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Q4K416 (GCSP2_PSEF5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating) 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein 2
Glycine decarboxylase 2
Glycine dehydrogenase (aminomethyl-transferring) 2
Gene names
Name:gcvP2
Ordered Locus Names:PFL_5959
OrganismPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP]
Taxonomic identifier220664 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length957 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 957957Glycine dehydrogenase (decarboxylating) 2 HAMAP-Rule MF_00711
PRO_0000227117

Amino acid modifications

Modified residue7071N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4K416 [UniParc].

Last modified March 21, 2012. Version 2.
Checksum: 9C80D645FCCA4F57

FASTA957103,724
        10         20         30         40         50         60 
MSQLLSLSQL REPNAFLNRH LGPDAEEQQA MLASLGLGSR AELIEQTVPP GIRFNRALDL 

        70         80         90        100        110        120 
PPALDEAAAL ARLKGYAGQN QVWTSLIGMG YHATLTPTVI LRNVLENPGW YTAYTPYQPE 

       130        140        150        160        170        180 
IAQGRLEALL NFQQMTIDLT GLDLANASLL DEATAAAEAM ALAKRVSKSS SNLFFVDEHC 

       190        200        210        220        230        240 
HPQTVSVVRT RAEGFGFELV VGGVDELSGH QVFGALLQYP DTHGEIRDLR PLIDQLHAQQ 

       250        260        270        280        290        300 
ALACVAADLL SLLLLTPPGE LGADVVLGSS QRFGVPMGYG GPHAAFFACR DDYKRAMPGR 

       310        320        330        340        350        360 
IIGVSKDARG QVALRMALQT REQHIRREKA NSNICTAQVL LANIAGFYAV YHGPAGLKRI 

       370        380        390        400        410        420 
AQRVHRLTCI LAVGLERHGI ARVNRHFFDT LTLEVGGSQT AIIESARAQQ INLRILGRGR 

       430        440        450        460        470        480 
LGLSLDETCD ESTVTRLFDV FLGADHGLDV SNLDAEALES GIPDPLLRRT RYLTHPVFSA 

       490        500        510        520        530        540 
HHSETEMLRY LKQLENKDLA LNQSMIPLGS CTMKLNASSE MIPITWPEFA NLHPFAPREQ 

       550        560        570        580        590        600 
AAGYGLLIAE LERWLCAITG FDAICMQPNS GAQGEYAGLL AIRRYHESRR QGGRHVCLIP 

       610        620        630        640        650        660 
ASAHGTNPAS AQMAGMQVVI VECDEAGNVD LEDLKAKAQA AGERLSCLMA TYPSTHGVYE 

       670        680        690        700        710        720 
EGISQICEVI HSHGGQVYMD GANLNAQVGL ARPADIGADV SHMNLHKTFC IPHGGGGPGM 

       730        740        750        760        770        780 
GPIGVRAHLA PFVANHPVVP IDGPLPENGA VSAAPWGSAS ILPISWMYIA LMGPQLADAS 

       790        800        810        820        830        840 
EVAILAANYL AEQLSGAFPV LYSGRNGRVA HECILDLRPL KAQTGISEED VAKRLMDYGF 

       850        860        870        880        890        900 
HAPTMSFPVP GTLMVEPTES ESKAELDRFI EAMLSIRAEI AQVQEGNWPA EDNPLKGAPH 

       910        920        930        940        950 
TLADITGVWE RSYSIEQAVL PTAHTRAHKY WPAVNRVDNV YGDRNLFCAC VPLADYR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000076 Genomic DNA. Translation: AAY95149.2.
RefSeqYP_263017.2. NC_004129.6.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220664.PFL_5959.

Proteomic databases

PRIDEQ4K416.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY95149; AAY95149; PFL_5959.
GeneID3480331.
KEGGpfl:PFL_5959.
PATRIC19881431. VBIPseFlu72549_6076.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.

Enzyme and pathway databases

BioCycPFLU220664:GIX8-6001-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP2_PSEF5
AccessionPrimary (citable) accession number: Q4K416
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 21, 2012
Last modified: May 14, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families