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Q4K3E8 (GCH4_PSEF5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:PFL_6177
OrganismPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) [Complete proteome] [HAMAP]
Taxonomic identifier220664 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289509

Sites

Site1491May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4K3E8 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: CC11E7B5B3D4FC8B

FASTA29732,705
        10         20         30         40         50         60 
MNALTLPDIA AQASRQTLPL EWVGMCGIAL PVVINNQPSA AKADAGVSLD DGEARGIHMS 

        70         80         90        100        110        120 
RLYLALEMLE QENLTPALLR RILQRFLDSH EGLAHSAYLR IQLDLLLKRP ALVSPLAGWK 

       130        140        150        160        170        180 
SYPLSIEARL KNAMFHVELK IDVPYSSTCP CSAALARQLI QQQFIEDFAN RPLQHADVLA 

       190        200        210        220        230        240 
WLGSPQGVVA TPHSQRSNAA LHLRLDDFID ELPLIALIND AENALGTAVQ TAVKRADEQA 

       250        260        270        280        290 
FALANGQNLM FCEDAARRLN LALRRSPGIN AFQLRVVHAE SLHAHDAVAE SRWNWEA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000076 Genomic DNA. Translation: AAY95365.1.
RefSeqYP_263235.1. NC_004129.6.

3D structure databases

ProteinModelPortalQ4K3E8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220664.PFL_6177.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY95365; AAY95365; PFL_6177.
GeneID3480547.
KEGGpfl:PFL_6177.
PATRIC19881891. VBIPseFlu72549_6306.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OMARCLNGAF.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycPFLU220664:GIX8-6220-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_PSEF5
AccessionPrimary (citable) accession number: Q4K3E8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways