Reviewed, UniProtKB/Swiss-Prot Q4K8N0 (HIS82_PSEF5)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 2
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 2

Gene names

Name:	hisC2
Ordered Locus Names:	PFL_4311

Organism

Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP]

Taxonomic identifier

220664 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Histidinol-phosphate aminotransferase 2 HAMAP MF_01023		PRO_0000153420
Amino acid modifications
	Modified residue	230	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4K8N0-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 21FE003953A5637A	FASTA	370	39,894
	10 20 30 40 50 60 MSGDFLALAQ PGVQQLSPYV PGKPVDELAR ELDIDPATIV KLASNENPLG ASPKALAAIR 70 80 90 100 110 120 DELAELTRYP DGNGFALKSL LAERCGVEID QVTLGNGSND ILELVARAYL APGLNAVFSE 130 140 150 160 170 180 HAFAVYPIVT QAVGAQARVV PAKNWGHDLP AMLKAIDDRT RVVFIANPNN PTGTWFGAEE 190 200 210 220 230 240 LDEFLQDVPA HVLVVLDEAY IEYAEGSDLP DGLDFLAAYP NLLVSRTFSK AYGLAALRVG 250 260 270 280 290 300 YGLSTPVVAD VLNRVRQPFN VNSLALAAAC AALEDVDYLA ESRRLNEAGM QQLEAGFRDL 310 320 330 340 350 360 GLRWIPSKGN FIAVDLGREA APIFQELLRE GVIVRPVANY GMPNHLRITI GLPAENTRFL 370 EALAKVLARA

References

[1]

"Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5." Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A., Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J., Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A., Rosovitz M.J., Gwinn M.L., Zhou L. , Schneider D.J., Cartinhour S.W., Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A., Pierson L.S. III, Thomashow L.S., Loper J.E. Nat. Biotechnol. 23:873-878(2005) [PubMed: 15980861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000076 Genomic DNA. Translation: AAY93566.1.
RefSeq	YP_261403.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3478434.
GenomeReviews	Gene locus PFL_4311 in contig CP000076_GR.
KEGG	pfl:PFL_4311.
NMPDR	fig|220664.3.peg.6123.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4K8N0.
OMA	Q4K8N0. KGYIVRS.
Enzyme and pathway databases
BioCyc	PFLU220664:PFL_4311-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR004839. Aminotrans_I/II. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS82_PSEF5

Accession

Primary (citable) accession number: Q4K8N0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	August 2, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)