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Q4JY04

- PCKG_CORJK

UniProt

Q4JY04 - PCKG_CORJK

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei79 – 791SubstrateUniRule annotation
    Binding sitei220 – 2201Substrate; via amide nitrogenUniRule annotation
    Metal bindingi227 – 2271ManganeseUniRule annotation
    Binding sitei227 – 2271SubstrateUniRule annotation
    Metal bindingi247 – 2471Manganese; via tele nitrogenUniRule annotation
    Binding sitei269 – 2691SubstrateUniRule annotation
    Active sitei271 – 2711UniRule annotation
    Metal bindingi294 – 2941ManganeseUniRule annotation
    Binding sitei386 – 3861GTPUniRule annotation
    Binding sitei417 – 4171GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi270 – 2756GTPUniRule annotation
    Nucleotide bindingi512 – 5154GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCJEI306537:GJ8V-157-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Synonyms:pck
    Ordered Locus Names:jk0151
    OrganismiCorynebacterium jeikeium (strain K411)
    Taxonomic identifieri306537 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000545: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 606606Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103604Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi306537.jk0151.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4JY04.
    SMRiQ4JY04. Positions 10-602.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni384 – 3863Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiINTEGLG.
    OrthoDBiEOG6MPWQS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4JY04-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIRGLVGEA PTKNQEMLNW IEEAVELFQP ESVVFCDGSE EEWNELAEQL    50
    VEHGTLIKLD EEAQPNSFLA RSNPSDVARV ESRTFICSKT EEDAGPTNNW 100
    MDPEQMRAEM REHFSGSMKG RRMYIVPFCM GPITDPSPKL GIEITDSPYV 150
    VMSMRIMTRM GKEALDKIGE NGEFVKGLHS VGAPLEPGQE DSTWPCNDTK 200
    YITHFPEDRE IWSYGSGYGG NAILAKKCYA LRIASAMARD EGWMAEHMLI 250
    LKLISPEDKA YYICAAFPSA CGKTNLAMIQ PTIPGWRAEV VGDDIAWLHF 300
    GEDGRLYAVN PENGFFGVAP GTNYASNPMA MKSMEPGNTL YTNVALTDDN 350
    NVWWESKEGE PQHLIDWLGN EWTPDSGNKA AHPNSRYCVP IEQCPVAAPE 400
    FNDPKGVPVS AILFGGRRAD TVPLVTQARD WNHATFIGAT LASGQTAAAA 450
    EAAVGSLRHD PMAMLPFIGY NAGDYLQHWI DMGNKGGDKM PEVFLVNWFR 500
    RGEDGRFLWP GFGENSRVLK WIIDRIEGRV EADETVVGYT ARYEDIYTDG 550
    LKETEEDIRE ALSVNPADWE RDLADNEEWL KFLGPKVPSE VWDEFQGLKD 600
    RVEAAK 606
    Length:606
    Mass (Da):67,733
    Last modified:August 2, 2005 - v1
    Checksum:iC4724EC230EC42A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR931997 Genomic DNA. Translation: CAI36303.1.
    RefSeqiYP_249921.1. NC_007164.1.

    Genome annotation databases

    EnsemblBacteriaiCAI36303; CAI36303; jk0151.
    GeneIDi3432866.
    KEGGicjk:jk0151.
    PATRICi21511164. VBICorJei31838_0164.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR931997 Genomic DNA. Translation: CAI36303.1 .
    RefSeqi YP_249921.1. NC_007164.1.

    3D structure databases

    ProteinModelPortali Q4JY04.
    SMRi Q4JY04. Positions 10-602.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 306537.jk0151.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI36303 ; CAI36303 ; jk0151 .
    GeneIDi 3432866.
    KEGGi cjk:jk0151.
    PATRICi 21511164. VBICorJei31838_0164.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi INTEGLG.
    OrthoDBi EOG6MPWQS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci CJEI306537:GJ8V-157-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
      Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
      J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K411.

    Entry informationi

    Entry nameiPCKG_CORJK
    AccessioniPrimary (citable) accession number: Q4JY04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3