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Q4K3E8

- GCH4_PSEF5

UniProt

Q4K3E8 - GCH4_PSEF5

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1491May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPFLU220664:GIX8-6220-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:PFL_6177
OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008540: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297GTP cyclohydrolase FolE2PRO_0000289509Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220664.PFL_6177.

Structurei

3D structure databases

ProteinModelPortaliQ4K3E8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiRCLNGAF.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4K3E8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNALTLPDIA AQASRQTLPL EWVGMCGIAL PVVINNQPSA AKADAGVSLD
60 70 80 90 100
DGEARGIHMS RLYLALEMLE QENLTPALLR RILQRFLDSH EGLAHSAYLR
110 120 130 140 150
IQLDLLLKRP ALVSPLAGWK SYPLSIEARL KNAMFHVELK IDVPYSSTCP
160 170 180 190 200
CSAALARQLI QQQFIEDFAN RPLQHADVLA WLGSPQGVVA TPHSQRSNAA
210 220 230 240 250
LHLRLDDFID ELPLIALIND AENALGTAVQ TAVKRADEQA FALANGQNLM
260 270 280 290
FCEDAARRLN LALRRSPGIN AFQLRVVHAE SLHAHDAVAE SRWNWEA
Length:297
Mass (Da):32,705
Last modified:August 2, 2005 - v1
Checksum:iCC11E7B5B3D4FC8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY95365.1.
RefSeqiYP_263235.1. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY95365; AAY95365; PFL_6177.
GeneIDi3480547.
KEGGipfl:PFL_6177.
PATRICi19881891. VBIPseFlu72549_6306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY95365.1 .
RefSeqi YP_263235.1. NC_004129.6.

3D structure databases

ProteinModelPortali Q4K3E8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220664.PFL_6177.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY95365 ; AAY95365 ; PFL_6177 .
GeneIDi 3480547.
KEGGi pfl:PFL_6177.
PATRICi 19881891. VBIPseFlu72549_6306.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi RCLNGAF.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci PFLU220664:GIX8-6220-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pf-5 / ATCC BAA-477.

Entry informationi

Entry nameiGCH4_PSEF5
AccessioniPrimary (citable) accession number: Q4K3E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 2, 2005
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3