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Q4JW59

- HISX_CORJK

UniProt

Q4JW59 - HISX_CORJK

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Protein
Histidinol dehydrogenase
Gene
hisD, jk0786
Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351NAD By similarity
Binding sitei197 – 1971NAD By similarity
Binding sitei225 – 2251NAD By similarity
Binding sitei248 – 2481Substrate By similarity
Metal bindingi270 – 2701Zinc By similarity
Binding sitei270 – 2701Substrate By similarity
Metal bindingi273 – 2731Zinc By similarity
Binding sitei273 – 2731Substrate By similarity
Active sitei339 – 3391Proton acceptor By similarity
Active sitei340 – 3401Proton acceptor By similarity
Binding sitei340 – 3401Substrate By similarity
Metal bindingi373 – 3731Zinc By similarity
Binding sitei373 – 3731Substrate By similarity
Binding sitei427 – 4271Substrate By similarity
Metal bindingi432 – 4321Zinc By similarity
Binding sitei432 – 4321Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciCJEI306537:GJ8V-815-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:jk0786
OrganismiCorynebacterium jeikeium (strain K411)
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000545: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Histidinol dehydrogenaseUniRule annotation
PRO_0000135762Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi306537.jk0786.

Structurei

3D structure databases

ProteinModelPortaliQ4JW59.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiDEMAMPI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4JW59-1 [UniParc]FASTAAdd to Basket

« Hide

MTSAQLDFSR IDLRGQAPTT AELRHRLPRG GTDVDSVIPT VAPIVDQVRE    50
GGARAALEIG QRFDGVTPDS VRVPAEVIDA AVGTLADDVI AALEEAIKRV 100
RAFHSAIRPE DKQVEVAPGG IVTERFIPVQ RVGLYAPGGN AVYPSSVIMN 150
VVPAQEAGVE SLVVASPPQE GGWPHPTVLA ACKLLGVDEV WAVGGAQAVA 200
LLAHGSTAEG GEELEPVDMV TGPGNIFVTA AKRLCRSVVG IDSEAGPTEI 250
AVLADESANA VEIAYDLISQ AEHDTMAASV LITDSEKLAD EVVAEMNERY 300
HITENSERVA EALSGQQSGV VLVDDIAAGI RAANAYGAEH LEIHTEDAHG 350
VAAQITNAGA IFIGRFSPVP LGDYAAGSNH VLPTSGTARH SSGLSTLTFL 400
KSVHVIDYNE EGLRGVADTV ITLSKSEGLP AHGEAISART STANTNGTEV 450
Length:450
Mass (Da):46,775
Last modified:August 2, 2005 - v1
Checksum:i2BED7B5FA2E531C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR931997 Genomic DNA. Translation: CAI36948.1.
RefSeqiWP_011273391.1. NC_007164.1.
YP_250566.1. NC_007164.1.

Genome annotation databases

EnsemblBacteriaiCAI36948; CAI36948; jk0786.
GeneIDi3433179.
KEGGicjk:jk0786.
PATRICi21512466. VBICorJei31838_0795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR931997 Genomic DNA. Translation: CAI36948.1 .
RefSeqi WP_011273391.1. NC_007164.1.
YP_250566.1. NC_007164.1.

3D structure databases

ProteinModelPortali Q4JW59.
ModBasei Search...

Protein-protein interaction databases

STRINGi 306537.jk0786.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI36948 ; CAI36948 ; jk0786 .
GeneIDi 3433179.
KEGGi cjk:jk0786.
PATRICi 21512466. VBICorJei31838_0795.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi DEMAMPI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci CJEI306537:GJ8V-815-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
    Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
    J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K411.

Entry informationi

Entry nameiHISX_CORJK
AccessioniPrimary (citable) accession number: Q4JW59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 2, 2005
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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