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Q4JXL9

- PANC_CORJK

UniProt

Q4JXL9 - PANC_CORJK

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Protein

Pantothenate synthetase

Gene

panC

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton donorUniRule annotation
Binding sitei69 – 691Beta-alanineUniRule annotation
Binding sitei69 – 691PantoateUniRule annotation
Binding sitei161 – 1611PantoateUniRule annotation
Binding sitei184 – 1841ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448ATPUniRule annotation
Nucleotide bindingi155 – 1584ATPUniRule annotation
Nucleotide bindingi192 – 1954ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEI306537:GJ8V-292-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:jk0286
OrganismiCorynebacterium jeikeium (strain K411)
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000545: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Pantothenate synthetasePRO_0000305431Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi306537.jk0286.

Structurei

3D structure databases

ProteinModelPortaliQ4JXL9.
SMRiQ4JXL9. Positions 2-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiPTHFAGM.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4JXL9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTFTPGQAEV FTEIEKIGQL TRAMRKAGRP VALVPTMGAL HEGHLSLVQA
60 70 80 90 100
AQQIPGALVV VSIFVNPLQF AEGEDLDAYP RTLDEDVAKL KAAGVDAVFA
110 120 130 140 150
PSPREMYPNG PRTTIHPGEA GRILEGAHRP THFAGVLTVV NKLFTITHCD
160 170 180 190 200
HAFFGEKDYQ QLLLIQQIVT DLNMEVQVHG VPIVREADGL AKSSRNVYLS
210 220 230 240 250
DEERELALTL SAALTAGAFV AEQGPAAVLQ TAGSILDAAS GIDVDYLELR
260 270 280 290 300
GTDLSDTPED GEARLLVAAR VGTTRLIDNV GVPLGTGFKG LDDGGEGSAP

ADNAGE
Length:306
Mass (Da):32,368
Last modified:August 2, 2005 - v1
Checksum:iA1A86774A8B87F15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI36438.1.
RefSeqiWP_011272998.1. NC_007164.1.
YP_250056.1. NC_007164.1.

Genome annotation databases

EnsemblBacteriaiCAI36438; CAI36438; jk0286.
GeneIDi3432855.
KEGGicjk:jk0286.
PATRICi21511428. VBICorJei31838_0296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI36438.1 .
RefSeqi WP_011272998.1. NC_007164.1.
YP_250056.1. NC_007164.1.

3D structure databases

ProteinModelPortali Q4JXL9.
SMRi Q4JXL9. Positions 2-286.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 306537.jk0286.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI36438 ; CAI36438 ; jk0286 .
GeneIDi 3432855.
KEGGi cjk:jk0286.
PATRICi 21511428. VBICorJei31838_0296.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi PTHFAGM.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci CJEI306537:GJ8V-292-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
    Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
    J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K411.

Entry informationi

Entry nameiPANC_CORJK
AccessioniPrimary (citable) accession number: Q4JXL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: August 2, 2005
Last modified: November 26, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3