Q4JXF5 (Q4JXF5_CORJK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137 RuleBase RU000613
EC=6.3.2.6 HAMAP MF_00137 RuleBase RU000613

Alternative name(s):
SAICAR synthetase HAMAP MF_00137

Gene names

Name:	purC HAMAP MF_00137 EMBL CAI36502.1
Ordered Locus Names:	jk0350

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137 RuleBase RU000613 SAAS SAAS018236
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137 RuleBase RU000613 SAAS SAAS018236
Sequence similarities	Belongs to the SAICAR synthetase family. HAMAP MF_00137 RuleBase RU004193

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00137 RuleBase RU000613 SAAS SAAS018236
Ligand	ATP-binding HAMAP MF_00137 SAAS SAAS018236 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00137 RuleBase RU000613 SAAS SAAS018236 EMBL CAI36502.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4JXF5 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 704591868EACFF42	FASTA	307	34,143
	10 20 30 40 50 60 MPGTGLHCLL MRPELCEYEH HSAGKVREIY EVDEDNLLMV VSDRISAYDY VLDTEIPDKG 70 80 90 100 110 120 RVLTAVSAFF FDEIDFPNHL AGAMDDERIP EYVLGRAMLC KKLDMIPFEC VARGYLTGSG 130 140 150 160 170 180 LKEYQETGSV CGVELPEGLV EASRLPEPIF TPATKAELGD HDENVSFDVV VEALGEERAN 190 200 210 220 230 240 ELREATLSIY KKAAAIAEER GLILADTKFE FGLDADGTLV LADEVLTPDS SRYWPAEGYE 250 260 270 280 290 300 EGKVQPSFDK QYVRNWLTGP KSGWDKSEGT PPPPLPGSVV EATRSRYIEA YEKLSGKRFS DWIGQCV

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K411.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR931997 Genomic DNA. Translation: CAI36502.1.
RefSeq	YP_250120.1. NC_007164.1.
3D structure databases
ProteinModelPortal	Q4JXF5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JXF5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3433000.
GenomeReviews	Gene locus jk0350 in contig CR931997_GR.
KEGG	cjk:jk0350.
NMPDR	fig|306537.3.peg.1361.
PATRIC	21511562. VBICorJei31838_0361.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0152.
HOGENOM	HBG555040.
OMA	LTLMDEV.
ProtClustDB	PRK13961.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q4JXF5_CORJK

Accession

Primary (citable) accession number: Q4JXF5

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)