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Q4K7Q8

- GCSP1_PSEF5

UniProt

Q4K7Q8 - GCSP1_PSEF5

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Protein

Glycine dehydrogenase (decarboxylating) 1

Gene

gcvP1

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-4674-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein 1UniRule annotation
Glycine decarboxylase 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) 1UniRule annotation
Gene namesi
Name:gcvP1UniRule annotation
Ordered Locus Names:PFL_4641
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008540: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 951951Glycine dehydrogenase (decarboxylating) 1PRO_0000227116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei703 – 7031N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi220664.PFL_4641.

Structurei

3D structure databases

ProteinModelPortaliQ4K7Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiERRDICL.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4K7Q8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVNLSTANE FIARHIGPRQ GDEQAMLNSL GFDSLEALSA SVIPESIKGT
60 70 80 90 100
SVLELGHGLS EAQALASIKA IAARNQLFKT YIGQGYYNCH TPSPILRNLL
110 120 130 140 150
ENPAWYTAYT PYQPEISQGR LEALLNFQTL ISDLSGLPIA NASLLDEGTA
160 170 180 190 200
AAEAMTFCKR LSKNKGSHAF FASQHCHPQT LDVLRTRAEP LGINVVVGDE
210 220 230 240 250
RKLTDVSPFF GALLQYPASN GDLFDYRELT ERFHAANALV AVAADLLALT
260 270 280 290 300
LLTPPGEFGA DVAIGSAQRF GVPLGFGGPH AAYFATRDAF KRDMPGRLVG
310 320 330 340 350
VSVDRFGKPA LRLAMQTREQ HIRREKATSN ICTAQVLLAN IASMYAVYHG
360 370 380 390 400
PKGLTQIAQR IHQLTAILAK GLVQLGLTVE QESFFDTLSL HTAGRTAALH
410 420 430 440 450
DKARAQGINL RVIDAERLGL SLDETTTQAD VETLWSLLAD GKPAPDFAAL
460 470 480 490 500
AAAVTSGIPA ALARQSAILS HPVFNRYHSE TELMRYLRKL ADKDLALDRT
510 520 530 540 550
MIPLGSCTMK LNAASEMIPI TWAEFGALHP FAPAEQSAGY QQLTTELEAM
560 570 580 590 600
LCAATGYDAV SLQPNAGSQG EYAGLLAIRA YHQSRGDERR DICLIPSSAH
610 620 630 640 650
GTNPATANMA GMRVVVTACD ARGNVDIEDL RAKAIEHREH LAALMITYPS
660 670 680 690 700
THGVFEEGIR EICGIIHDNG GQVYIDGANM NAMVGLCAPG KFGGDVSHLN
710 720 730 740 750
LHKTFCIPHG GGGPGVGPIG VKSHLAPFLP GHAALENKKG AVCAAPFGSA
760 770 780 790 800
SILPITWMYI SMMGGAGLKR ASQLAILNAN YISRRLEEHY PVLYTGSNGL
810 820 830 840 850
VAHECILDLR PLKDSSGISV DDVAKRLIDF GFHAPTMSFP VAGTLMIEPT
860 870 880 890 900
ESESKEELDR FCDAMIRIRE EIRAVENGAL DKDDNPLKNA PHTAAELVGE
910 920 930 940 950
WSHPYSREQA VYPVASLVEG KYWPPVGRVD NVFGDRNLVC ACPSIESYQD

A
Length:951
Mass (Da):102,473
Last modified:August 2, 2005 - v1
Checksum:iBBF2ACC0CF69E95F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY93888.1.
RefSeqiYP_261725.1. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY93888; AAY93888; PFL_4641.
GeneIDi3478756.
KEGGipfl:PFL_4641.
PATRICi19878724. VBIPseFlu72549_4747.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY93888.1 .
RefSeqi YP_261725.1. NC_004129.6.

3D structure databases

ProteinModelPortali Q4K7Q8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220664.PFL_4641.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY93888 ; AAY93888 ; PFL_4641 .
GeneIDi 3478756.
KEGGi pfl:PFL_4641.
PATRICi 19878724. VBIPseFlu72549_4747.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi ERRDICL.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PFLU220664:GIX8-4674-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiGCSP1_PSEF5
AccessioniPrimary (citable) accession number: Q4K7Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: August 2, 2005
Last modified: November 26, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3