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Q4JXE7 (Q4JXE7_CORJK) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Name:purF EMBL CAI36510.1
Ordered Locus Names:jk0358
OrganismCorynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]
Taxonomic identifier306537 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site171For GATase activity By similarity PIRSR PIRSR000485-1
Metal binding2571Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4031Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4581Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4611Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

Sequence LengthMass (Da)Tools
Q4JXE7 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: DED5391B917FB441

FASTA49553,197
        10         20         30         40         50         60 
MLSPFDDRGE TEPREECGVF GVWAPGEDVS KLTYYGLYAL QHRGQEAAGI AVGDGDQIVV 

        70         80         90        100        110        120 
FKDLGLVSQV FDEQSLEALK GHIGLGHNRY TTAGGNSWEN AQPMFRMAPD GTDVALGHNG 

       130        140        150        160        170        180 
NLVDHRELTQ EAARLGLVDP KENPSDSLVM CALLAADTRE GHGVEEAAME LFPKVKGAFC 

       190        200        210        220        230        240 
VLFTDGDALY AARDPQGVRP LSIGQLAGGG WVVASETAAL DIVGARFVRD VEPGELVIVD 

       250        260        270        280        290        300 
GDGVRSRRFA ETAHKGCVFE YVYLARPDSV IRGRSVNGAR LQIGRKLAEE APADGDLVIP 

       310        320        330        340        350        360 
VPESGTPAAV GYAQASRIPF GQGLMKNAYV GRTFIQPSQT IRQLGIRLKL NPLREVIEGK 

       370        380        390        400        410        420 
RLVVVDDSIV RGNTQRALIK MLREAGAKEV HVRIASPPVK WPCFYGIDFA SPTELIANNV 

       430        440        450        460        470        480 
DAADPVEGIR KEIDADSLAF VSTEAMIEAS QQSSDELCAA CFDGVFPLGM PSDNPNSALV 

       490 
ETMLKQQAKK ASTKP

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References

[1]"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K411.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR931997 Genomic DNA. Translation: CAI36510.1.
RefSeqYP_250128.1. NC_007164.1.

3D structure databases

ProteinModelPortalQ4JXE7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4JXE7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3433003.
GenomeReviewsGene locus jk0358 in contig CR931997_GR.
KEGGcjk:jk0358.
NMPDRfig|306537.3.peg.1367.
PATRIC21511578. VBICorJei31838_0369.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0034.
HOGENOMHBG392416.
OMAVWAPGEE.
ProtClustDBPRK07847.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR000836. PRibTrfase.
[Graphical view]
KOK00764.
PANTHERPTHR11907. Amd_phspho_trans. 1 hit.
PfamPF00310. GATase_2. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. PurF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ4JXE7_CORJK
AccessionPrimary (citable) accession number: Q4JXE7
Entry history
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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