UniProtKB - Q4K884 (ARNT2_PSEF5)
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Protein
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2
Gene
arnT2
Organism
Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Status
Functioni
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation
Catalytic activityi
4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate.UniRule annotation
: 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis Pathwayi
This protein is involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis, which is part of Lipopolysaccharide metabolism.UniRule annotationView all proteins of this organism that are known to be involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis and in Lipopolysaccharide metabolism.
GO - Molecular functioni
- 4-amino-4-deoxy-L-arabinose transferase activity Source: UniProtKB-EC
- mannosyltransferase activity Source: InterPro
GO - Biological processi
- lipid A biosynthetic process Source: UniProtKB-KW
- lipopolysaccharide biosynthetic process Source: UniProtKB-KW
- protein O-linked glycosylation Source: InterPro
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis |
Enzyme and pathway databases
BioCyci | PPRO220664:G1G4K-4589-MONOMER. |
UniPathwayi | UPA00037. |
Protein family/group databases
CAZyi | GT83. Glycosyltransferase Family 83. |
Names & Taxonomyi
Protein namesi | Recommended name: Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2UniRule annotation (EC:2.4.2.43UniRule annotation)Alternative name(s): 4-amino-4-deoxy-L-arabinose lipid A transferase 2UniRule annotation Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferaseUniRule annotation Undecaprenyl phosphate-alpha-L-Ara4N transferase 2UniRule annotation |
Gene namesi | Name:arnT2UniRule annotation Ordered Locus Names:PFL_4461 |
Organismi | Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) |
Taxonomic identifieri | 220664 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 42 – 62 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 113 – 135 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 145 – 165 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 166 – 186 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 209 – 229 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 241 – 261 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 290 – 310 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 321 – 341 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 345 – 365 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 380 – 400 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 409 – 429 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 440 – 460 | HelicalUniRule annotationAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000380020 | 1 – 583 | Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2Add BLAST | 583 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycosyltransferase 83 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105SA9. Bacteria. COG1807. LUCA. |
HOGENOMi | HOG000273002. |
KOi | K07264. |
OMAi | NTWGELE. |
OrthoDBi | POG091H00H0. |
Family and domain databases
HAMAPi | MF_01165. ArnT_transfer. 1 hit. |
InterProi | View protein in InterPro IPR022839. ArnT_tfrase. IPR003342. Glyco_trans_39/83. |
Pfami | View protein in Pfam PF02366. PMT. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q4K884-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSRIQMHRT SPPPAYGTSA PPSGFTLGAS TTSTLQRWAL PLLLVAFGLF
60 70 80 90 100
YLLPLTSHGL WIPDETRYAQ ISQEMLLSGD WVAPHFMGIR YFEKPIAGYW
110 120 130 140 150
LIAIGQAVFG DNLFGVRIAS ALSTGLSVLL AYLITRRMWN DPRKSFAAAL
160 170 180 190 200
LYMSFGLIAG QAGYSNLDPQ FTLWVNLSLV ALWFALDGRS TRERLLAWAG
210 220 230 240 250
LGVACGMGFM TKGFLAWLLP VLIALPYMIW QRRLGELVRY GLVAVLVAIG
260 270 280 290 300
ISLPWVLSIH AHEPDFWRFF FWHEHIRRFA ADNAQHTRPW WFYLPLLVAS
310 320 330 340 350
SLPWAALLPG TFMQAWKDKR QAPTGFLLLW FLLPLAFFSL SRGKLPTYIM
360 370 380 390 400
PCLLPLAVLM GSALIDRINA IQGRSIRINS LLNLLIGVAA MVALLYIQLT
410 420 430 440 450
RPVYGHNEML GLSLVFIMLM GWIIANLLPA ARPLQYWPAP ALGIWLLVAL
460 470 480 490 500
LPAGMPGFIV HNQMPDQFIK EHIEELRQTK TLLSNDLGAA SALAWRLQRP
510 520 530 540 550
EVTLYNTEGE LKYGLAYADS AQRKVSMAEV GQWVSEARKQ GSVGVVMRVK
560 570 580
DVVESEEVAL LPPGGKRYEE GNMLVLILPQ SQP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000076 Genomic DNA. Translation: AAY93712.1. |
RefSeqi | WP_011062724.1. NC_004129.6. |
Genome annotation databases
EnsemblBacteriai | AAY93712; AAY93712; PFL_4461. |
KEGGi | pfl:PFL_4461. |
PATRICi | fig|220664.5.peg.4566. |
Similar proteinsi
Entry informationi
Entry namei | ARNT2_PSEF5 | |
Accessioni | Q4K884Primary (citable) accession number: Q4K884 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 28, 2009 |
Last sequence update: | August 2, 2005 | |
Last modified: | March 28, 2018 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |