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Q4K5F9

- PROA_PSEF5

UniProt

Q4K5F9 - PROA_PSEF5

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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: InterPro

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-5493-MONOMER.
UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:PFL_5456
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008540: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Gamma-glutamyl phosphate reductasePRO_0000230014Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220664.PFL_5456.

Structurei

3D structure databases

ProteinModelPortaliQ4K5F9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0014.
HOGENOMiHOG000246356.
KOiK00147.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 2 hits.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4K5F9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTESVLDYMT RLGRAARQAS RVIARATTAQ KNRALLAAAD ALDAARPELT
60 70 80 90 100
AANEQDLANG RANGLEPALL DRLALTPARI DEMIEGLRQV AKLPDPIGEI
110 120 130 140 150
RDMRYLPSGI QVGKMRVPLG VIGIIYESRP NVTIDAASLC LKSGNATILR
160 170 180 190 200
GGSEAIHSNR AIATCIQQGL AAADLPPHVV QVVETTDRAA VGALITMPEF
210 220 230 240 250
VDVIVPRGGK SLIERVSRDA KVPVIKHLDG VCHVYIDVAA DLDKAIRIAD
260 270 280 290 300
NAKTQRYAPC NTMETLLVHS AIAERVLPPL AAIYRDKGVE LRGCAQTRAL
310 320 330 340 350
LGAGVLEATE EDWRTEYTAP ILSIRVLDNL EQAIEHINTY GSHHTDSIVT
360 370 380 390 400
ENFSDARRFL NEVDSSSVMV NASTRFADGF EYGLGAEIGI STDKLHARGP
410 420
VGLEGLTSEK YVVFGDGHVR T
Length:421
Mass (Da):45,393
Last modified:April 4, 2006 - v2
Checksum:i96451F6DACB70E19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY94666.2.
RefSeqiYP_262524.2. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY94666; AAY94666; PFL_5456.
GeneIDi3479848.
KEGGipfl:PFL_5456.
PATRICi19880399. VBIPseFlu72549_5570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY94666.2 .
RefSeqi YP_262524.2. NC_004129.6.

3D structure databases

ProteinModelPortali Q4K5F9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220664.PFL_5456.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY94666 ; AAY94666 ; PFL_5456 .
GeneIDi 3479848.
KEGGi pfl:PFL_5456.
PATRICi 19880399. VBIPseFlu72549_5570.

Phylogenomic databases

eggNOGi COG0014.
HOGENOMi HOG000246356.
KOi K00147.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00360 .
BioCyci PFLU220664:GIX8-5493-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPi MF_00412. ProA.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR012134. Glu-5-SA_DH.
[Graphical view ]
Pfami PF00171. Aldedh. 2 hits.
[Graphical view ]
PIRSFi PIRSF000151. GPR. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00407. proA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiPROA_PSEF5
AccessioniPrimary (citable) accession number: Q4K5F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: October 29, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3