SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4K416

- GCSP2_PSEF5

UniProt

Q4K416 - GCSP2_PSEF5

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glycine dehydrogenase (decarboxylating) 2
Gene
gcvP2, PFL_5959
Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-6001-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein 2
Glycine decarboxylase 2
Glycine dehydrogenase (aminomethyl-transferring) 2
Gene namesi
Name:gcvP2
Ordered Locus Names:PFL_5959
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008540: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Glycine dehydrogenase (decarboxylating) 2UniRule annotation
PRO_0000227117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei707 – 7071N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ4K416.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi220664.PFL_5959.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4K416-1 [UniParc]FASTAAdd to Basket

« Hide

MSQLLSLSQL REPNAFLNRH LGPDAEEQQA MLASLGLGSR AELIEQTVPP    50
GIRFNRALDL PPALDEAAAL ARLKGYAGQN QVWTSLIGMG YHATLTPTVI 100
LRNVLENPGW YTAYTPYQPE IAQGRLEALL NFQQMTIDLT GLDLANASLL 150
DEATAAAEAM ALAKRVSKSS SNLFFVDEHC HPQTVSVVRT RAEGFGFELV 200
VGGVDELSGH QVFGALLQYP DTHGEIRDLR PLIDQLHAQQ ALACVAADLL 250
SLLLLTPPGE LGADVVLGSS QRFGVPMGYG GPHAAFFACR DDYKRAMPGR 300
IIGVSKDARG QVALRMALQT REQHIRREKA NSNICTAQVL LANIAGFYAV 350
YHGPAGLKRI AQRVHRLTCI LAVGLERHGI ARVNRHFFDT LTLEVGGSQT 400
AIIESARAQQ INLRILGRGR LGLSLDETCD ESTVTRLFDV FLGADHGLDV 450
SNLDAEALES GIPDPLLRRT RYLTHPVFSA HHSETEMLRY LKQLENKDLA 500
LNQSMIPLGS CTMKLNASSE MIPITWPEFA NLHPFAPREQ AAGYGLLIAE 550
LERWLCAITG FDAICMQPNS GAQGEYAGLL AIRRYHESRR QGGRHVCLIP 600
ASAHGTNPAS AQMAGMQVVI VECDEAGNVD LEDLKAKAQA AGERLSCLMA 650
TYPSTHGVYE EGISQICEVI HSHGGQVYMD GANLNAQVGL ARPADIGADV 700
SHMNLHKTFC IPHGGGGPGM GPIGVRAHLA PFVANHPVVP IDGPLPENGA 750
VSAAPWGSAS ILPISWMYIA LMGPQLADAS EVAILAANYL AEQLSGAFPV 800
LYSGRNGRVA HECILDLRPL KAQTGISEED VAKRLMDYGF HAPTMSFPVP 850
GTLMVEPTES ESKAELDRFI EAMLSIRAEI AQVQEGNWPA EDNPLKGAPH 900
TLADITGVWE RSYSIEQAVL PTAHTRAHKY WPAVNRVDNV YGDRNLFCAC 950
VPLADYR 957
Length:957
Mass (Da):103,724
Last modified:March 21, 2012 - v2
Checksum:i9C80D645FCCA4F57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY95149.2.
RefSeqiYP_263017.2. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY95149; AAY95149; PFL_5959.
GeneIDi3480331.
KEGGipfl:PFL_5959.
PATRICi19881431. VBIPseFlu72549_6076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000076 Genomic DNA. Translation: AAY95149.2 .
RefSeqi YP_263017.2. NC_004129.6.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220664.PFL_5959.

Proteomic databases

PRIDEi Q4K416.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY95149 ; AAY95149 ; PFL_5959 .
GeneIDi 3480331.
KEGGi pfl:PFL_5959.
PATRICi 19881431. VBIPseFlu72549_6076.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.

Enzyme and pathway databases

BioCyci PFLU220664:GIX8-6001-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiGCSP2_PSEF5
AccessioniPrimary (citable) accession number: Q4K416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 21, 2012
Last modified: May 14, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi