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Q4K3E8

- GCH4_PSEF5

UniProt

Q4K3E8 - GCH4_PSEF5

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei149 – 1491May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPFLU220664:GIX8-6220-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:PFL_6177
    OrganismiPseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
    Taxonomic identifieri220664 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000008540: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297GTP cyclohydrolase FolE2PRO_0000289509Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi220664.PFL_6177.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4K3E8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiRCLNGAF.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4K3E8-1 [UniParc]FASTAAdd to Basket

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    MNALTLPDIA AQASRQTLPL EWVGMCGIAL PVVINNQPSA AKADAGVSLD    50
    DGEARGIHMS RLYLALEMLE QENLTPALLR RILQRFLDSH EGLAHSAYLR 100
    IQLDLLLKRP ALVSPLAGWK SYPLSIEARL KNAMFHVELK IDVPYSSTCP 150
    CSAALARQLI QQQFIEDFAN RPLQHADVLA WLGSPQGVVA TPHSQRSNAA 200
    LHLRLDDFID ELPLIALIND AENALGTAVQ TAVKRADEQA FALANGQNLM 250
    FCEDAARRLN LALRRSPGIN AFQLRVVHAE SLHAHDAVAE SRWNWEA 297
    Length:297
    Mass (Da):32,705
    Last modified:August 2, 2005 - v1
    Checksum:iCC11E7B5B3D4FC8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY95365.1.
    RefSeqiYP_263235.1. NC_004129.6.

    Genome annotation databases

    EnsemblBacteriaiAAY95365; AAY95365; PFL_6177.
    GeneIDi3480547.
    KEGGipfl:PFL_6177.
    PATRICi19881891. VBIPseFlu72549_6306.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000076 Genomic DNA. Translation: AAY95365.1 .
    RefSeqi YP_263235.1. NC_004129.6.

    3D structure databases

    ProteinModelPortali Q4K3E8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220664.PFL_6177.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY95365 ; AAY95365 ; PFL_6177 .
    GeneIDi 3480547.
    KEGGi pfl:PFL_6177.
    PATRICi 19881891. VBIPseFlu72549_6306.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi RCLNGAF.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci PFLU220664:GIX8-6220-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pf-5 / ATCC BAA-477.

    Entry informationi

    Entry nameiGCH4_PSEF5
    AccessioniPrimary (citable) accession number: Q4K3E8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3