ID   NUDC_PSEF5              Reviewed;         276 AA.
AC   Q4KBL2;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=NADH pyrophosphatase;
DE            EC=3.6.1.22;
GN   Name=nudC; OrderedLocusNames=PFL_3266;
OS   Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=220664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15980861; DOI=10.1038/nbt1110;
RA   Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A.,
RA   Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J.,
RA   Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A.,
RA   Rosovitz M.J., Gwinn M.L., Zhou L., Schneider D.J., Cartinhour S.W.,
RA   Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A.,
RA   Pierson L.S. III, Thomashow L.S., Loper J.E.;
RT   "Complete genome sequence of the plant commensal Pseudomonas
RT   fluorescens Pf-5.";
RL   Nat. Biotechnol. 23:873-878(2005).
CC   -!- CATALYTIC ACTIVITY: NAD(+) + H(2)O = AMP + NMN.
CC   -!- COFACTOR: Divalent ions. Manganese or magnesium (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. NudC subfamily.
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DR   EMBL; CP000076; AAY92535.1; -; Genomic_DNA.
DR   RefSeq; YP_260371.1; -.
DR   GeneID; 3477808; -.
DR   GenomeReviews; CP000076_GR; PFL_3266.
DR   KEGG; pfl:PFL_3266; -.
DR   NMPDR; fig|220664.3.peg.4539; -.
DR   HOGENOM; Q4KBL2; -.
DR   OMA; Q4KBL2; TWAREHR.
DR   BioCyc; PFLU220664:PFL_3266-MON; -.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:HAMAP.
DR   GO; GO:0000210; F:NAD+ diphosphatase activity; IEA:HAMAP.
DR   HAMAP; MF_00297; -; 1.
DR   InterPro; IPR015375; NADH_PPase-like_N.
DR   InterPro; IPR000086; NUDIX_hydrolase_core.
DR   InterPro; IPR015376; Znr_NADH_PPase.
DR   Gene3D; G3DSA:3.90.79.10; NUDIX_hydrolase; 1.
DR   Pfam; PF00293; NUDIX; 1.
DR   Pfam; PF09296; NUDIX-like; 1.
DR   Pfam; PF09297; zf-NADH-PPase; 1.
DR   PROSITE; PS00893; NUDIX; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Magnesium; Manganese; NAD.
FT   CHAIN         1    276       NADH pyrophosphatase.
FT                                /FTId=PRO_0000232117.
FT   MOTIF       173    194       Nudix box.
SQ   SEQUENCE   276 AA;  30708 MW;  923F7D9BA54595DB CRC64;
     MIERWTTAVL DTDLPGGWAV ARGPDGFLYD DNGALFPRHW LKGQDLPLLA EHGIGHLDGE
     PVYLLELSAR AEVPGCGWKG LRAFMLEGDH TLYKVLGYAA QIGTWAREHR YCGSCGRPMA
     QVPGERAMYC QPCDLRSYPR ISPSMIVLIT RGDEILLARS PRFVTGVYST LAGFAEPGES
     AEDCLIREVR EEVSIEVRNI QYVGSQCWPF PHSMMLGFHA EYAGGEIIPQ EDEIEDAQWF
     SVHALPPLPA SRSIARYLID LYVARRLGHA EPVLPG
//