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Q4K4K7

- BETA_PSEF5

UniProt

Q4K4K7 - BETA_PSEF5

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei475 – 4751UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 3530FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-5808-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:PFL_5768
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008540: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Oxygen-dependent choline dehydrogenasePRO_0000258928Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220664.PFL_5768.

Structurei

3D structure databases

ProteinModelPortaliQ4K4K7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4K4K7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQEYDYIIV GAGSAGNTLA TRLTEDEGVT VLLLEAGGPD YRFDFRTQMP
60 70 80 90 100
AALAFPLQGR RYNWAYETDP EPHMNGRRME CGRGKGLGGS SLINGMCYIR
110 120 130 140 150
GNAMDYDGWA KLPGLEDWTY LDCLPYFRKA ETRDIGPNDY HGGEGPVSVT
160 170 180 190 200
TPKAGNNPLF HAMVEAGVQA GYPRTEDLNG YQQEGFGPMD RTVTPKGRRA
210 220 230 240 250
STARGYLDTA KKRSTLTIVT HALTDKILFE GKRAVGVSYL QGSTEERVEA
260 270 280 290 300
RARKEVIVSS GAIASPQLLQ RSGVGPRALL ESLDIPVVHD LPGVGENLQD
310 320 330 340 350
HLELYLQYAC TQPVSLYPSL LWWNQPAIGA EWLFNGTGIG ASNQFEAGGF
360 370 380 390 400
IRTREEFEWP NIQYHFLPVA INYNGSNGVK EHGFQAHMGS MRSPSRGRVQ
410 420 430 440 450
LKSKDPRQHP SILFNYMATE QDWQEFRDGI RLTREIMQQP ALDPFRGREI
460 470 480 490 500
SPGIEVQTDE QLDKFVREHA ETAFHPSCSC KMGTDDMAVV DGQGRVHGMQ
510 520 530 540 550
GLRVVDASIM PIITTGNLNA PTIMMAEKIA DKIRGRQPLP RSTAAYYVAG
560
EAPVRGKPMR DVTPAAQ
Length:567
Mass (Da):62,704
Last modified:August 2, 2005 - v1
Checksum:i513BE86614467644
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY94958.1.
RefSeqiYP_262826.1. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY94958; AAY94958; PFL_5768.
GeneIDi3480140.
KEGGipfl:PFL_5768.
PATRICi19881041. VBIPseFlu72549_5881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY94958.1 .
RefSeqi YP_262826.1. NC_004129.6.

3D structure databases

ProteinModelPortali Q4K4K7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220664.PFL_5768.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY94958 ; AAY94958 ; PFL_5768 .
GeneIDi 3480140.
KEGGi pfl:PFL_5768.
PATRICi 19881041. VBIPseFlu72549_5881.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci PFLU220664:GIX8-5808-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiBETA_PSEF5
AccessioniPrimary (citable) accession number: Q4K4K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 2, 2005
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3