Reviewed, UniProtKB/Swiss-Prot Q4K4K8 (BETB_PSEF5)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	PFL_5767

Organism

Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP]

Taxonomic identifier

220664 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_0000056550
Regions
	Nucleotide binding	229 – 234	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4K4K8-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: A9CABF16B93B1D65	FASTA	490	53,156
	10 20 30 40 50 60 MARFELQKLY IDGGYTDAGS DATFDAINPA NGEVLAQVQR ATKEDVERAV VSAEKGQKIW 70 80 90 100 110 120 AAMTAMERSR ILRRAVEILR ERNDELAALE TLDTGKAFSE TKYVDIVTGA DVLEYYAGLV 130 140 150 160 170 180 PAIEGEQIPL RTTSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 190 200 210 220 230 240 TSLTTLKLAE IYTEAGLPDG VFNVLTGSGR EVGTWLTEHP RIEKVSFTGG TDTGKKVMAS 250 260 270 280 290 300 ASSSSLKDVT MELGGKSPLI IFDDADLDRA ADTAMMANFY SSGQVCTNGT RVFVPSHLKA 310 320 330 340 350 360 AFEAKIAERV ARIRIGNPED ENTNFGPLVS FPHMESVLGY IAKGKEEGAR VLCGGERLTD 370 380 390 400 410 420 GEFAKGAFVA PTVFTDCTDD MTIVREEIFG PVMAILTYET EEEVIRRAND TDFGLAAGLV 430 440 450 460 470 480 TKDLNRAHRV IHQLEAGICW INAWGESDAK MPVGGYKQSG VGRENGISSL NNFTRIKSVQ 490 VELGDYASVF

References

[1]

"Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5." Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A., Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J., Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A., Rosovitz M.J., Gwinn M.L., Zhou L. , Schneider D.J., Cartinhour S.W., Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A., Pierson L.S. III, Thomashow L.S., Loper J.E. Nat. Biotechnol. 23:873-878(2005) [PubMed: 15980861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000076 Genomic DNA. Translation: AAY94957.1.
RefSeq	YP_262825.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3480139.
GenomeReviews	Gene locus PFL_5767 in contig CP000076_GR.
KEGG	pfl:PFL_5767.
NMPDR	fig|220664.3.peg.14.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4K4K8.
Enzyme and pathway databases
BioCyc	PFLU220664:PFL_5767-MON.
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR011264. Betaine_Ald_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_PSEF5

Accession

Primary (citable) accession number: Q4K4K8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	August 2, 2005
Last modified:	November 4, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)