamiPF02366. PMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KC80-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRRWALPLL LIAFGLFYLL PLATHGLWIP DETRYAQISQ EMLLTGKWAS
60 70 80 90 100
PHFMGIRYFE KPVAGYWMIA IGQALFGDNL FGVRVASALS TGLSVVLAYL
110 120 130 140 150
LARRLWNDPR KSLASALLYM SFTVVALQAG YANLDPQFTF WVNLSLVALW
160 170 180 190 200
FTFDCRTTRG QVLAWVALGL ACGMGFMTKG FLAWLLPVLV ALPYAIWQKR
210 220 230 240 250
LRSLLIYGGI GVLVAILISL PWALAVHSQE PDYWRFFFWH EHIRRFAGDD
260 270 280 290 300
AQHASPWWYY LPLLVGFSVP WVLLLPAGLK QAWQQRRQNS SGFLLLWLVL
310 320 330 340 350
PLAFFSLSKG KLPAYILPCL LPLALLMGNT LVDRLAAGKT RLLAFNGVLN
360 370 380 390 400
LVAGLLGLLA LVYFQMKKPV YVDEPQHLVL VYVLLLGWIL SNLLQAMRPL
410 420 430 440 450
TLWAAPALGS FLLVALAPAA LPNSVVYNKI PDQFIIDHVA ELGQAKALLS
460 470 480 490 500
NDLGAASALA WRLRRPDVTL YNTEGEVKYG LGYEDTAARK VDLNQVQPWI
510 520 530 540
AEARKQGSIG VVMRVKSSDE EHEVELLPKD AKRYEQGNIV IFIIPQSQP
Length:549
Mass (Da):61,527
Last modified:August 2, 2005 - v1
Checksum:iB502E6C18E10B019
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY92317.1.
RefSeqiYP_260153.1. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY92317; AAY92317; PFL_3047.
GeneIDi3475940.
KEGGipfl:PFL_3047.
PATRICi19875405. VBIPseFlu72549_3107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY92317.1 .
RefSeqi YP_260153.1. NC_004129.6.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220664.PFL_3047.

Protein family/group databases

CAZyi GT83. Glycosyltransferase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY92317 ; AAY92317 ; PFL_3047 .
GeneIDi 3475940.
KEGGi pfl:PFL_3047.
PATRICi 19875405. VBIPseFlu72549_3107.

Phylogenomic databases

eggNOGi COG1807.
HOGENOMi HOG000273002.
KOi K07264.
OMAi GNWIAPH.
OrthoDBi EOG6NKQWN.

Enzyme and pathway databases

UniPathwayi UPA00037 .
BioCyci PFLU220664:GIX8-3061-MONOMER.

Family and domain databases

HAMAPi MF_01165. ArnT_transfer.
InterProi IPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39.
[Graphical view ]
Pfami PF02366. PMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiARNT1_PSEF5
AccessioniPrimary (citable) accession number: Q4KC80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: August 2, 2005
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3