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UniProtKB - Q4K884 (ARNT2_PSEF5)

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Protein

Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2

Gene

arnT2

Organism
Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate.UniRule annotation

Pathwayi: 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis

This protein is involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis, which is part of Lipopolysaccharide metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis and in Lipopolysaccharide metabolism.

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00037.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2UniRule annotation (EC:2.4.2.43UniRule annotation)
Alternative name(s):
4-amino-4-deoxy-L-arabinose lipid A transferase 2UniRule annotation
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferaseUniRule annotation
Undecaprenyl phosphate-alpha-L-Ara4N transferase 2UniRule annotation
Gene namesi
Name:arnT2UniRule annotation
Ordered Locus Names:PFL_4461
OrganismiPseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas ›
Proteomesi
  • UP000008540 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalUniRule annotationAdd BLAST21
Transmembranei113 – 135HelicalUniRule annotationAdd BLAST23
Transmembranei145 – 165HelicalUniRule annotationAdd BLAST21
Transmembranei166 – 186HelicalUniRule annotationAdd BLAST21
Transmembranei209 – 229HelicalUniRule annotationAdd BLAST21
Transmembranei241 – 261HelicalUniRule annotationAdd BLAST21
Transmembranei290 – 310HelicalUniRule annotationAdd BLAST21
Transmembranei321 – 341HelicalUniRule annotationAdd BLAST21
Transmembranei345 – 365HelicalUniRule annotationAdd BLAST21
Transmembranei380 – 400HelicalUniRule annotationAdd BLAST21
Transmembranei409 – 429HelicalUniRule annotationAdd BLAST21
Transmembranei440 – 460HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003800201 – 583Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2Add BLAST583

Interactioni

Protein-protein interaction databases

STRINGi220664.PFL_4461.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 83 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105SA9. Bacteria.
COG1807. LUCA.
HOGENOMiHOG000273002.
KOiK07264.
OMAiISAPWAI.
OrthoDBiPOG091H00H0.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer. 1 hit.
InterProiView protein in InterPro
IPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39/83.
PfamiView protein in Pfam
PF02366. PMT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4K884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRIQMHRT SPPPAYGTSA PPSGFTLGAS TTSTLQRWAL PLLLVAFGLF 
        60         70         80         90        100
YLLPLTSHGL WIPDETRYAQ ISQEMLLSGD WVAPHFMGIR YFEKPIAGYW 
       110        120        130        140        150
LIAIGQAVFG DNLFGVRIAS ALSTGLSVLL AYLITRRMWN DPRKSFAAAL 
       160        170        180        190        200
LYMSFGLIAG QAGYSNLDPQ FTLWVNLSLV ALWFALDGRS TRERLLAWAG 
       210        220        230        240        250
LGVACGMGFM TKGFLAWLLP VLIALPYMIW QRRLGELVRY GLVAVLVAIG 
       260        270        280        290        300
ISLPWVLSIH AHEPDFWRFF FWHEHIRRFA ADNAQHTRPW WFYLPLLVAS 
       310        320        330        340        350
SLPWAALLPG TFMQAWKDKR QAPTGFLLLW FLLPLAFFSL SRGKLPTYIM 
       360        370        380        390        400
PCLLPLAVLM GSALIDRINA IQGRSIRINS LLNLLIGVAA MVALLYIQLT 
       410        420        430        440        450
RPVYGHNEML GLSLVFIMLM GWIIANLLPA ARPLQYWPAP ALGIWLLVAL 
       460        470        480        490        500
LPAGMPGFIV HNQMPDQFIK EHIEELRQTK TLLSNDLGAA SALAWRLQRP 
       510        520        530        540        550
EVTLYNTEGE LKYGLAYADS AQRKVSMAEV GQWVSEARKQ GSVGVVMRVK 
       560        570        580 
DVVESEEVAL LPPGGKRYEE GNMLVLILPQ SQP
Length:583
Mass (Da):65,170
Last modified:August 2, 2005 - v1
Checksum:iF9231E122AABDCED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY93712.1.
RefSeqiWP_011062724.1. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY93712; AAY93712; PFL_4461.
KEGGipfl:PFL_4461.
PATRICifig|220664.5.peg.4566.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY93712.1.
RefSeqiWP_011062724.1. NC_004129.6.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220664.PFL_4461.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY93712; AAY93712; PFL_4461.
KEGGipfl:PFL_4461.
PATRICifig|220664.5.peg.4566.

Phylogenomic databases

eggNOGiENOG4105SA9. Bacteria.
COG1807. LUCA.
HOGENOMiHOG000273002.
KOiK07264.
OMAiISAPWAI.
OrthoDBiPOG091H00H0.

Enzyme and pathway databases

UniPathwayiUPA00037.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer. 1 hit.
InterProiView protein in InterPro
IPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39/83.
PfamiView protein in Pfam
PF02366. PMT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARNT2_PSEF5
AccessioniPrimary (citable) accession number: Q4K884
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: August 2, 2005
Last modified: June 7, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.