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Q4K5F9

- PROA_PSEF5

UniProt

Q4K5F9 - PROA_PSEF5

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Protein

Gamma-glutamyl phosphate reductase

Gene
proA, PFL_5456
Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity.

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: InterPro

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-5493-MONOMER.
UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductase (EC:1.2.1.41)
Short name:
GPR
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name:
GSA dehydrogenase
Gene namesi
Name:proA
Ordered Locus Names:PFL_5456
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008540: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Gamma-glutamyl phosphate reductaseUniRule annotationPRO_0000230014Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220664.PFL_5456.

Structurei

3D structure databases

ProteinModelPortaliQ4K5F9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0014.
HOGENOMiHOG000246356.
KOiK00147.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 2 hits.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4K5F9-1 [UniParc]FASTAAdd to Basket

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MTESVLDYMT RLGRAARQAS RVIARATTAQ KNRALLAAAD ALDAARPELT    50
AANEQDLANG RANGLEPALL DRLALTPARI DEMIEGLRQV AKLPDPIGEI 100
RDMRYLPSGI QVGKMRVPLG VIGIIYESRP NVTIDAASLC LKSGNATILR 150
GGSEAIHSNR AIATCIQQGL AAADLPPHVV QVVETTDRAA VGALITMPEF 200
VDVIVPRGGK SLIERVSRDA KVPVIKHLDG VCHVYIDVAA DLDKAIRIAD 250
NAKTQRYAPC NTMETLLVHS AIAERVLPPL AAIYRDKGVE LRGCAQTRAL 300
LGAGVLEATE EDWRTEYTAP ILSIRVLDNL EQAIEHINTY GSHHTDSIVT 350
ENFSDARRFL NEVDSSSVMV NASTRFADGF EYGLGAEIGI STDKLHARGP 400
VGLEGLTSEK YVVFGDGHVR T 421
Length:421
Mass (Da):45,393
Last modified:April 4, 2006 - v2
Checksum:i96451F6DACB70E19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY94666.2.
RefSeqiYP_262524.2. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY94666; AAY94666; PFL_5456.
GeneIDi3479848.
KEGGipfl:PFL_5456.
PATRICi19880399. VBIPseFlu72549_5570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY94666.2 .
RefSeqi YP_262524.2. NC_004129.6.

3D structure databases

ProteinModelPortali Q4K5F9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220664.PFL_5456.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY94666 ; AAY94666 ; PFL_5456 .
GeneIDi 3479848.
KEGGi pfl:PFL_5456.
PATRICi 19880399. VBIPseFlu72549_5570.

Phylogenomic databases

eggNOGi COG0014.
HOGENOMi HOG000246356.
KOi K00147.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00360 .
BioCyci PFLU220664:GIX8-5493-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPi MF_00412. ProA.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR012134. Glu-5-SA_DH.
[Graphical view ]
Pfami PF00171. Aldedh. 2 hits.
[Graphical view ]
PIRSFi PIRSF000151. GPR. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00407. proA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiPROA_PSEF5
AccessioniPrimary (citable) accession number: Q4K5F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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