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Q4K7Q8

- GCSP1_PSEF5

UniProt

Q4K7Q8 - GCSP1_PSEF5

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Protein
Glycine dehydrogenase (decarboxylating) 1
Gene
gcvP1, PFL_4641
Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-4674-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein 1
Glycine decarboxylase 1
Glycine dehydrogenase (aminomethyl-transferring) 1
Gene namesi
Name:gcvP1
Ordered Locus Names:PFL_4641
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008540: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 951951Glycine dehydrogenase (decarboxylating) 1UniRule annotation
PRO_0000227116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei703 – 7031N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi220664.PFL_4641.

Structurei

3D structure databases

ProteinModelPortaliQ4K7Q8.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiERRDICL.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4K7Q8-1 [UniParc]FASTAAdd to Basket

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MTVNLSTANE FIARHIGPRQ GDEQAMLNSL GFDSLEALSA SVIPESIKGT    50
SVLELGHGLS EAQALASIKA IAARNQLFKT YIGQGYYNCH TPSPILRNLL 100
ENPAWYTAYT PYQPEISQGR LEALLNFQTL ISDLSGLPIA NASLLDEGTA 150
AAEAMTFCKR LSKNKGSHAF FASQHCHPQT LDVLRTRAEP LGINVVVGDE 200
RKLTDVSPFF GALLQYPASN GDLFDYRELT ERFHAANALV AVAADLLALT 250
LLTPPGEFGA DVAIGSAQRF GVPLGFGGPH AAYFATRDAF KRDMPGRLVG 300
VSVDRFGKPA LRLAMQTREQ HIRREKATSN ICTAQVLLAN IASMYAVYHG 350
PKGLTQIAQR IHQLTAILAK GLVQLGLTVE QESFFDTLSL HTAGRTAALH 400
DKARAQGINL RVIDAERLGL SLDETTTQAD VETLWSLLAD GKPAPDFAAL 450
AAAVTSGIPA ALARQSAILS HPVFNRYHSE TELMRYLRKL ADKDLALDRT 500
MIPLGSCTMK LNAASEMIPI TWAEFGALHP FAPAEQSAGY QQLTTELEAM 550
LCAATGYDAV SLQPNAGSQG EYAGLLAIRA YHQSRGDERR DICLIPSSAH 600
GTNPATANMA GMRVVVTACD ARGNVDIEDL RAKAIEHREH LAALMITYPS 650
THGVFEEGIR EICGIIHDNG GQVYIDGANM NAMVGLCAPG KFGGDVSHLN 700
LHKTFCIPHG GGGPGVGPIG VKSHLAPFLP GHAALENKKG AVCAAPFGSA 750
SILPITWMYI SMMGGAGLKR ASQLAILNAN YISRRLEEHY PVLYTGSNGL 800
VAHECILDLR PLKDSSGISV DDVAKRLIDF GFHAPTMSFP VAGTLMIEPT 850
ESESKEELDR FCDAMIRIRE EIRAVENGAL DKDDNPLKNA PHTAAELVGE 900
WSHPYSREQA VYPVASLVEG KYWPPVGRVD NVFGDRNLVC ACPSIESYQD 950
A 951
Length:951
Mass (Da):102,473
Last modified:August 2, 2005 - v1
Checksum:iBBF2ACC0CF69E95F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY93888.1.
RefSeqiYP_261725.1. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY93888; AAY93888; PFL_4641.
GeneIDi3478756.
KEGGipfl:PFL_4641.
PATRICi19878724. VBIPseFlu72549_4747.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY93888.1 .
RefSeqi YP_261725.1. NC_004129.6.

3D structure databases

ProteinModelPortali Q4K7Q8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220664.PFL_4641.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY93888 ; AAY93888 ; PFL_4641 .
GeneIDi 3478756.
KEGGi pfl:PFL_4641.
PATRICi 19878724. VBIPseFlu72549_4747.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi ERRDICL.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PFLU220664:GIX8-4674-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiGCSP1_PSEF5
AccessioniPrimary (citable) accession number: Q4K7Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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