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Protein

Cardiolipin synthase A

Gene

clsA

Organism
Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei223UniRule annotation1
Active sitei225UniRule annotation1
Active sitei230UniRule annotation1
Active sitei397UniRule annotation1
Active sitei399UniRule annotation1
Active sitei404UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciPPRO220664:G1G4K-6367-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
Ordered Locus Names:PFL_6186
OrganismiPseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000008540 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalUniRule annotationAdd BLAST21
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000775021 – 479Cardiolipin synthase AAdd BLAST479

Proteomic databases

PRIDEiQ4K3D9

Interactioni

Protein-protein interaction databases

STRINGi220664.PFL_6186

Structurei

3D structure databases

ProteinModelPortaliQ4K3D9
SMRiQ4K3D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 245PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini392 – 419PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CQX Bacteria
COG1502 LUCA
HOGENOMiHOG000077402
KOiK06131
OMAiGGHNVGD
OrthoDBiPOG091H04OR

Family and domain databases

HAMAPiMF_00190 Cardiolipin_synth_ClsA, 1 hit
InterProiView protein in InterPro
IPR022924 Cardiolipin_synthase
IPR030840 CL_synthase_A
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

Q4K3D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYFGPHIFG YLIALLHFLG LIAAIHAVLT VRTAQGAIAW ALSLLFMPYL
60 70 80 90 100
TLIPYLVFGR STFDAYIQAR RQANVEMHKA INELNWRPWV EEALTARASK
110 120 130 140 150
AYASLRAMPK LGRMPCLANN QVRLLVNGDA TFEAIFNAIR RSHKAVLIQF
160 170 180 190 200
FIIHDDDLGR RLQRLLLEKA AEGVSIHLLY DRIGSHSLPA SYVQTLRDAG
210 220 230 240 250
VQVHAFATRS GWLNRFQVNF RNHRKIVVVD GMLGFVGGHN VGDEYLGKKP
260 270 280 290 300
PLAPWRDTHV QVSGPVVACL QESFAEDWFW AARELPPLIL PDTYPDDGVL
310 320 330 340 350
CQLLASGPAD AYETCSLFFV EAIHAATERV WITSPYFIPD EAVFAALRLA
360 370 380 390 400
VLRDVDVRIL LPARPDHRIV YAASSLYAFE AVRAGVRVFR YQPGFLHQKV
410 420 430 440 450
VLIDNEISAI GSANLDNRSF RLNFEVMLLT VDDDFATEVE HMLEADFAKA
460 470
REIAKEESRQ THRLQQLGMR VARLISPIL
Length:479
Mass (Da):53,996
Last modified:August 2, 2005 - v1
Checksum:i0918876F6AD9688F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA Translation: AAY95374.1
RefSeqiWP_011064351.1, NC_004129.6

Genome annotation databases

EnsemblBacteriaiAAY95374; AAY95374; PFL_6186
KEGGipfl:PFL_6186
PATRICifig|220664.5.peg.6315

Similar proteinsi

Entry informationi

Entry nameiCLSA_PSEF5
AccessioniPrimary (citable) accession number: Q4K3D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 2, 2005
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health