ID   GCSP1_PSEF5             Reviewed;         951 AA.
AC   Q4K7Q8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Glycine dehydrogenase [decarboxylating] 1;
DE            EC=1.4.4.2;
DE   AltName: Full=Glycine decarboxylase 1;
DE   AltName: Full=Glycine cleavage system P-protein 1;
GN   Name=gcvP1; OrderedLocusNames=PFL_4641;
OS   Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=220664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15980861; DOI=10.1038/nbt1110;
RA   Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A.,
RA   Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J.,
RA   Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A.,
RA   Rosovitz M.J., Gwinn M.L., Zhou L., Schneider D.J., Cartinhour S.W.,
RA   Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A.,
RA   Pierson L.S. III, Thomashow L.S., Loper J.E.;
RT   "Complete genome sequence of the plant commensal Pseudomonas
RT   fluorescens Pf-5.";
RL   Nat. Biotechnol. 23:873-878(2005).
CC   -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC       glycine. The P protein binds the alpha-amino group of glycine
CC       through its pyridoxal phosphate cofactor; CO(2) is released and
CC       the remaining methylamine moiety is then transferred to the
CC       lipoamide cofactor of the H protein (By similarity).
CC   -!- CATALYTIC ACTIVITY: Glycine + H-protein-lipoyllysine = H-protein-
CC       S-aminomethyldihydrolipoyllysine + CO(2).
CC   -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC   -!- SUBUNIT: The glycine cleavage system is composed of four proteins:
CC       P, T, L and H (By similarity).
CC   -!- SIMILARITY: Belongs to the gcvP family.
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DR   EMBL; CP000076; AAY93888.1; -; Genomic_DNA.
DR   RefSeq; YP_261725.1; -.
DR   GeneID; 3478756; -.
DR   GenomeReviews; CP000076_GR; PFL_4641.
DR   KEGG; pfl:PFL_4641; -.
DR   NMPDR; fig|220664.3.peg.5278; -.
DR   HOGENOM; Q4K7Q8; -.
DR   OMA; Q4K7Q8; NRAESEM.
DR   BioCyc; PFLU220664:PFL_4641-MON; -.
DR   GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) act...; IEA:EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavag...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00711; -; 1.
DR   InterPro; IPR003437; GDC-P.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1.
DR   Gene3D; G3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1; 1.
DR   PANTHER; PTHR11773; GDC-P; 1.
DR   Pfam; PF02347; GDC-P; 1.
DR   TIGRFAMs; TIGR00461; gcvP; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Oxidoreductase; Pyridoxal phosphate.
FT   CHAIN         1    951       Glycine dehydrogenase [decarboxylating]
FT                                1.
FT                                /FTId=PRO_0000227116.
FT   MOD_RES     703    703       N6-(pyridoxal phosphate)lysine (By
FT                                similarity).
SQ   SEQUENCE   951 AA;  102473 MW;  BBF2ACC0CF69E95F CRC64;
     MTVNLSTANE FIARHIGPRQ GDEQAMLNSL GFDSLEALSA SVIPESIKGT SVLELGHGLS
     EAQALASIKA IAARNQLFKT YIGQGYYNCH TPSPILRNLL ENPAWYTAYT PYQPEISQGR
     LEALLNFQTL ISDLSGLPIA NASLLDEGTA AAEAMTFCKR LSKNKGSHAF FASQHCHPQT
     LDVLRTRAEP LGINVVVGDE RKLTDVSPFF GALLQYPASN GDLFDYRELT ERFHAANALV
     AVAADLLALT LLTPPGEFGA DVAIGSAQRF GVPLGFGGPH AAYFATRDAF KRDMPGRLVG
     VSVDRFGKPA LRLAMQTREQ HIRREKATSN ICTAQVLLAN IASMYAVYHG PKGLTQIAQR
     IHQLTAILAK GLVQLGLTVE QESFFDTLSL HTAGRTAALH DKARAQGINL RVIDAERLGL
     SLDETTTQAD VETLWSLLAD GKPAPDFAAL AAAVTSGIPA ALARQSAILS HPVFNRYHSE
     TELMRYLRKL ADKDLALDRT MIPLGSCTMK LNAASEMIPI TWAEFGALHP FAPAEQSAGY
     QQLTTELEAM LCAATGYDAV SLQPNAGSQG EYAGLLAIRA YHQSRGDERR DICLIPSSAH
     GTNPATANMA GMRVVVTACD ARGNVDIEDL RAKAIEHREH LAALMITYPS THGVFEEGIR
     EICGIIHDNG GQVYIDGANM NAMVGLCAPG KFGGDVSHLN LHKTFCIPHG GGGPGVGPIG
     VKSHLAPFLP GHAALENKKG AVCAAPFGSA SILPITWMYI SMMGGAGLKR ASQLAILNAN
     YISRRLEEHY PVLYTGSNGL VAHECILDLR PLKDSSGISV DDVAKRLIDF GFHAPTMSFP
     VAGTLMIEPT ESESKEELDR FCDAMIRIRE EIRAVENGAL DKDDNPLKNA PHTAAELVGE
     WSHPYSREQA VYPVASLVEG KYWPPVGRVD NVFGDRNLVC ACPSIESYQD A
//