Reviewed, UniProtKB/Swiss-Prot Q4JXD8 (UPPP1_CORJK)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 1
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 1
    Bacitracin resistance protein 1

Gene names

Name:	uppP1
Ordered Locus Names:	jk0367

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	Undecaprenyl-diphosphatase 1 HAMAP MF_01006		PRO_0000227615
Regions
	Transmembrane	95 – 115	21	Potential
	Transmembrane	119 – 139	21	Potential
	Transmembrane	152 – 172	21	Potential
	Transmembrane	195 – 215	21	Potential
	Transmembrane	227 – 247	21	Potential
	Transmembrane	256 – 276	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4JXD8-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 0CFF3F6080F25A31	FASTA	281	30,422
	10 20 30 40 50 60 MTDPATTMSW VQVIVLSVVQ GLTEFLPVSS SGHLRIVSQL FWGEDAGASF TAVIQLGTEL 70 80 90 100 110 120 AVLVFFAKDI WRILTAWFAG LADKSKRNFD YRMGWMVIAG TIPVGLAGVL LKDLIRENFR 130 140 150 160 170 180 NLWITATVLI LFSLVFILAE RRGKKTRGFE ELTMKDAVLM GLWQCLALIP GVSRSGGTIS 190 200 210 220 230 240 GGLFLNLDRE VATRFSFLLA IPAVLASGLF SLPDAFDPQA GQAASGLQLL VGSGIGFVVG 250 260 270 280 YISIAWLLKF VSNHSFAWFA AYRIPLGLLV MALLGTGVMA A

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR931997 Genomic DNA. Translation: CAI36519.1.
RefSeq	YP_250137.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JXD8.
Genome annotation databases
GeneID	3433526.
GenomeReviews	Gene locus jk0367 in contig CR931997_GR.
KEGG	cjk:jk0367.
NMPDR	fig|306537.3.peg.1468.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HBG391969.
OMA	YEASSIR.
Enzyme and pathway databases
BioCyc	CJEI306537:JK0367-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP1_CORJK

Accession

Primary (citable) accession number: Q4JXD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	August 2, 2005
Last modified:	February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)