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Q4K7Q8

- GCSP1_PSEF5

UniProt

Q4K7Q8 - GCSP1_PSEF5

Protein

Glycine dehydrogenase (decarboxylating) 1

Gene

gcvP1

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPFLU220664:GIX8-4674-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating) 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein 1UniRule annotation
    Glycine decarboxylase 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) 1UniRule annotation
    Gene namesi
    Name:gcvP1UniRule annotation
    Ordered Locus Names:PFL_4641
    OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
    Taxonomic identifieri220664 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000008540: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 951951Glycine dehydrogenase (decarboxylating) 1PRO_0000227116Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei703 – 7031N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi220664.PFL_4641.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4K7Q8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiERRDICL.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4K7Q8-1 [UniParc]FASTAAdd to Basket

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    MTVNLSTANE FIARHIGPRQ GDEQAMLNSL GFDSLEALSA SVIPESIKGT    50
    SVLELGHGLS EAQALASIKA IAARNQLFKT YIGQGYYNCH TPSPILRNLL 100
    ENPAWYTAYT PYQPEISQGR LEALLNFQTL ISDLSGLPIA NASLLDEGTA 150
    AAEAMTFCKR LSKNKGSHAF FASQHCHPQT LDVLRTRAEP LGINVVVGDE 200
    RKLTDVSPFF GALLQYPASN GDLFDYRELT ERFHAANALV AVAADLLALT 250
    LLTPPGEFGA DVAIGSAQRF GVPLGFGGPH AAYFATRDAF KRDMPGRLVG 300
    VSVDRFGKPA LRLAMQTREQ HIRREKATSN ICTAQVLLAN IASMYAVYHG 350
    PKGLTQIAQR IHQLTAILAK GLVQLGLTVE QESFFDTLSL HTAGRTAALH 400
    DKARAQGINL RVIDAERLGL SLDETTTQAD VETLWSLLAD GKPAPDFAAL 450
    AAAVTSGIPA ALARQSAILS HPVFNRYHSE TELMRYLRKL ADKDLALDRT 500
    MIPLGSCTMK LNAASEMIPI TWAEFGALHP FAPAEQSAGY QQLTTELEAM 550
    LCAATGYDAV SLQPNAGSQG EYAGLLAIRA YHQSRGDERR DICLIPSSAH 600
    GTNPATANMA GMRVVVTACD ARGNVDIEDL RAKAIEHREH LAALMITYPS 650
    THGVFEEGIR EICGIIHDNG GQVYIDGANM NAMVGLCAPG KFGGDVSHLN 700
    LHKTFCIPHG GGGPGVGPIG VKSHLAPFLP GHAALENKKG AVCAAPFGSA 750
    SILPITWMYI SMMGGAGLKR ASQLAILNAN YISRRLEEHY PVLYTGSNGL 800
    VAHECILDLR PLKDSSGISV DDVAKRLIDF GFHAPTMSFP VAGTLMIEPT 850
    ESESKEELDR FCDAMIRIRE EIRAVENGAL DKDDNPLKNA PHTAAELVGE 900
    WSHPYSREQA VYPVASLVEG KYWPPVGRVD NVFGDRNLVC ACPSIESYQD 950
    A 951
    Length:951
    Mass (Da):102,473
    Last modified:August 2, 2005 - v1
    Checksum:iBBF2ACC0CF69E95F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY93888.1.
    RefSeqiYP_261725.1. NC_004129.6.

    Genome annotation databases

    EnsemblBacteriaiAAY93888; AAY93888; PFL_4641.
    GeneIDi3478756.
    KEGGipfl:PFL_4641.
    PATRICi19878724. VBIPseFlu72549_4747.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY93888.1 .
    RefSeqi YP_261725.1. NC_004129.6.

    3D structure databases

    ProteinModelPortali Q4K7Q8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220664.PFL_4641.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY93888 ; AAY93888 ; PFL_4641 .
    GeneIDi 3478756.
    KEGGi pfl:PFL_4641.
    PATRICi 19878724. VBIPseFlu72549_4747.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi ERRDICL.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PFLU220664:GIX8-4674-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf-5 / ATCC BAA-477.

    Entry informationi

    Entry nameiGCSP1_PSEF5
    AccessioniPrimary (citable) accession number: Q4K7Q8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3