Q4JXU5 (GCST_CORJK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	jk0210

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Aminomethyltransferase HAMAP MF_00259		PRO_1000047660

Sequences

	Sequence		Length	Mass (Da)
	Q4JXU5 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: EB6B4466CF614591	FASTA	389	40,653
	10 20 30 40 50 60 MTELKKTALH LVHEKLGARF TDFGGWDMPL KYSSELDEHH AVRNAVGVFD LSHMGEVRVT 70 80 90 100 110 120 GPQAAEFLDH ALISKLSAVK VGKAKYSMIC TESGGIIDDL ITYRLGDNEF LIVPNAGNVD 130 140 150 160 170 180 NVVSALQGRT EGFDVEVNNE SDATSMIAVQ GPKAAQAMLE IVENVVDAPE ASGAGETVAE 190 200 210 220 230 240 AIEGLGYYAA FSGVAAGQPV LVARTGYTGE DGFELIVAND GAETVWTKAM DQAAQLGGLP 250 260 270 280 290 300 CGLACRDTLR LEAGMPLYGN ELSLKLTPVD AGLGILAATK SKDSFVGRDA IVSAKEKGTQ 310 320 330 340 350 360 QVLIGLAGEG RRAARGGYEV FAGDGEKAIG AVTSGALSPT LGHPVALAYV AKSAVSSGAA 370 380 AEGATVEVDI RGKRFEYKVV ALPFYSREK

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K411.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR931997 Genomic DNA. Translation: CAI36362.1.
RefSeq	YP_249980.1. NC_007164.1.
3D structure databases
HSSP	HSSP built from PDB template 1VLO based on UniProtKB P27248.
ProteinModelPortal	Q4JXU5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JXU5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3433828.
GenomeReviews	Gene locus jk0210 in contig CR931997_GR.
KEGG	cjk:jk0210.
NMPDR	fig|306537.3.peg.519.
PATRIC	21511276. VBICorJei31838_0220.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	GWEMPIS.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	CJEI306537:JK0210-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_CORJK

Accession

Primary (citable) accession number: Q4JXU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program