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Q4JW59 (HISX_CORJK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:jk0786
OrganismCorynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]
Taxonomic identifier306537 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135762

Sites

Active site3391Proton acceptor By similarity
Active site3401Proton acceptor By similarity
Metal binding2701Zinc By similarity
Metal binding2731Zinc By similarity
Metal binding3731Zinc By similarity
Metal binding4321Zinc By similarity
Binding site1351NAD By similarity
Binding site1971NAD By similarity
Binding site2251NAD By similarity
Binding site2481Substrate By similarity
Binding site2701Substrate By similarity
Binding site2731Substrate By similarity
Binding site3401Substrate By similarity
Binding site3731Substrate By similarity
Binding site4271Substrate By similarity
Binding site4321Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4JW59 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 2BED7B5FA2E531C5

FASTA45046,775
        10         20         30         40         50         60 
MTSAQLDFSR IDLRGQAPTT AELRHRLPRG GTDVDSVIPT VAPIVDQVRE GGARAALEIG 

        70         80         90        100        110        120 
QRFDGVTPDS VRVPAEVIDA AVGTLADDVI AALEEAIKRV RAFHSAIRPE DKQVEVAPGG 

       130        140        150        160        170        180 
IVTERFIPVQ RVGLYAPGGN AVYPSSVIMN VVPAQEAGVE SLVVASPPQE GGWPHPTVLA 

       190        200        210        220        230        240 
ACKLLGVDEV WAVGGAQAVA LLAHGSTAEG GEELEPVDMV TGPGNIFVTA AKRLCRSVVG 

       250        260        270        280        290        300 
IDSEAGPTEI AVLADESANA VEIAYDLISQ AEHDTMAASV LITDSEKLAD EVVAEMNERY 

       310        320        330        340        350        360 
HITENSERVA EALSGQQSGV VLVDDIAAGI RAANAYGAEH LEIHTEDAHG VAAQITNAGA 

       370        380        390        400        410        420 
IFIGRFSPVP LGDYAAGSNH VLPTSGTARH SSGLSTLTFL KSVHVIDYNE EGLRGVADTV 

       430        440        450 
ITLSKSEGLP AHGEAISART STANTNGTEV 

« Hide

References

[1]"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K411.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR931997 Genomic DNA. Translation: CAI36948.1.
RefSeqYP_250566.1. NC_007164.1.

3D structure databases

ProteinModelPortalQ4JW59.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING306537.jk0786.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI36948; CAI36948; jk0786.
GeneID3433179.
KEGGcjk:jk0786.
PATRIC21512466. VBICorJei31838_0795.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMADEMAMPI.
OrthoDBEOG6CVVCR.

Enzyme and pathway databases

BioCycCJEI306537:GJ8V-815-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_CORJK
AccessionPrimary (citable) accession number: Q4JW59
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways