Q4JYE7 (Q4JYE7_CORJK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL CAI36160.1
Ordered Locus Names:	jk0011

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	837 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4JYE7 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: E0C39EFC5083C8F3	FASTA	837	93,088
	10 20 30 40 50 60 MSDDNNGSDN LFDRVTPIDL QEEMKSSYID YAMSVIVGRA LPEVRDGLKP VHRRILYAMF 70 80 90 100 110 120 DNGYRPERSY VKSAKPVADT MGNYHPHGDS AIYDTLVRLA QPWSMRYPLV DGQGNFGSRG 130 140 150 160 170 180 NDGAAAMRYT ECRMTPLAME MVRDIRENTV EFQPNYDGKT TEPTVLPSRV PNLLMNGSGG 190 200 210 220 230 240 IAVGMATNIP PHNLNELAEA IYWLLDNPDA EEADALEACM ERVKGPDFPT AGLIVGDKGI 250 260 270 280 290 300 QDTYRTGRGS IRMRGVTSIE EEGNRQVIII TELPYQVNPD NLVASIAEQI RDGKIAGISK 310 320 330 340 350 360 IDDESSDRVG MRIVITLKRD AVPRVVLNNL YKHSQLQTSF GSNMLSIVDG VPRTLRLDQM 370 380 390 400 410 420 LRHYVDHQID VIVRRTQFRL DEAEKRAHIL RGLVKALDML DEVIALIRRS PTVDEARTGL 430 440 450 460 470 480 IDLLDVDEVQ ADHILAMQLR RLAAMERQKI IDELAELEET IADLKAILES PQRQRDIVRT 490 500 510 520 530 540 ELAEIVDKYG DERRTQIIAA SGDVSEEDLI ARENVVVTIT STGYAKRTKV DSYRSQRRGG 550 560 570 580 590 600 KGVRGAELKQ DDVVRHFFVC STHDTILFFT NFGRVYRLRA FELPEATRTA RGQHVANLLE 610 620 630 640 650 660 FQPGEQIAQV IQIQSYEDAP YLVLATAHGR VKKSRLTDYD TARSGGLIAI NLNEGDRLVG 670 680 690 700 710 720 AQLCTAEDDL LLVSEEGQAM RFTADDETLR PMGRATAGVK GMRFREEDQL LALTVVAEDS 730 740 750 760 770 780 SLFVATSGGY GKRTPMEEYP TKGRGGLGVV AFKYDKKRGK LIGALTVNDD DEILAMTSNG 790 800 810 820 830 GVIRTEVSQI RHSGRATMGV RLVDLAKGNE LVAVDRNVEE EAEESAEATA KAETESE

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K411.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR931997 Genomic DNA. Translation: CAI36160.1.
RefSeq	YP_249778.1. NC_007164.1.
3D structure databases
ProteinModelPortal	Q4JYE7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JYE7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3433799.
GenomeReviews	Gene locus jk0011 in contig CR931997_GR.
KEGG	cjk:jk0011.
NMPDR	fig|306537.3.peg.1698.
PATRIC	21510866. VBICorJei31838_0021.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0188.
HOGENOM	HBG635183.
OMA	TGRGRIY.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q4JYE7_CORJK

Accession

Primary (citable) accession number: Q4JYE7

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)