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Q4K4K8 (BETB_PSEF5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:PFL_5767
OrganismPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP]
Taxonomic identifier220664 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processbetaine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Betaine aldehyde dehydrogenase HAMAP MF_00804
PRO_0000056550

Regions

Nucleotide binding229 – 2346NAD By similarity

Sites

Active site2521 By similarity
Active site2861 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4K4K8 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: A9CABF16B93B1D65

FASTA49053,156
        10         20         30         40         50         60 
MARFELQKLY IDGGYTDAGS DATFDAINPA NGEVLAQVQR ATKEDVERAV VSAEKGQKIW 

        70         80         90        100        110        120 
AAMTAMERSR ILRRAVEILR ERNDELAALE TLDTGKAFSE TKYVDIVTGA DVLEYYAGLV 

       130        140        150        160        170        180 
PAIEGEQIPL RTTSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 

       190        200        210        220        230        240 
TSLTTLKLAE IYTEAGLPDG VFNVLTGSGR EVGTWLTEHP RIEKVSFTGG TDTGKKVMAS 

       250        260        270        280        290        300 
ASSSSLKDVT MELGGKSPLI IFDDADLDRA ADTAMMANFY SSGQVCTNGT RVFVPSHLKA 

       310        320        330        340        350        360 
AFEAKIAERV ARIRIGNPED ENTNFGPLVS FPHMESVLGY IAKGKEEGAR VLCGGERLTD 

       370        380        390        400        410        420 
GEFAKGAFVA PTVFTDCTDD MTIVREEIFG PVMAILTYET EEEVIRRAND TDFGLAAGLV 

       430        440        450        460        470        480 
TKDLNRAHRV IHQLEAGICW INAWGESDAK MPVGGYKQSG VGRENGISSL NNFTRIKSVQ 

       490 
VELGDYASVF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000076 Genomic DNA. Translation: AAY94957.1.
RefSeqYP_262825.1. NC_004129.6.

3D structure databases

ProteinModelPortalQ4K4K8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4K4K8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3480139.
GenomeReviewsGene locus PFL_5767 in contig CP000076_GR.
KEGGpfl:PFL_5767.
NMPDRfig|220664.3.peg.14.
PATRIC19881039. VBIPseFlu72549_5880.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHBG752218.
OMAAHRTIHR.
PhylomeDBQ4K4K8.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycPFLU220664:PFL_5767-MONOMER.

Family and domain databases

HAMAPMF_00804. BADH.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00130.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_PSEF5
AccessionPrimary (citable) accession number: Q4K4K8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 2, 2005
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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