ID   MSRB_PSEF5              Reviewed;         130 AA.
AC   Q4K8U5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Peptide methionine sulfoxide reductase msrB;
DE            EC=1.8.4.12;
DE   AltName: Full=Peptide-methionine (R)-S-oxide reductase;
GN   Name=msrB; OrderedLocusNames=PFL_4246;
OS   Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=220664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15980861; DOI=10.1038/nbt1110;
RA   Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A.,
RA   Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J.,
RA   Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A.,
RA   Rosovitz M.J., Gwinn M.L., Zhou L., Schneider D.J., Cartinhour S.W.,
RA   Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A.,
RA   Pierson L.S. III, Thomashow L.S., Loper J.E.;
RT   "Complete genome sequence of the plant commensal Pseudomonas
RT   fluorescens Pf-5.";
RL   Nat. Biotechnol. 23:873-878(2005).
CC   -!- CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide +
CC       H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit. The zinc ion is important
CC       for the structural integrity of the protein (By similarity).
CC   -!- SIMILARITY: Belongs to the msrB Met sulfoxide reductase family.
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DR   EMBL; CP000076; AAY93502.1; -; Genomic_DNA.
DR   RefSeq; YP_261338.1; -.
DR   GeneID; 3477372; -.
DR   GenomeReviews; CP000076_GR; PFL_4246.
DR   KEGG; pfl:PFL_4246; -.
DR   NMPDR; fig|220664.3.peg.6058; -.
DR   HOGENOM; Q4K8U5; -.
DR   OMA; Q4K8U5; FTGRYWD.
DR   BioCyc; PFLU220664:PFL_4246-MON; -.
DR   GO; GO:0033743; F:peptide-methionine (R)-S-oxide reductase ac...; IEA:EC.
DR   GO; GO:0008113; F:peptide-methionine-(S)-S-oxide reductase ac...; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01400; -; 1.
DR   InterPro; IPR002579; Methionine_sulphoxide_MsrB.
DR   Gene3D; G3DSA:2.170.150.20; MsrB; 1.
DR   Pfam; PF01641; SelR; 1.
DR   ProDom; PD004057; DUF25; 1.
DR   TIGRFAMs; TIGR00357; MsrB; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Metal-binding; Oxidoreductase; Zinc.
FT   CHAIN         1    130       Peptide methionine sulfoxide reductase
FT                                msrB.
FT                                /FTId=PRO_1000068285.
FT   ACT_SITE    119    119       Nucleophile (By similarity).
FT   METAL        47     47       Zinc (By similarity).
FT   METAL        50     50       Zinc (By similarity).
FT   METAL        96     96       Zinc (By similarity).
FT   METAL        99     99       Zinc (By similarity).
SQ   SEQUENCE   130 AA;  14683 MW;  792C5B2F52FEA8BF CRC64;
     MEKLEKTLEE WRSMLDPEQY NVCRLKGTER PFSGKYNGTK TDGVYHCICC NEPLFDSKAK
     FDSGCGWPSF YEPIADSAMV EIRDMSHGMI RTEVVCAKCD AHLGHVFPDG PPPTGLRYCI
     NSVCLDLVPR
//