Q4JWA8 (Q4JWA8_CORJK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Name:	metF EMBL CAI36899.1
Ordered Locus Names:	jk0737

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862 EMBL CAI36899.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4JWA8 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: D757708CF3FBD6AA	FASTA	322	35,494
	10 20 30 40 50 60 MASIRRQVAV SQSLSLNTPG RVPFSVEFMP PRDDAAEERL WNAAEAFHDL GVSFASVTYG 70 80 90 100 110 120 AGGSTRERTL RVAERLGTKP LTTLVHMTLV QHTQEELQDM LRTYASLGLT NLLALRGDPP 130 140 150 160 170 180 GDPNAEWVPT PGGLSYASEL IELIREMPEC ADFDIGIASF PEGHYRTGSL EQDTEYTLAK 190 200 210 220 230 240 LRAGAQYSIT QMFFDVDHYL RLRDRLAKAD PEHGQKPIIP GLMPITSLRS VRRQMELAGA 250 260 270 280 290 300 ALPPKLEKRL LDAAAGDEVA NRDAIREVGI EVTTEMAERL IAEGVPDLHF MTMNNVRATQ 310 320 EVLHNLGMAP AWGPGLGHDM VR

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K411.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR931997 Genomic DNA. Translation: CAI36899.1.
RefSeq	YP_250517.1. NC_007164.1.
3D structure databases
ProteinModelPortal	Q4JWA8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JWA8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3433305.
GenomeReviews	Gene locus jk0737 in contig CR931997_GR.
KEGG	cjk:jk0737.
NMPDR	fig|306537.3.peg.1509.
PATRIC	21512366. VBICorJei31838_0745.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0685.
HOGENOM	HBG649727.
OMA	ITQMFFD.
ProtClustDB	CLSK638719.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q4JWA8_CORJK

Accession

Primary (citable) accession number: Q4JWA8

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)