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Q4K416

- GCSP2_PSEF5

UniProt

Q4K416 - GCSP2_PSEF5

Protein

Glycine dehydrogenase (decarboxylating) 2

Gene

gcvP2

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 2 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPFLU220664:GIX8-6001-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating) 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein 2UniRule annotation
    Glycine decarboxylase 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) 2UniRule annotation
    Gene namesi
    Name:gcvP2UniRule annotation
    Ordered Locus Names:PFL_5959
    OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
    Taxonomic identifieri220664 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000008540: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 957957Glycine dehydrogenase (decarboxylating) 2PRO_0000227117Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei707 – 7071N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiQ4K416.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi220664.PFL_5959.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4K416-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQLLSLSQL REPNAFLNRH LGPDAEEQQA MLASLGLGSR AELIEQTVPP    50
    GIRFNRALDL PPALDEAAAL ARLKGYAGQN QVWTSLIGMG YHATLTPTVI 100
    LRNVLENPGW YTAYTPYQPE IAQGRLEALL NFQQMTIDLT GLDLANASLL 150
    DEATAAAEAM ALAKRVSKSS SNLFFVDEHC HPQTVSVVRT RAEGFGFELV 200
    VGGVDELSGH QVFGALLQYP DTHGEIRDLR PLIDQLHAQQ ALACVAADLL 250
    SLLLLTPPGE LGADVVLGSS QRFGVPMGYG GPHAAFFACR DDYKRAMPGR 300
    IIGVSKDARG QVALRMALQT REQHIRREKA NSNICTAQVL LANIAGFYAV 350
    YHGPAGLKRI AQRVHRLTCI LAVGLERHGI ARVNRHFFDT LTLEVGGSQT 400
    AIIESARAQQ INLRILGRGR LGLSLDETCD ESTVTRLFDV FLGADHGLDV 450
    SNLDAEALES GIPDPLLRRT RYLTHPVFSA HHSETEMLRY LKQLENKDLA 500
    LNQSMIPLGS CTMKLNASSE MIPITWPEFA NLHPFAPREQ AAGYGLLIAE 550
    LERWLCAITG FDAICMQPNS GAQGEYAGLL AIRRYHESRR QGGRHVCLIP 600
    ASAHGTNPAS AQMAGMQVVI VECDEAGNVD LEDLKAKAQA AGERLSCLMA 650
    TYPSTHGVYE EGISQICEVI HSHGGQVYMD GANLNAQVGL ARPADIGADV 700
    SHMNLHKTFC IPHGGGGPGM GPIGVRAHLA PFVANHPVVP IDGPLPENGA 750
    VSAAPWGSAS ILPISWMYIA LMGPQLADAS EVAILAANYL AEQLSGAFPV 800
    LYSGRNGRVA HECILDLRPL KAQTGISEED VAKRLMDYGF HAPTMSFPVP 850
    GTLMVEPTES ESKAELDRFI EAMLSIRAEI AQVQEGNWPA EDNPLKGAPH 900
    TLADITGVWE RSYSIEQAVL PTAHTRAHKY WPAVNRVDNV YGDRNLFCAC 950
    VPLADYR 957
    Length:957
    Mass (Da):103,724
    Last modified:March 21, 2012 - v2
    Checksum:i9C80D645FCCA4F57
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY95149.2.
    RefSeqiYP_263017.2. NC_004129.6.

    Genome annotation databases

    EnsemblBacteriaiAAY95149; AAY95149; PFL_5959.
    GeneIDi3480331.
    KEGGipfl:PFL_5959.
    PATRICi19881431. VBIPseFlu72549_6076.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY95149.2 .
    RefSeqi YP_263017.2. NC_004129.6.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220664.PFL_5959.

    Proteomic databases

    PRIDEi Q4K416.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY95149 ; AAY95149 ; PFL_5959 .
    GeneIDi 3480331.
    KEGGi pfl:PFL_5959.
    PATRICi 19881431. VBIPseFlu72549_6076.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.

    Enzyme and pathway databases

    BioCyci PFLU220664:GIX8-6001-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf-5 / ATCC BAA-477.

    Entry informationi

    Entry nameiGCSP2_PSEF5
    AccessioniPrimary (citable) accession number: Q4K416
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 61 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3