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Q4KC80 (ARNT1_PSEF5) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 1

EC=2.4.2.43
Alternative name(s):
4-amino-4-deoxy-L-arabinose lipid A transferase 1
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
Undecaprenyl phosphate-alpha-L-Ara4N transferase 1
Gene names
Name:arnT1
Ordered Locus Names:PFL_3047
OrganismPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP]
Taxonomic identifier220664 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides By similarity. HAMAP-Rule MF_01165

Catalytic activity

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate. HAMAP-Rule MF_01165

Pathway

Lipopolysaccharide metabolism; 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis. HAMAP-Rule MF_01165

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01165.

Sequence similarities

Belongs to the glycosyltransferase 83 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 1 HAMAP-Rule MF_01165
PRO_0000380019

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane80 – 10223Helical; Potential
Transmembrane112 – 13221Helical; Potential
Transmembrane133 – 15321Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane204 – 22421Helical; Potential
Transmembrane257 – 27721Helical; Potential
Transmembrane290 – 31021Helical; Potential
Transmembrane312 – 33221Helical; Potential
Transmembrane342 – 36221Helical; Potential
Transmembrane377 – 39721Helical; Potential
Transmembrane402 – 42221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q4KC80 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: B502E6C18E10B019

FASTA54961,527
        10         20         30         40         50         60 
MTRRWALPLL LIAFGLFYLL PLATHGLWIP DETRYAQISQ EMLLTGKWAS PHFMGIRYFE 

        70         80         90        100        110        120 
KPVAGYWMIA IGQALFGDNL FGVRVASALS TGLSVVLAYL LARRLWNDPR KSLASALLYM 

       130        140        150        160        170        180 
SFTVVALQAG YANLDPQFTF WVNLSLVALW FTFDCRTTRG QVLAWVALGL ACGMGFMTKG 

       190        200        210        220        230        240 
FLAWLLPVLV ALPYAIWQKR LRSLLIYGGI GVLVAILISL PWALAVHSQE PDYWRFFFWH 

       250        260        270        280        290        300 
EHIRRFAGDD AQHASPWWYY LPLLVGFSVP WVLLLPAGLK QAWQQRRQNS SGFLLLWLVL 

       310        320        330        340        350        360 
PLAFFSLSKG KLPAYILPCL LPLALLMGNT LVDRLAAGKT RLLAFNGVLN LVAGLLGLLA 

       370        380        390        400        410        420 
LVYFQMKKPV YVDEPQHLVL VYVLLLGWIL SNLLQAMRPL TLWAAPALGS FLLVALAPAA 

       430        440        450        460        470        480 
LPNSVVYNKI PDQFIIDHVA ELGQAKALLS NDLGAASALA WRLRRPDVTL YNTEGEVKYG 

       490        500        510        520        530        540 
LGYEDTAARK VDLNQVQPWI AEARKQGSIG VVMRVKSSDE EHEVELLPKD AKRYEQGNIV 


IFIIPQSQP 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000076 Genomic DNA. Translation: AAY92317.1.
RefSeqYP_260153.1. NC_004129.6.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220664.PFL_3047.

Protein family/group databases

CAZyGT83. Glycosyltransferase Family 83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY92317; AAY92317; PFL_3047.
GeneID3475940.
KEGGpfl:PFL_3047.
PATRIC19875405. VBIPseFlu72549_3107.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1807.
HOGENOMHOG000273002.
KOK07264.
OMAGNWIAPH.
OrthoDBEOG6NKQWN.

Enzyme and pathway databases

BioCycPFLU220664:GIX8-3061-MONOMER.
UniPathwayUPA00037.

Family and domain databases

HAMAPMF_01165. ArnT_transfer.
InterProIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39.
[Graphical view]
PfamPF02366. PMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARNT1_PSEF5
AccessionPrimary (citable) accession number: Q4KC80
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: August 2, 2005
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways