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Q4K8A5

- PUR5_PSEF5

UniProt

Q4K8A5 - PUR5_PSEF5

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPFLU220664:GIX8-4475-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:PFL_4440
    OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
    Taxonomic identifieri220664 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000008540: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 352352Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258383Add
    BLAST

    2D gel databases

    World-2DPAGE0008:Q4K8A5.

    Interactioni

    Protein-protein interaction databases

    STRINGi220664.PFL_4440.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4K8A5.
    SMRiQ4K8A5. Positions 6-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiEFEMYRT.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4K8A5-1 [UniParc]FASTAAdd to Basket

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    MSKQPSLSYK DAGVDIDAGE ALVERIKSVA KRTARPEVMG GLGGFGALCE    50
    IPAGYKQPVL VSGTDGVGTK LRLALNLNKH DSIGIDLVAM CVNDLVVCGA 100
    EPLFFLDYYA TGKLNVDTAA QVVTGIGAGC ELSGCSLVGG ETAEMPGMYE 150
    GEDYDLAGFC VGVVEKAEII DGSKVAAGDA LLALPSSGPH SNGYSLIRKI 200
    IEVSGADIES IQLDGKPLTD LLMAPTRIYV KPLLKLIKDT GAVKAMAHIT 250
    GGGLLDNIPR VLPKGAQAVV DVASWQRPAV FDWLQEKGNV DEHEMHRVLN 300
    CGVGMVICVA QDQVENALKV LREAGEQPWV IGQIATAAEG AAQVELKNLK 350
    AH 352
    Length:352
    Mass (Da):36,945
    Last modified:August 2, 2005 - v1
    Checksum:i4582142FFD4E1D20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY93691.1.
    RefSeqiYP_261528.1. NC_004129.6.

    Genome annotation databases

    EnsemblBacteriaiAAY93691; AAY93691; PFL_4440.
    GeneIDi3478559.
    KEGGipfl:PFL_4440.
    PATRICi19878312. VBIPseFlu72549_4545.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY93691.1 .
    RefSeqi YP_261528.1. NC_004129.6.

    3D structure databases

    ProteinModelPortali Q4K8A5.
    SMRi Q4K8A5. Positions 6-337.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220664.PFL_4440.

    2D gel databases

    World-2DPAGE 0008:Q4K8A5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY93691 ; AAY93691 ; PFL_4440 .
    GeneIDi 3478559.
    KEGGi pfl:PFL_4440.
    PATRICi 19878312. VBIPseFlu72549_4545.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi EFEMYRT.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci PFLU220664:GIX8-4475-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf-5 / ATCC BAA-477.

    Entry informationi

    Entry nameiPUR5_PSEF5
    AccessioniPrimary (citable) accession number: Q4K8A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3