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Q4K8A5

- PUR5_PSEF5

UniProt

Q4K8A5 - PUR5_PSEF5

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, PFL_4440
Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-4475-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:PFL_4440
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008540: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_0000258383Add
BLAST

2D gel databases

World-2DPAGE0008:Q4K8A5.

Interactioni

Protein-protein interaction databases

STRINGi220664.PFL_4440.

Structurei

3D structure databases

ProteinModelPortaliQ4K8A5.
SMRiQ4K8A5. Positions 6-337.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4K8A5-1 [UniParc]FASTAAdd to Basket

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MSKQPSLSYK DAGVDIDAGE ALVERIKSVA KRTARPEVMG GLGGFGALCE    50
IPAGYKQPVL VSGTDGVGTK LRLALNLNKH DSIGIDLVAM CVNDLVVCGA 100
EPLFFLDYYA TGKLNVDTAA QVVTGIGAGC ELSGCSLVGG ETAEMPGMYE 150
GEDYDLAGFC VGVVEKAEII DGSKVAAGDA LLALPSSGPH SNGYSLIRKI 200
IEVSGADIES IQLDGKPLTD LLMAPTRIYV KPLLKLIKDT GAVKAMAHIT 250
GGGLLDNIPR VLPKGAQAVV DVASWQRPAV FDWLQEKGNV DEHEMHRVLN 300
CGVGMVICVA QDQVENALKV LREAGEQPWV IGQIATAAEG AAQVELKNLK 350
AH 352
Length:352
Mass (Da):36,945
Last modified:August 2, 2005 - v1
Checksum:i4582142FFD4E1D20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY93691.1.
RefSeqiYP_261528.1. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY93691; AAY93691; PFL_4440.
GeneIDi3478559.
KEGGipfl:PFL_4440.
PATRICi19878312. VBIPseFlu72549_4545.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY93691.1 .
RefSeqi YP_261528.1. NC_004129.6.

3D structure databases

ProteinModelPortali Q4K8A5.
SMRi Q4K8A5. Positions 6-337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220664.PFL_4440.

2D gel databases

World-2DPAGE 0008:Q4K8A5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY93691 ; AAY93691 ; PFL_4440 .
GeneIDi 3478559.
KEGGi pfl:PFL_4440.
PATRICi 19878312. VBIPseFlu72549_4545.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci PFLU220664:GIX8-4475-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiPUR5_PSEF5
AccessioniPrimary (citable) accession number: Q4K8A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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