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Q4JW97 (MURD_CORJK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
EC=6.3.2.9
Alternative name(s):
D-glutamic acid-adding enzyme
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Gene names
Name:murD
Ordered Locus Names:jk0748
OrganismCorynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]
Taxonomic identifier306537 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639

Subcellular location

Cytoplasm By similarity HAMAP MF_00639.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639
PRO_0000109005

Regions

Nucleotide binding136 – 1427ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q4JW97 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: B5826331543E1317

FASTA50251,982
        10         20         30         40         50         60 
MESTHALQPA EALETMRSQT VLVAGAGVAG RGVISMLCAL GARLVLVADD NAQALGHIAD 

        70         80         90        100        110        120 
DGDTELRLLS VSDAIDTLEE LAPQLVVTSP GWKPESPLLA RAAELNIPVI GDIAAAWLAD 

       130        140        150        160        170        180 
QAGAFGQPRT WLAVTGTNGK TTTTAMLTSM LIADGRAALA VGNIGIAPSA ALAAQHRGEP 

       190        200        210        220        230        240 
RSDVFVAEVS SFQLHWAPMF KPTVGCILNL AEDHLDWHGS YENYCADKAQ VLTAEESVLA 

       250        260        270        280        290        300 
LDDDDVLTTA RAREVVARRG YTIHDPEEVA SQNTERVVGV RDGRLVEVVI GDPSQTTDLA 

       310        320        330        340        350        360 
PAQGISPPGP AGLADAAASA AMARALGVAP GAIEAALAGF KVQAHRGQVV LEHGGVTWID 

       370        380        390        400        410        420 
NSKATNPHAA EAALRGQRNV IWVAGGQLKG AAVDGLIRAI GGALKAVVAL GVDRAELVAE 

       430        440        450        460        470        480 
VSRQLPDLPV TVIDATDPEE AMRAVARAAH GLAQPGDSVV LAPAAASLDM YTGMSQRGDL 

       490        500 
FAQYAVAYAG ADRADERTQE RG

« Hide

References

[1]"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K411.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR931997 Genomic DNA. Translation: CAI36910.1.
RefSeqYP_250528.1. NC_007164.1.

3D structure databases

ProteinModelPortalQ4JW97.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4JW97.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3432774.
GenomeReviewsGene locus jk0748 in contig CR931997_GR.
KEGGcjk:jk0748.
NMPDRfig|306537.3.peg.1607.
PATRIC21512388. VBICorJei31838_0756.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0771.
HOGENOMHBG750024.
OMAACASWDM.
ProtClustDBPRK00141.

Enzyme and pathway databases

BioCycCJEI306537:JK0748-MONOMER.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01925.
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. MurD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURD_CORJK
AccessionPrimary (citable) accession number: Q4JW97
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: August 2, 2005
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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