Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycine dehydrogenase (decarboxylating) 1

Gene

gcvP1

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-4674-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein 1UniRule annotation
Glycine decarboxylase 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) 1UniRule annotation
Gene namesi
Name:gcvP1UniRule annotation
Ordered Locus Names:PFL_4641
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008540 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 951951Glycine dehydrogenase (decarboxylating) 1PRO_0000227116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei703 – 7031N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi220664.PFL_4641.

Structurei

3D structure databases

ProteinModelPortaliQ4K7Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4K7Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVNLSTANE FIARHIGPRQ GDEQAMLNSL GFDSLEALSA SVIPESIKGT
60 70 80 90 100
SVLELGHGLS EAQALASIKA IAARNQLFKT YIGQGYYNCH TPSPILRNLL
110 120 130 140 150
ENPAWYTAYT PYQPEISQGR LEALLNFQTL ISDLSGLPIA NASLLDEGTA
160 170 180 190 200
AAEAMTFCKR LSKNKGSHAF FASQHCHPQT LDVLRTRAEP LGINVVVGDE
210 220 230 240 250
RKLTDVSPFF GALLQYPASN GDLFDYRELT ERFHAANALV AVAADLLALT
260 270 280 290 300
LLTPPGEFGA DVAIGSAQRF GVPLGFGGPH AAYFATRDAF KRDMPGRLVG
310 320 330 340 350
VSVDRFGKPA LRLAMQTREQ HIRREKATSN ICTAQVLLAN IASMYAVYHG
360 370 380 390 400
PKGLTQIAQR IHQLTAILAK GLVQLGLTVE QESFFDTLSL HTAGRTAALH
410 420 430 440 450
DKARAQGINL RVIDAERLGL SLDETTTQAD VETLWSLLAD GKPAPDFAAL
460 470 480 490 500
AAAVTSGIPA ALARQSAILS HPVFNRYHSE TELMRYLRKL ADKDLALDRT
510 520 530 540 550
MIPLGSCTMK LNAASEMIPI TWAEFGALHP FAPAEQSAGY QQLTTELEAM
560 570 580 590 600
LCAATGYDAV SLQPNAGSQG EYAGLLAIRA YHQSRGDERR DICLIPSSAH
610 620 630 640 650
GTNPATANMA GMRVVVTACD ARGNVDIEDL RAKAIEHREH LAALMITYPS
660 670 680 690 700
THGVFEEGIR EICGIIHDNG GQVYIDGANM NAMVGLCAPG KFGGDVSHLN
710 720 730 740 750
LHKTFCIPHG GGGPGVGPIG VKSHLAPFLP GHAALENKKG AVCAAPFGSA
760 770 780 790 800
SILPITWMYI SMMGGAGLKR ASQLAILNAN YISRRLEEHY PVLYTGSNGL
810 820 830 840 850
VAHECILDLR PLKDSSGISV DDVAKRLIDF GFHAPTMSFP VAGTLMIEPT
860 870 880 890 900
ESESKEELDR FCDAMIRIRE EIRAVENGAL DKDDNPLKNA PHTAAELVGE
910 920 930 940 950
WSHPYSREQA VYPVASLVEG KYWPPVGRVD NVFGDRNLVC ACPSIESYQD

A
Length:951
Mass (Da):102,473
Last modified:August 2, 2005 - v1
Checksum:iBBF2ACC0CF69E95F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY93888.1.
RefSeqiWP_011062895.1. NC_004129.6.
YP_261725.1. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY93888; AAY93888; PFL_4641.
GeneIDi3478756.
KEGGipfl:PFL_4641.
PATRICi19878724. VBIPseFlu72549_4747.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY93888.1.
RefSeqiWP_011062895.1. NC_004129.6.
YP_261725.1. NC_004129.6.

3D structure databases

ProteinModelPortaliQ4K7Q8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220664.PFL_4641.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY93888; AAY93888; PFL_4641.
GeneIDi3478756.
KEGGipfl:PFL_4641.
PATRICi19878724. VBIPseFlu72549_4747.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-4674-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiGCSP1_PSEF5
AccessioniPrimary (citable) accession number: Q4K7Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: August 2, 2005
Last modified: May 27, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.