ID   HIS32_PSEF5             Reviewed;         147 AA.
AC   Q4K3E4;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Phosphoribosyl-AMP cyclohydrolase 2;
DE            Short=PRA-CH 2;
DE            EC=3.5.4.19;
GN   Name=hisI2; OrderedLocusNames=PFL_6181;
OS   Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=220664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15980861; DOI=10.1038/nbt1110;
RA   Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A.,
RA   Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J.,
RA   Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A.,
RA   Rosovitz M.J., Gwinn M.L., Zhou L., Schneider D.J., Cartinhour S.W.,
RA   Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A.,
RA   Pierson L.S. III, Thomashow L.S., Loper J.E.;
RT   "Complete genome sequence of the plant commensal Pseudomonas
RT   fluorescens Pf-5.";
RL   Nat. Biotechnol. 23:873-878(2005).
CC   -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5-
CC       phosphoribosyl)-5-((5-
CC       phosphoribosylamino)methylideneamino)imidazole-4-carboxamide.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the PRA-CH family.
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DR   EMBL; CP000076; AAY95369.1; -; Genomic_DNA.
DR   RefSeq; YP_263239.1; -.
DR   GeneID; 3480551; -.
DR   GenomeReviews; CP000076_GR; PFL_6181.
DR   KEGG; pfl:PFL_6181; -.
DR   NMPDR; fig|220664.3.peg.109; -.
DR   HOGENOM; Q4K3E4; -.
DR   OMA; Q4K3E4; LMVANMN.
DR   BioCyc; PFLU220664:PFL_6181-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004635; F:phosphoribosyl-AMP cyclohydrolase activity; IEA:HAMAP.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01021; -; 1.
DR   InterPro; IPR002496; PRA_CycHdrlase.
DR   Pfam; PF01502; PRA-CH; 1.
DR   ProDom; PD002610; PRA_cyclohydro; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Hydrolase.
FT   CHAIN         1    147       Phosphoribosyl-AMP cyclohydrolase 2.
FT                                /FTId=PRO_0000229835.
SQ   SEQUENCE   147 AA;  16205 MW;  E35D31123EE8DDF5 CRC64;
     MIRRPPLSLL DLEAAPLGSR WALTAVLDAL PWNSDGLIAA IAQQHDSGEV LMLAWMNRQA
     LGETLASGQA CYWSRSRRCL WRKGESSGHR QRLIEARLDC DGDAVLLLVD QQGPACHTGR
     PNCFYNAIRD GAVEVISSPL KDSRHDS
//