ID   BETA_PSEF5              Reviewed;         567 AA.
AC   Q4K4K7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=Choline dehydrogenase;
DE            Short=CHD;
DE            Short=CDH;
DE            EC=1.1.99.1;
GN   Name=betA; OrderedLocusNames=PFL_5768;
OS   Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=220664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15980861; DOI=10.1038/nbt1110;
RA   Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A.,
RA   Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J.,
RA   Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A.,
RA   Rosovitz M.J., Gwinn M.L., Zhou L., Schneider D.J., Cartinhour S.W.,
RA   Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A.,
RA   Pierson L.S. III, Thomashow L.S., Loper J.E.;
RT   "Complete genome sequence of the plant commensal Pseudomonas
RT   fluorescens Pf-5.";
RL   Nat. Biotechnol. 23:873-878(2005).
CC   -!- FUNCTION: Can catalyze the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC       reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
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DR   EMBL; CP000076; AAY94958.1; -; Genomic_DNA.
DR   RefSeq; YP_262826.1; -.
DR   GeneID; 3480140; -.
DR   GenomeReviews; CP000076_GR; PFL_5768.
DR   KEGG; pfl:PFL_5768; -.
DR   NMPDR; fig|220664.3.peg.15; -.
DR   HOGENOM; Q4K4K7; -.
DR   OMA; Q4K4K7; GRRMECG.
DR   BioCyc; PFLU220664:PFL_5768-MON; -.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00750; -; 1.
DR   InterPro; IPR011533; Choline_dehydrogenase.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN         1    567       Choline dehydrogenase.
FT                                /FTId=PRO_0000258928.
FT   NP_BIND       6     35       FAD (Probable).
FT   ACT_SITE    475    475       By similarity.
SQ   SEQUENCE   567 AA;  62704 MW;  513BE86614467644 CRC64;
     MAQEYDYIIV GAGSAGNTLA TRLTEDEGVT VLLLEAGGPD YRFDFRTQMP AALAFPLQGR
     RYNWAYETDP EPHMNGRRME CGRGKGLGGS SLINGMCYIR GNAMDYDGWA KLPGLEDWTY
     LDCLPYFRKA ETRDIGPNDY HGGEGPVSVT TPKAGNNPLF HAMVEAGVQA GYPRTEDLNG
     YQQEGFGPMD RTVTPKGRRA STARGYLDTA KKRSTLTIVT HALTDKILFE GKRAVGVSYL
     QGSTEERVEA RARKEVIVSS GAIASPQLLQ RSGVGPRALL ESLDIPVVHD LPGVGENLQD
     HLELYLQYAC TQPVSLYPSL LWWNQPAIGA EWLFNGTGIG ASNQFEAGGF IRTREEFEWP
     NIQYHFLPVA INYNGSNGVK EHGFQAHMGS MRSPSRGRVQ LKSKDPRQHP SILFNYMATE
     QDWQEFRDGI RLTREIMQQP ALDPFRGREI SPGIEVQTDE QLDKFVREHA ETAFHPSCSC
     KMGTDDMAVV DGQGRVHGMQ GLRVVDASIM PIITTGNLNA PTIMMAEKIA DKIRGRQPLP
     RSTAAYYVAG EAPVRGKPMR DVTPAAQ
//