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Protein

Cardiolipin synthase A

Gene

clsA

Organism
Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei223UniRule annotation1
Active sitei225UniRule annotation1
Active sitei230UniRule annotation1
Active sitei397UniRule annotation1
Active sitei399UniRule annotation1
Active sitei404UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
Ordered Locus Names:PFL_6186
OrganismiPseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Taxonomic identifieri220664 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000008540 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalUniRule annotationAdd BLAST21
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000775021 – 479Cardiolipin synthase AAdd BLAST479

Proteomic databases

PRIDEiQ4K3D9.

Interactioni

Protein-protein interaction databases

STRINGi220664.PFL_6186.

Structurei

3D structure databases

ProteinModelPortaliQ4K3D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 245PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini392 – 419PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation
Contains 2 PLD phosphodiesterase domains.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CQX. Bacteria.
COG1502. LUCA.
HOGENOMiHOG000077402.
KOiK06131.
OMAiSFAEDWF.
OrthoDBiPOG091H04OR.

Family and domain databases

HAMAPiMF_00190. Cardiolipin_synth_ClsA. 1 hit.
InterProiIPR022924. Cardiolipin_synthase.
IPR030840. CL_synthase_A.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4K3D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYFGPHIFG YLIALLHFLG LIAAIHAVLT VRTAQGAIAW ALSLLFMPYL
60 70 80 90 100
TLIPYLVFGR STFDAYIQAR RQANVEMHKA INELNWRPWV EEALTARASK
110 120 130 140 150
AYASLRAMPK LGRMPCLANN QVRLLVNGDA TFEAIFNAIR RSHKAVLIQF
160 170 180 190 200
FIIHDDDLGR RLQRLLLEKA AEGVSIHLLY DRIGSHSLPA SYVQTLRDAG
210 220 230 240 250
VQVHAFATRS GWLNRFQVNF RNHRKIVVVD GMLGFVGGHN VGDEYLGKKP
260 270 280 290 300
PLAPWRDTHV QVSGPVVACL QESFAEDWFW AARELPPLIL PDTYPDDGVL
310 320 330 340 350
CQLLASGPAD AYETCSLFFV EAIHAATERV WITSPYFIPD EAVFAALRLA
360 370 380 390 400
VLRDVDVRIL LPARPDHRIV YAASSLYAFE AVRAGVRVFR YQPGFLHQKV
410 420 430 440 450
VLIDNEISAI GSANLDNRSF RLNFEVMLLT VDDDFATEVE HMLEADFAKA
460 470
REIAKEESRQ THRLQQLGMR VARLISPIL
Length:479
Mass (Da):53,996
Last modified:August 2, 2005 - v1
Checksum:i0918876F6AD9688F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY95374.1.
RefSeqiWP_011064351.1. NC_004129.6.

Genome annotation databases

EnsemblBacteriaiAAY95374; AAY95374; PFL_6186.
GeneIDi3480556.
KEGGipfl:PFL_6186.
PATRICi19881909. VBIPseFlu72549_6315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000076 Genomic DNA. Translation: AAY95374.1.
RefSeqiWP_011064351.1. NC_004129.6.

3D structure databases

ProteinModelPortaliQ4K3D9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220664.PFL_6186.

Proteomic databases

PRIDEiQ4K3D9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY95374; AAY95374; PFL_6186.
GeneIDi3480556.
KEGGipfl:PFL_6186.
PATRICi19881909. VBIPseFlu72549_6315.

Phylogenomic databases

eggNOGiENOG4105CQX. Bacteria.
COG1502. LUCA.
HOGENOMiHOG000077402.
KOiK06131.
OMAiSFAEDWF.
OrthoDBiPOG091H04OR.

Family and domain databases

HAMAPiMF_00190. Cardiolipin_synth_ClsA. 1 hit.
InterProiIPR022924. Cardiolipin_synthase.
IPR030840. CL_synthase_A.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLSA_PSEF5
AccessioniPrimary (citable) accession number: Q4K3D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 2, 2005
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.