ID   APAH_PSEF5              Reviewed;         289 AA.
AC   Q4K4X3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase, symmetrical;
DE            EC=3.6.1.41;
DE   AltName: Full=Diadenosine tetraphosphatase;
DE   AltName: Full=Ap4A hydrolase;
DE   AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase;
GN   Name=apaH; OrderedLocusNames=PFL_5651;
OS   Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=220664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15980861; DOI=10.1038/nbt1110;
RA   Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A.,
RA   Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J.,
RA   Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A.,
RA   Rosovitz M.J., Gwinn M.L., Zhou L., Schneider D.J., Cartinhour S.W.,
RA   Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A.,
RA   Pierson L.S. III, Thomashow L.S., Loper J.E.;
RT   "Complete genome sequence of the plant commensal Pseudomonas
RT   fluorescens Pf-5.";
RL   Nat. Biotechnol. 23:873-878(2005).
CC   -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to
CC       yield ADP (By similarity).
CC   -!- CATALYTIC ACTIVITY: P(1),P(4)-bis(5'-adenosyl) tetraphosphate +
CC       H(2)O = 2 ADP.
CC   -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
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DR   EMBL; CP000076; AAY94844.1; -; Genomic_DNA.
DR   RefSeq; YP_262710.1; -.
DR   GeneID; 3480026; -.
DR   GenomeReviews; CP000076_GR; PFL_5651.
DR   KEGG; pfl:PFL_5651; -.
DR   NMPDR; fig|220664.3.peg.1221; -.
DR   HOGENOM; Q4K4X3; -.
DR   OMA; Q4K4X3; LVFGHWA.
DR   BioCyc; PFLU220664:PFL_5651-MON; -.
DR   GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetr...; IEA:HAMAP.
DR   HAMAP; MF_00199; -; 1.
DR   InterPro; IPR004617; ApaH.
DR   InterPro; IPR004843; M-pesterase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR   TIGRFAMs; TIGR00668; apaH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    289       Bis(5'-nucleosyl)-tetraphosphatase,
FT                                symmetrical.
FT                                /FTId=PRO_1000012078.
SQ   SEQUENCE   289 AA;  32526 MW;  BB302E6FE829B4A8 CRC64;
     MATYAVGDLQ GCLEPLQCLL EQVAFDPARD RLWLVGDLVN RGPQSLETLR YLYSIRDSLV
     CVLGNHDLHL LAVWRNVERL KKSDTLREIL EAPDCEELLQ WLRQQKLMHY DEARNIAMVH
     AGIAPQWSLK KAQKCAAEVE EALRDDNLFD PFLDGMYGND PAKWDSDLKG VTRLRVITNY
     FTRMRFCTSD GKLDLKSKEG LDTAPPGYAP WFSHKERKTR DLKIIFGHWA ALEGHCNEPG
     IFALDSGCVW GGAMTLLNVD SGVRLTCDCD AQGRTAALSP DPLPAPAKR
//