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Protein

Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 1

Gene

arnT1

Organism
Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate.UniRule annotation

Pathwayi: 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis

This protein is involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis, which is part of Lipopolysaccharide metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis and in Lipopolysaccharide metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00037.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 1UniRule annotation (EC:2.4.2.43UniRule annotation)
Alternative name(s):
4-amino-4-deoxy-L-arabinose lipid A transferase 1UniRule annotation
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferaseUniRule annotation
Undecaprenyl phosphate-alpha-L-Ara4N transferase 1UniRule annotation
Gene namesi
Name:arnT1UniRule annotation
Ordered Locus Names:PFL_3047
OrganismiPseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000008540 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 102HelicalUniRule annotationAdd BLAST23
Transmembranei112 – 132HelicalUniRule annotationAdd BLAST21
Transmembranei133 – 153HelicalUniRule annotationAdd BLAST21
Transmembranei176 – 196HelicalUniRule annotationAdd BLAST21
Transmembranei204 – 224HelicalUniRule annotationAdd BLAST21
Transmembranei257 – 277HelicalUniRule annotationAdd BLAST21
Transmembranei290 – 310HelicalUniRule annotationAdd BLAST21
Transmembranei312 – 332HelicalUniRule annotationAdd BLAST21
Transmembranei342 – 362HelicalUniRule annotationAdd BLAST21
Transmembranei377 – 397HelicalUniRule annotationAdd BLAST21
Transmembranei402 – 422HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003800191 – 549Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 1Add BLAST549

Interactioni

Protein-protein interaction databases

STRINGi220664.PFL_3047.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 83 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105SA9. Bacteria.
COG1807. LUCA.
HOGENOMiHOG000273002.
KOiK07264.
OMAiISAPWAI.
OrthoDBiPOG091H00H0.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer. 1 hit.
InterProiIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39/83.
[Graphical view]
PfamiPF02366. PMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KC80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRRWALPLL LIAFGLFYLL PLATHGLWIP DETRYAQISQ EMLLTGKWAS
60 70 80 90 100
PHFMGIRYFE KPVAGYWMIA IGQALFGDNL FGVRVASALS TGLSVVLAYL
110 120 130 140 150
LARRLWNDPR KSLASALLYM SFTVVALQAG YANLDPQFTF WVNLSLVALW
160 170 180 190 200
FTFDCRTTRG QVLAWVALGL ACGMGFMTKG FLAWLLPVLV ALPYAIWQKR
210 220 230 240 250
LRSLLIYGGI GVLVAILISL PWALAVHSQE PDYWRFFFWH EHIRRFAGDD
260 270 280 290 300
AQHASPWWYY LPLLVGFSVP WVLLLPAGLK QAWQQRRQNS SGFLLLWLVL
310 320 330 340 350
PLAFFSLSKG KLPAYILPCL LPLALLMGNT LVDRLAAGKT RLLAFNGVLN
360 370 380 390 400
LVAGLLGLLA LVYFQMKKPV YVDEPQHLVL VYVLLLGWIL SNLLQAMRPL
410 420 430 440 450
TLWAAPALGS FLLVALAPAA LPNSVVYNKI PDQFIIDHVA ELGQAKALLS
460 470 480 490 500
NDLGAASALA WRLRRPDVTL YNTEGEVKYG LGYEDTAARK VDLNQVQPWI
510 520 530 540
AEARKQGSIG VVMRVKSSDE EHEVELLPKD AKRYEQGNIV IFIIPQSQP
Length:549
Mass (Da):61,527
Last modified:August 2, 2005 - v1
Checksum:iB502E6C18E10B019
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY92317.1.
RefSeqiWP_011061335.1. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY92317; AAY92317; PFL_3047.
GeneIDi3475940.
KEGGipfl:PFL_3047.
PATRICi19875405. VBIPseFlu72549_3107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY92317.1.
RefSeqiWP_011061335.1. NC_004129.6.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220664.PFL_3047.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY92317; AAY92317; PFL_3047.
GeneIDi3475940.
KEGGipfl:PFL_3047.
PATRICi19875405. VBIPseFlu72549_3107.

Phylogenomic databases

eggNOGiENOG4105SA9. Bacteria.
COG1807. LUCA.
HOGENOMiHOG000273002.
KOiK07264.
OMAiISAPWAI.
OrthoDBiPOG091H00H0.

Enzyme and pathway databases

UniPathwayiUPA00037.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer. 1 hit.
InterProiIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39/83.
[Graphical view]
PfamiPF02366. PMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARNT1_PSEF5
AccessioniPrimary (citable) accession number: Q4KC80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: August 2, 2005
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.