Q4JX26 (Q4JX26_CORJK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
NH(3)-dependent NAD(+) synthetase HAMAP MF_00193 RuleBase RU003812
EC=6.3.1.5 HAMAP MF_00193 RuleBase RU003812

Gene names

Name:	nadE HAMAP MF_00193 EMBL CAI36631.1
Ordered Locus Names:	jk0474

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. HAMAP MF_00193 RuleBase RU003812 SAAS SAAS003694
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. HAMAP MF_00193 SAAS SAAS003694 RuleBase RU004252
Sequence similarities	Belongs to the NAD synthetase family. HAMAP MF_00193 RuleBase RU003811

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_00193 SAAS SAAS003694 RuleBase RU003811 NAD HAMAP MF_00193 SAAS SAAS003694 RuleBase RU003811 Nucleotide-binding
Molecular function	Ligase SAAS SAAS003694 HAMAP MF_00193 RuleBase RU003811 EMBL CAI36631.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP NAD+ synthase (glutamine-hydrolyzing) activity Inferred from electronic annotation. Source: InterPro NAD+ synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	71 – 78	8	ATP By similarity HAMAP MF_00193
Sites
	Active site	73	1	By similarity HAMAP MF_00193

Sequences

	Sequence		Length	Mass (Da)
	Q4JX26 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 4EA162A42312D0F3	FASTA	316	34,045
	10 20 30 40 50 60 MSPTANQPNG TPDTPDKPGT SNESNARPLH AQIVAELGVR PSIDPAKEVK RRVQFIADYM 70 80 90 100 110 120 QATGVHALVL GISGGQDSTL AGRLCQLAVD RLNQENAQAE QSVQENTSHP YTFCAVRLPY 130 140 150 160 170 180 GTQADEEDAQ IALRFIAPSM GVTVNIKGAT DESARATSEA LGIAQVSDFN KGNIKARERM 190 200 210 220 230 240 IAQYALAGEL GGLVVGTDHA AEAITGFYTK HGDGAADLVP LAGLTKRQGA ALLQHLGAPE 250 260 270 280 290 300 STWQKVPTAD LEEDRPALPD EEALGVTYAQ LDDYLESTNG AADIDPTVAE HIEKLWFRSR 310 HKRHLPVTPH DDWWRS

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K411.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR931997 Genomic DNA. Translation: CAI36631.1.
RefSeq	YP_250249.1. NC_007164.1.
3D structure databases
ProteinModelPortal	Q4JX26.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JX26.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3432786.
GenomeReviews	Gene locus jk0474 in contig CR931997_GR.
KEGG	cjk:jk0474.
NMPDR	fig|306537.3.peg.2022.
PATRIC	21511832. VBICorJei31838_0486.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0171.
HOGENOM	HBG351567.
OMA	IAQYEIA.
ProtClustDB	PRK00768.
Family and domain databases
HAMAP	MF_00193. NadE. [Tree]
InterPro	IPR022310. NAD/GMP_synthase. IPR003694. NAD_synthase. IPR022926. NH(3)-dep_NAD(+)_synth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01916.
Pfam	PF02540. NAD_synthase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00552. NadE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q4JX26_CORJK

Accession

Primary (citable) accession number: Q4JX26

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)