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Reviewed, UniProtKB/Swiss-Prot Q4K909 (DSBD_PSEF5)

Last modified June 16, 2009. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Thiol:disulfide interchange protein dsbD
    EC=1.8.1.8
Alternative name(s):
    Protein-disulfide reductase
      Short name=Disulfide reductase
Gene names
Name: dsbD
Ordered Locus Names: PFL_4182
OrganismPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP]
Taxonomic identifier220664 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

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Protein attributes

Sequence length583 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps By similarity.

Catalytic activity

Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H. HAMAP MF_00399

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the thioredoxin family. DsbD subfamily.

Contains 1 thioredoxin domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 583565Thiol:disulfide interchange protein dsbD HAMAP MF_00399
PRO_0000304393

Regions

Transmembrane168 – 18821 Potential
Transmembrane214 – 23421 Potential
Transmembrane245 – 26521 Potential
Transmembrane289 – 30921 Potential
Transmembrane326 – 34621 Potential
Transmembrane359 – 37921 Potential
Transmembrane382 – 40221 Potential
Transmembrane413 – 43321 Potential
Domain458 – 581124Thioredoxin

Amino acid modifications

Disulfide bond118 ↔ 124Redox-active By similarity
Disulfide bond186 ↔ 306Redox-active By similarity
Disulfide bond496 ↔ 499Redox-active By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q4K909-1 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: CAEBB141CBA77113

FASTA58362,515
        10         20         30         40         50         60 
MRRLFLLLFM LFTTLAHAGN NPFEVKPDFL PVGKAFVFTS ERLPSGETQL FWQIADGYYL 

        70         80         90        100        110        120 
YQKRLKFDGV APELQPTLPA GEDHSDEFFG QQTVYRQGLE VKLPAAASGK VKLGWQGCAD 

       130        140        150        160        170        180 
AGLCYPPQTL EVDLGGAPAV AASNVATTSN GSAQDQLLAN DLQHKSWGLG LLAFFGFGLL 

       190        200        210        220        230        240 
LAFAPCSLPM LPILAGMVVG SGASPRRGLA LASSYVLCMA LVYAGMGVIA ALLGSNLQAW 

       250        260        270        280        290        300 
LQQPWVLGSF AALFVLLSLP MFGFFELQMP ALLRDRLEGA SRQRQGGSLI GCGILGALSA 

       310        320        330        340        350        360 
LLVGPCMTAP LAGGLLYIAQ TGNALFGGLA LFALGLGIGL PLLLLVTLGN RFLPKPGPWM 

       370        380        390        400        410        420 
NLLKGVFGIL FLGTAIYMLR PVLNPGLWMG LWGALALVVA YCAWQQRAIA GRLLHLFGAG 

       430        440        450        460        470        480 
ALLFAAWGGM LLVGAAGGGD DLWRPLKVYR GGPVANSVTA HDAFTTVKSP AELQGALDSA 

       490        500        510        520        530        540 
RAQGQWVLLD YYADWCVSCK IMEKTVFGQP QVLEALKDVR LLRLDVTLDN ADGRELLSRY 

       550        560        570        580 
KVPGPPSMLW IGPDGSERRS QRITGEVDAN AFLQRWTQTR EAR

« Hide

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Cross-references

Sequence databases

CP000076 Genomic DNA. Translation: AAY93438.1.
RefSeqYP_261274.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3476920.
GenomeReviewsGene locus PFL_4182 in contig CP000076_GR.
KEGGpfl:PFL_4182.
NMPDRfig|220664.3.peg.5994.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ4K909.
OMAQ4K909. HILTIRI.

Enzyme and pathway databases

BioCycPFLU220664:PFL_4182-MON.

Family and domain databases

HAMAPMF_00399.
[Tree]
InterProIPR003834. Cyt_c_assmbl_TM.
IPR017936. Thioredoxin-like.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PfamPF02683. DsbD. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
PROSITEPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDSBD_PSEF5
AccessionPrimary (citable) accession number: Q4K909
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 2, 2005
Last modified: June 16, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents