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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351NADUniRule annotation
Binding sitei197 – 1971NADUniRule annotation
Binding sitei225 – 2251NADUniRule annotation
Binding sitei248 – 2481SubstrateUniRule annotation
Metal bindingi270 – 2701ZincUniRule annotation
Binding sitei270 – 2701SubstrateUniRule annotation
Metal bindingi273 – 2731ZincUniRule annotation
Binding sitei273 – 2731SubstrateUniRule annotation
Active sitei339 – 3391Proton acceptorUniRule annotation
Active sitei340 – 3401Proton acceptorUniRule annotation
Binding sitei340 – 3401SubstrateUniRule annotation
Metal bindingi373 – 3731ZincUniRule annotation
Binding sitei373 – 3731SubstrateUniRule annotation
Binding sitei427 – 4271SubstrateUniRule annotation
Metal bindingi432 – 4321ZincUniRule annotation
Binding sitei432 – 4321SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciCJEI306537:GJ8V-815-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:jk0786
OrganismiCorynebacterium jeikeium (strain K411)
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000545: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Histidinol dehydrogenasePRO_0000135762Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi306537.jk0786.

Structurei

3D structure databases

ProteinModelPortaliQ4JW59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4JW59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSAQLDFSR IDLRGQAPTT AELRHRLPRG GTDVDSVIPT VAPIVDQVRE
60 70 80 90 100
GGARAALEIG QRFDGVTPDS VRVPAEVIDA AVGTLADDVI AALEEAIKRV
110 120 130 140 150
RAFHSAIRPE DKQVEVAPGG IVTERFIPVQ RVGLYAPGGN AVYPSSVIMN
160 170 180 190 200
VVPAQEAGVE SLVVASPPQE GGWPHPTVLA ACKLLGVDEV WAVGGAQAVA
210 220 230 240 250
LLAHGSTAEG GEELEPVDMV TGPGNIFVTA AKRLCRSVVG IDSEAGPTEI
260 270 280 290 300
AVLADESANA VEIAYDLISQ AEHDTMAASV LITDSEKLAD EVVAEMNERY
310 320 330 340 350
HITENSERVA EALSGQQSGV VLVDDIAAGI RAANAYGAEH LEIHTEDAHG
360 370 380 390 400
VAAQITNAGA IFIGRFSPVP LGDYAAGSNH VLPTSGTARH SSGLSTLTFL
410 420 430 440 450
KSVHVIDYNE EGLRGVADTV ITLSKSEGLP AHGEAISART STANTNGTEV
Length:450
Mass (Da):46,775
Last modified:August 2, 2005 - v1
Checksum:i2BED7B5FA2E531C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI36948.1.
RefSeqiYP_250566.1. NC_007164.1.

Genome annotation databases

EnsemblBacteriaiCAI36948; CAI36948; jk0786.
GeneIDi3433179.
KEGGicjk:jk0786.
PATRICi21512466. VBICorJei31838_0795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI36948.1.
RefSeqiYP_250566.1. NC_007164.1.

3D structure databases

ProteinModelPortaliQ4JW59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi306537.jk0786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI36948; CAI36948; jk0786.
GeneIDi3433179.
KEGGicjk:jk0786.
PATRICi21512466. VBICorJei31838_0795.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciCJEI306537:GJ8V-815-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
    Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
    J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K411.

Entry informationi

Entry nameiHISX_CORJK
AccessioniPrimary (citable) accession number: Q4JW59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 2, 2005
Last modified: February 4, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.