Q4JXS1 (Q4JXS1_CORJK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Methionine synthase EMBL CAI36386.1
EC=2.1.1.14 EMBL CAI36386.1

Gene names

Name:	metE EMBL CAI36386.1
Ordered Locus Names:	jk0234

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	772 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. SAAS SAAS013215
Catalytic activity	5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. SAAS SAAS013215
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. SAAS SAAS013215

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Methionine biosynthesis SAAS SAAS013215
Ligand	Metal-binding SAAS SAAS013215 Zinc SAAS SAAS013215
Molecular function	Methyltransferase SAAS SAAS013215 EMBL CAI36386.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4JXS1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 726C4DB9FAD218A4	FASTA	772	84,948
	10 20 30 40 50 60 MTFNATVAGV PRIGPDRELK KALEGYWRDN STGRNLATTA TRLVNDYTDE LLAAGLDSAA 70 80 90 100 110 120 FSGRSFYDAV LDTTALLGLL PERVADIADH DNDGLPRFID RYFAAARGTK ELPASAMTKW 130 140 150 160 170 180 FDTNYHYIVP ELAKDSRVEL DDSAFLEDIR DQVTRAGEAV RPVLVGPLTY LALSRTVDGS 190 200 210 220 230 240 DAFAHLEEIF DAYSRLLKRI ADRGVKWVQF DEPILVTDFA YADAAANEDL LKRTRAGYEK 250 260 270 280 290 300 LVEAAGAGDE GVNLLIQTYF GDGNAAIELL SGSGVAAFGV DLVTGGAAAA ELPAWNGKEL 310 320 330 340 350 360 LAAGVVDGHN VWRTDLDAAL KTLQGLKERG PVAVSTSCSL LHVPYSLQRE QNLNAEVQKW 370 380 390 400 410 420 LAFGSEKIRE VAALSRTLRG EQTEADEQLF AETREAIEDR KNSTLTHNAA VRERQDAVTD 430 440 450 460 470 480 ADRRRDSIEA RREAQKAELN LPPLPTTTIG SFPQTTEIRQ ARAKHRKGEI DDAAYTQAMK 490 500 510 520 530 540 DEVADVIKRQ EELGLDVLVH GEPERNDMVQ YFSEQLDGYL STEHAWVQSY GSRCVRPPII 550 560 570 580 590 600 FGDVSRPHAM TVDWYKVAAD LTDKPVKGML TGPVTMLAWS FVRDDQPLGE TADQVALALR 610 620 630 640 650 660 DEIDDLIAAG ARVVQVDEPA IRELLPLRKE QQPDYLKWAV GSFRLATSGA ENKVQIHTHM 670 680 690 700 710 720 CYSEFNELID TVSNLDADVT SIEAARNGMQ VLAALKDEGY ELGVGPGVWD IHSPRVPKQQ 730 740 750 760 770 EVDDLLSAAL DSVDPSLLWV NPDCGLKTRG WEETTASLEV LVSAAKKARE RV

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K411.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR931997 Genomic DNA. Translation: CAI36386.1.
RefSeq	YP_250004.1. NC_007164.1.
3D structure databases
ProteinModelPortal	Q4JXS1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JXS1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3433304.
GenomeReviews	Gene locus jk0234 in contig CR931997_GR.
KEGG	cjk:jk0234.
NMPDR	fig|306537.3.peg.666.
PATRIC	21511324. VBICorJei31838_0244.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0620.
HOGENOM	HBG287495.
OMA	RNIWRAN.
ProtClustDB	PRK05222.
Family and domain databases
InterPro	IPR013215. Cbl-indep_Met_Synth_N. IPR006276. Cobalamin-indep_Met_synthase. IPR002629. Methionine_synth. [Graphical view]
KO	K00549.
Pfam	PF08267. Meth_synt_1. 1 hit. PF01717. Meth_synt_2. 1 hit. [Graphical view]
PIRSF	PIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMs	TIGR01371. Met_syn_B12ind. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q4JXS1_CORJK

Accession

Primary (citable) accession number: Q4JXS1

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)