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Protein

2-aminoethylphosphonate--pyruvate transaminase

Gene

phnW

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in phosphonate degradation.UniRule annotation

Catalytic activityi

(2-aminoethyl)phosphonate + pyruvate = 2-phosphonoacetaldehyde + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate, Pyruvate

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-3999-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-aminoethylphosphonate--pyruvate transaminaseUniRule annotation (EC:2.6.1.37UniRule annotation)
Alternative name(s):
2-aminoethylphosphonate aminotransferaseUniRule annotation
AEP transaminaseUniRule annotation
Short name:
AEPTUniRule annotation
Gene namesi
Name:phnWUniRule annotation
Ordered Locus Names:PFL_3965
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000008540 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3693692-aminoethylphosphonate--pyruvate transaminasePRO_0000286776Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei193 – 1931N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi220664.PFL_3965.

Structurei

3D structure databases

ProteinModelPortaliQ4K9L8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107STF. Bacteria.
COG0075. LUCA.
HOGENOMiHOG000171816.
KOiK03430.
OMAiTWDDEYN.
OrthoDBiEOG6C5RKJ.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01376. PhnW_aminotrans_5.
InterProiIPR000192. Aminotrans_V_dom.
IPR012703. NH2EtPonate_pyrv_transaminase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR024169. SP_NH2Trfase/AEP_transaminase.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000524. SPT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03301. PhnW-AepZ. 1 hit.
TIGR02326. transamin_PhnW. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4K9L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIAEPILLT PGPLTTSART RQAMLVDWGS WDDRFNQLTA SLCQQLLAII
60 70 80 90 100
QGADSHHCVP LQGSGTFAVE AAIGTLVPRD GKVLVLINGA YGKRLAKICE
110 120 130 140 150
VLGRDFSTFE TAEDQPTTAA DVERLLQADS SISHVALIHC ETSTGILNPL
160 170 180 190 200
PEIAQVVASH GKRLIIDAMS SFGALPIDAR EIPFDALIAA SGKCLEGVPG
210 220 230 240 250
MGFVFAAKAS LAQAGGNAHS LAMDLHDQHS YMAKTGQWRF TPPTHVVAAL
260 270 280 290 300
HEALLQYAEE GGLPARHARY ADNCQTLLDG MGELGLRSFL PEAIQAPIIV
310 320 330 340 350
TFHAPKDPRY QFKDFYERVK AKGFILYPGK LTQVETFRVG CIGHVDRRGM
360
QAAVAAIAEV LQEMEVLDI
Length:369
Mass (Da):39,792
Last modified:August 2, 2005 - v1
Checksum:i0B46A707D4D7D743
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY93229.1.
RefSeqiWP_011062252.1. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY93229; AAY93229; PFL_3965.
GeneIDi3477723.
KEGGipfl:PFL_3965.
PATRICi19877321. VBIPseFlu72549_4062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY93229.1.
RefSeqiWP_011062252.1. NC_004129.6.

3D structure databases

ProteinModelPortaliQ4K9L8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220664.PFL_3965.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY93229; AAY93229; PFL_3965.
GeneIDi3477723.
KEGGipfl:PFL_3965.
PATRICi19877321. VBIPseFlu72549_4062.

Phylogenomic databases

eggNOGiENOG4107STF. Bacteria.
COG0075. LUCA.
HOGENOMiHOG000171816.
KOiK03430.
OMAiTWDDEYN.
OrthoDBiEOG6C5RKJ.

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-3999-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01376. PhnW_aminotrans_5.
InterProiIPR000192. Aminotrans_V_dom.
IPR012703. NH2EtPonate_pyrv_transaminase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR024169. SP_NH2Trfase/AEP_transaminase.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000524. SPT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03301. PhnW-AepZ. 1 hit.
TIGR02326. transamin_PhnW. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiPHNW_PSEF5
AccessioniPrimary (citable) accession number: Q4K9L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: August 2, 2005
Last modified: November 11, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.