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Q4K884

- ARNT2_PSEF5

UniProt

Q4K884 - ARNT2_PSEF5

Protein

Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2

Gene

arnT2

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

    Catalytic activityi

    4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. mannosyltransferase activity Source: JCVI
    2. transferase activity, transferring pentosyl groups Source: InterPro

    GO - Biological processi

    1. lipid A biosynthetic process Source: JCVI
    2. lipopolysaccharide biosynthetic process Source: UniProtKB-KW
    3. mannosylation Source: GOC
    4. protein O-linked glycosylation Source: JCVI

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BioCyciPFLU220664:GIX8-4496-MONOMER.
    UniPathwayiUPA00037.

    Protein family/group databases

    CAZyiGT83. Glycosyltransferase Family 83.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2UniRule annotation (EC:2.4.2.43UniRule annotation)
    Alternative name(s):
    4-amino-4-deoxy-L-arabinose lipid A transferase 2UniRule annotation
    Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferaseUniRule annotation
    Undecaprenyl phosphate-alpha-L-Ara4N transferase 2UniRule annotation
    Gene namesi
    Name:arnT2UniRule annotation
    Ordered Locus Names:PFL_4461
    OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
    Taxonomic identifieri220664 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000008540: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 583583Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2PRO_0000380020Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi220664.PFL_4461.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221HelicalUniRule annotationAdd
    BLAST
    Transmembranei113 – 13523HelicalUniRule annotationAdd
    BLAST
    Transmembranei145 – 16521HelicalUniRule annotationAdd
    BLAST
    Transmembranei166 – 18621HelicalUniRule annotationAdd
    BLAST
    Transmembranei209 – 22921HelicalUniRule annotationAdd
    BLAST
    Transmembranei241 – 26121HelicalUniRule annotationAdd
    BLAST
    Transmembranei290 – 31021HelicalUniRule annotationAdd
    BLAST
    Transmembranei321 – 34121HelicalUniRule annotationAdd
    BLAST
    Transmembranei345 – 36521HelicalUniRule annotationAdd
    BLAST
    Transmembranei380 – 40021HelicalUniRule annotationAdd
    BLAST
    Transmembranei409 – 42921HelicalUniRule annotationAdd
    BLAST
    Transmembranei440 – 46021HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 83 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1807.
    HOGENOMiHOG000273002.
    KOiK07264.
    OMAiANIMESR.
    OrthoDBiEOG6NKQWN.

    Family and domain databases

    HAMAPiMF_01165. ArnT_transfer.
    InterProiIPR022839. ArnT_tfrase.
    IPR003342. Glyco_trans_39.
    [Graphical view]
    PfamiPF02366. PMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4K884-1 [UniParc]FASTAAdd to Basket

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    MTSRIQMHRT SPPPAYGTSA PPSGFTLGAS TTSTLQRWAL PLLLVAFGLF    50
    YLLPLTSHGL WIPDETRYAQ ISQEMLLSGD WVAPHFMGIR YFEKPIAGYW 100
    LIAIGQAVFG DNLFGVRIAS ALSTGLSVLL AYLITRRMWN DPRKSFAAAL 150
    LYMSFGLIAG QAGYSNLDPQ FTLWVNLSLV ALWFALDGRS TRERLLAWAG 200
    LGVACGMGFM TKGFLAWLLP VLIALPYMIW QRRLGELVRY GLVAVLVAIG 250
    ISLPWVLSIH AHEPDFWRFF FWHEHIRRFA ADNAQHTRPW WFYLPLLVAS 300
    SLPWAALLPG TFMQAWKDKR QAPTGFLLLW FLLPLAFFSL SRGKLPTYIM 350
    PCLLPLAVLM GSALIDRINA IQGRSIRINS LLNLLIGVAA MVALLYIQLT 400
    RPVYGHNEML GLSLVFIMLM GWIIANLLPA ARPLQYWPAP ALGIWLLVAL 450
    LPAGMPGFIV HNQMPDQFIK EHIEELRQTK TLLSNDLGAA SALAWRLQRP 500
    EVTLYNTEGE LKYGLAYADS AQRKVSMAEV GQWVSEARKQ GSVGVVMRVK 550
    DVVESEEVAL LPPGGKRYEE GNMLVLILPQ SQP 583
    Length:583
    Mass (Da):65,170
    Last modified:August 2, 2005 - v1
    Checksum:iF9231E122AABDCED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY93712.1.
    RefSeqiYP_261549.1. NC_004129.6.

    Genome annotation databases

    EnsemblBacteriaiAAY93712; AAY93712; PFL_4461.
    GeneIDi3478580.
    KEGGipfl:PFL_4461.
    PATRICi19878354. VBIPseFlu72549_4566.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY93712.1 .
    RefSeqi YP_261549.1. NC_004129.6.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220664.PFL_4461.

    Protein family/group databases

    CAZyi GT83. Glycosyltransferase Family 83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY93712 ; AAY93712 ; PFL_4461 .
    GeneIDi 3478580.
    KEGGi pfl:PFL_4461.
    PATRICi 19878354. VBIPseFlu72549_4566.

    Phylogenomic databases

    eggNOGi COG1807.
    HOGENOMi HOG000273002.
    KOi K07264.
    OMAi ANIMESR.
    OrthoDBi EOG6NKQWN.

    Enzyme and pathway databases

    UniPathwayi UPA00037 .
    BioCyci PFLU220664:GIX8-4496-MONOMER.

    Family and domain databases

    HAMAPi MF_01165. ArnT_transfer.
    InterProi IPR022839. ArnT_tfrase.
    IPR003342. Glyco_trans_39.
    [Graphical view ]
    Pfami PF02366. PMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf-5 / ATCC BAA-477.

    Entry informationi

    Entry nameiARNT2_PSEF5
    AccessioniPrimary (citable) accession number: Q4K884
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3