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Q4JW59

- HISX_CORJK

UniProt

Q4JW59 - HISX_CORJK

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei135 – 1351NADUniRule annotation
    Binding sitei197 – 1971NADUniRule annotation
    Binding sitei225 – 2251NADUniRule annotation
    Binding sitei248 – 2481SubstrateUniRule annotation
    Metal bindingi270 – 2701ZincUniRule annotation
    Binding sitei270 – 2701SubstrateUniRule annotation
    Metal bindingi273 – 2731ZincUniRule annotation
    Binding sitei273 – 2731SubstrateUniRule annotation
    Active sitei339 – 3391Proton acceptorUniRule annotation
    Active sitei340 – 3401Proton acceptorUniRule annotation
    Binding sitei340 – 3401SubstrateUniRule annotation
    Metal bindingi373 – 3731ZincUniRule annotation
    Binding sitei373 – 3731SubstrateUniRule annotation
    Binding sitei427 – 4271SubstrateUniRule annotation
    Metal bindingi432 – 4321ZincUniRule annotation
    Binding sitei432 – 4321SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciCJEI306537:GJ8V-815-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:jk0786
    OrganismiCorynebacterium jeikeium (strain K411)
    Taxonomic identifieri306537 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000545: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Histidinol dehydrogenasePRO_0000135762Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi306537.jk0786.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4JW59.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiDEMAMPI.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4JW59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSAQLDFSR IDLRGQAPTT AELRHRLPRG GTDVDSVIPT VAPIVDQVRE    50
    GGARAALEIG QRFDGVTPDS VRVPAEVIDA AVGTLADDVI AALEEAIKRV 100
    RAFHSAIRPE DKQVEVAPGG IVTERFIPVQ RVGLYAPGGN AVYPSSVIMN 150
    VVPAQEAGVE SLVVASPPQE GGWPHPTVLA ACKLLGVDEV WAVGGAQAVA 200
    LLAHGSTAEG GEELEPVDMV TGPGNIFVTA AKRLCRSVVG IDSEAGPTEI 250
    AVLADESANA VEIAYDLISQ AEHDTMAASV LITDSEKLAD EVVAEMNERY 300
    HITENSERVA EALSGQQSGV VLVDDIAAGI RAANAYGAEH LEIHTEDAHG 350
    VAAQITNAGA IFIGRFSPVP LGDYAAGSNH VLPTSGTARH SSGLSTLTFL 400
    KSVHVIDYNE EGLRGVADTV ITLSKSEGLP AHGEAISART STANTNGTEV 450
    Length:450
    Mass (Da):46,775
    Last modified:August 2, 2005 - v1
    Checksum:i2BED7B5FA2E531C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR931997 Genomic DNA. Translation: CAI36948.1.
    RefSeqiWP_011273391.1. NC_007164.1.
    YP_250566.1. NC_007164.1.

    Genome annotation databases

    EnsemblBacteriaiCAI36948; CAI36948; jk0786.
    GeneIDi3433179.
    KEGGicjk:jk0786.
    PATRICi21512466. VBICorJei31838_0795.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR931997 Genomic DNA. Translation: CAI36948.1 .
    RefSeqi WP_011273391.1. NC_007164.1.
    YP_250566.1. NC_007164.1.

    3D structure databases

    ProteinModelPortali Q4JW59.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 306537.jk0786.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI36948 ; CAI36948 ; jk0786 .
    GeneIDi 3433179.
    KEGGi cjk:jk0786.
    PATRICi 21512466. VBICorJei31838_0795.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi DEMAMPI.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci CJEI306537:GJ8V-815-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
      Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
      J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K411.

    Entry informationi

    Entry nameiHISX_CORJK
    AccessioniPrimary (citable) accession number: Q4JW59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3