Q4K4X3 (APAH_PSEF5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase

Gene names

Name:	apaH
Ordered Locus Names:	PFL_5651

Organism

Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP]

Taxonomic identifier

220664 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP MF_00199
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_1000012078

Sequences

	Sequence		Length	Mass (Da)
	Q4K4X3 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: BB302E6FE829B4A8	FASTA	289	32,526
	10 20 30 40 50 60 MATYAVGDLQ GCLEPLQCLL EQVAFDPARD RLWLVGDLVN RGPQSLETLR YLYSIRDSLV 70 80 90 100 110 120 CVLGNHDLHL LAVWRNVERL KKSDTLREIL EAPDCEELLQ WLRQQKLMHY DEARNIAMVH 130 140 150 160 170 180 AGIAPQWSLK KAQKCAAEVE EALRDDNLFD PFLDGMYGND PAKWDSDLKG VTRLRVITNY 190 200 210 220 230 240 FTRMRFCTSD GKLDLKSKEG LDTAPPGYAP WFSHKERKTR DLKIIFGHWA ALEGHCNEPG 250 260 270 280 IFALDSGCVW GGAMTLLNVD SGVRLTCDCD AQGRTAALSP DPLPAPAKR

References

[1]

"Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5." Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A., Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J., Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A., Rosovitz M.J., Gwinn M.L., Zhou L. , Schneider D.J., Cartinhour S.W., Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A., Pierson L.S. III, Thomashow L.S., Loper J.E. Nat. Biotechnol. 23:873-878(2005) [PubMed: 15980861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pf-5 / ATCC BAA-477.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000076 Genomic DNA. Translation: AAY94844.1.
RefSeq	YP_262710.1. NC_004129.6.
3D structure databases
ProteinModelPortal	Q4K4X3.
SMR	Q4K4X3. Positions 2-265.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4K4X3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3480026.
GenomeReviews	Gene locus PFL_5651 in contig CP000076_GR.
KEGG	pfl:PFL_5651.
NMPDR	fig|220664.3.peg.1221.
PATRIC	19880803. VBIPseFlu72549_5763.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0639.
HOGENOM	HBG724457.
OMA	LVFGHWA.
PhylomeDB	Q4K4X3.
ProtClustDB	PRK00166.
Enzyme and pathway databases
BioCyc	PFLU220664:PFL_5651-MONOMER.
Family and domain databases
HAMAP	MF_00199. ApaH. [Tree]
InterPro	IPR004617. ApaH. IPR004843. Metallo_PEstase_dom. [Graphical view]
KO	K01525.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. ApaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_PSEF5

Accession

Primary (citable) accession number: Q4K4X3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program