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Q4K7Q8 (GCSP1_PSEF5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating) 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein 1
Glycine decarboxylase 1
Glycine dehydrogenase (aminomethyl-transferring) 1
Gene names
Name:gcvP1
Ordered Locus Names:PFL_4641
OrganismPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP]
Taxonomic identifier220664 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length951 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 951951Glycine dehydrogenase (decarboxylating) 1 HAMAP-Rule MF_00711
PRO_0000227116

Amino acid modifications

Modified residue7031N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4K7Q8 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: BBF2ACC0CF69E95F

FASTA951102,473
        10         20         30         40         50         60 
MTVNLSTANE FIARHIGPRQ GDEQAMLNSL GFDSLEALSA SVIPESIKGT SVLELGHGLS 

        70         80         90        100        110        120 
EAQALASIKA IAARNQLFKT YIGQGYYNCH TPSPILRNLL ENPAWYTAYT PYQPEISQGR 

       130        140        150        160        170        180 
LEALLNFQTL ISDLSGLPIA NASLLDEGTA AAEAMTFCKR LSKNKGSHAF FASQHCHPQT 

       190        200        210        220        230        240 
LDVLRTRAEP LGINVVVGDE RKLTDVSPFF GALLQYPASN GDLFDYRELT ERFHAANALV 

       250        260        270        280        290        300 
AVAADLLALT LLTPPGEFGA DVAIGSAQRF GVPLGFGGPH AAYFATRDAF KRDMPGRLVG 

       310        320        330        340        350        360 
VSVDRFGKPA LRLAMQTREQ HIRREKATSN ICTAQVLLAN IASMYAVYHG PKGLTQIAQR 

       370        380        390        400        410        420 
IHQLTAILAK GLVQLGLTVE QESFFDTLSL HTAGRTAALH DKARAQGINL RVIDAERLGL 

       430        440        450        460        470        480 
SLDETTTQAD VETLWSLLAD GKPAPDFAAL AAAVTSGIPA ALARQSAILS HPVFNRYHSE 

       490        500        510        520        530        540 
TELMRYLRKL ADKDLALDRT MIPLGSCTMK LNAASEMIPI TWAEFGALHP FAPAEQSAGY 

       550        560        570        580        590        600 
QQLTTELEAM LCAATGYDAV SLQPNAGSQG EYAGLLAIRA YHQSRGDERR DICLIPSSAH 

       610        620        630        640        650        660 
GTNPATANMA GMRVVVTACD ARGNVDIEDL RAKAIEHREH LAALMITYPS THGVFEEGIR 

       670        680        690        700        710        720 
EICGIIHDNG GQVYIDGANM NAMVGLCAPG KFGGDVSHLN LHKTFCIPHG GGGPGVGPIG 

       730        740        750        760        770        780 
VKSHLAPFLP GHAALENKKG AVCAAPFGSA SILPITWMYI SMMGGAGLKR ASQLAILNAN 

       790        800        810        820        830        840 
YISRRLEEHY PVLYTGSNGL VAHECILDLR PLKDSSGISV DDVAKRLIDF GFHAPTMSFP 

       850        860        870        880        890        900 
VAGTLMIEPT ESESKEELDR FCDAMIRIRE EIRAVENGAL DKDDNPLKNA PHTAAELVGE 

       910        920        930        940        950 
WSHPYSREQA VYPVASLVEG KYWPPVGRVD NVFGDRNLVC ACPSIESYQD A 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000076 Genomic DNA. Translation: AAY93888.1.
RefSeqYP_261725.1. NC_004129.6.

3D structure databases

ProteinModelPortalQ4K7Q8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220664.PFL_4641.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY93888; AAY93888; PFL_4641.
GeneID3478756.
KEGGpfl:PFL_4641.
PATRIC19878724. VBIPseFlu72549_4747.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAERRDICL.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycPFLU220664:GIX8-4674-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP1_PSEF5
AccessionPrimary (citable) accession number: Q4K7Q8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families