Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycine dehydrogenase (decarboxylating) 2

Gene

gcvP2

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-6001-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein 2UniRule annotation
Glycine decarboxylase 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) 2UniRule annotation
Gene namesi
Name:gcvP2UniRule annotation
Ordered Locus Names:PFL_5959
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008540: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Glycine dehydrogenase (decarboxylating) 2PRO_0000227117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei707 – 7071N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ4K416.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi220664.PFL_5959.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMGPQLAD.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4K416-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQLLSLSQL REPNAFLNRH LGPDAEEQQA MLASLGLGSR AELIEQTVPP
60 70 80 90 100
GIRFNRALDL PPALDEAAAL ARLKGYAGQN QVWTSLIGMG YHATLTPTVI
110 120 130 140 150
LRNVLENPGW YTAYTPYQPE IAQGRLEALL NFQQMTIDLT GLDLANASLL
160 170 180 190 200
DEATAAAEAM ALAKRVSKSS SNLFFVDEHC HPQTVSVVRT RAEGFGFELV
210 220 230 240 250
VGGVDELSGH QVFGALLQYP DTHGEIRDLR PLIDQLHAQQ ALACVAADLL
260 270 280 290 300
SLLLLTPPGE LGADVVLGSS QRFGVPMGYG GPHAAFFACR DDYKRAMPGR
310 320 330 340 350
IIGVSKDARG QVALRMALQT REQHIRREKA NSNICTAQVL LANIAGFYAV
360 370 380 390 400
YHGPAGLKRI AQRVHRLTCI LAVGLERHGI ARVNRHFFDT LTLEVGGSQT
410 420 430 440 450
AIIESARAQQ INLRILGRGR LGLSLDETCD ESTVTRLFDV FLGADHGLDV
460 470 480 490 500
SNLDAEALES GIPDPLLRRT RYLTHPVFSA HHSETEMLRY LKQLENKDLA
510 520 530 540 550
LNQSMIPLGS CTMKLNASSE MIPITWPEFA NLHPFAPREQ AAGYGLLIAE
560 570 580 590 600
LERWLCAITG FDAICMQPNS GAQGEYAGLL AIRRYHESRR QGGRHVCLIP
610 620 630 640 650
ASAHGTNPAS AQMAGMQVVI VECDEAGNVD LEDLKAKAQA AGERLSCLMA
660 670 680 690 700
TYPSTHGVYE EGISQICEVI HSHGGQVYMD GANLNAQVGL ARPADIGADV
710 720 730 740 750
SHMNLHKTFC IPHGGGGPGM GPIGVRAHLA PFVANHPVVP IDGPLPENGA
760 770 780 790 800
VSAAPWGSAS ILPISWMYIA LMGPQLADAS EVAILAANYL AEQLSGAFPV
810 820 830 840 850
LYSGRNGRVA HECILDLRPL KAQTGISEED VAKRLMDYGF HAPTMSFPVP
860 870 880 890 900
GTLMVEPTES ESKAELDRFI EAMLSIRAEI AQVQEGNWPA EDNPLKGAPH
910 920 930 940 950
TLADITGVWE RSYSIEQAVL PTAHTRAHKY WPAVNRVDNV YGDRNLFCAC

VPLADYR
Length:957
Mass (Da):103,724
Last modified:March 21, 2012 - v2
Checksum:i9C80D645FCCA4F57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY95149.2.
RefSeqiYP_263017.2. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY95149; AAY95149; PFL_5959.
GeneIDi3480331.
KEGGipfl:PFL_5959.
PATRICi19881431. VBIPseFlu72549_6076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY95149.2.
RefSeqiYP_263017.2. NC_004129.6.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220664.PFL_5959.

Proteomic databases

PRIDEiQ4K416.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY95149; AAY95149; PFL_5959.
GeneIDi3480331.
KEGGipfl:PFL_5959.
PATRICi19881431. VBIPseFlu72549_6076.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMGPQLAD.

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-6001-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiGCSP2_PSEF5
AccessioniPrimary (citable) accession number: Q4K416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 21, 2012
Last modified: January 7, 2015
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.