Reviewed, UniProtKB/Swiss-Prot Q4JW20 (COAE_CORJK)

Names and origin

Protein names

Recommended name:
    Dephospho-CoA kinase
    EC=2.7.1.24
Alternative name(s):
    Dephosphocoenzyme A kinase

Gene names

Name:	coaE
Ordered Locus Names:	jk0825

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity.
Catalytic activity	ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP MF_00376
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme A from pantothenate: step 5/5. HAMAP MF_00376
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the coaE family. Contains 1 DPCK (dephospho-CoA kinase) domain.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP dephospho-CoA kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	Dephospho-CoA kinase HAMAP MF_00376		PRO_0000243278
Regions
	Domain	3 – 194	192	DPCK
	Nucleotide binding	8 – 15	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4JW20-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 6C63EFEA7F9616CA	FASTA	194	20,974
	10 20 30 40 50 60 MITIGLTGGI GSGKSTVSSR LAELGAFIVD ADLVAREIVE PGQPALAELA DAFDGVLNPD 70 80 90 100 110 120 GTLNRGELAR QAFATPEATE KLNAITHPRI RARTEELFKQ GRESGAQVLV YDMPLLIENG 130 140 150 160 170 180 EVDKVDHVLV VDAPDELRID RLVQHRGLDE NDARRRIAAQ IDRATRLNAA DTVLDNSGTV 190 EQLLEQVDGF WGGL

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR931997 Genomic DNA. Translation: CAI36987.1.
RefSeq	YP_250605.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3432190.
GenomeReviews	Gene locus jk0825 in contig CR931997_GR.
KEGG	cjk:jk0825.
NMPDR	fig|306537.3.peg.1913.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4JW20.
OMA	Q4JW20. LHPMIRQ.
Enzyme and pathway databases
BioCyc	CJEI306537:JK0825-MON.
Family and domain databases
HAMAP	MF_00376. [Tree]
InterPro	IPR001977. Depp_CoAkinase. [Graphical view]
PANTHER	PTHR10695. Depp_CoAkinase. 1 hit.
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
ProDom	PD003329. Depp_CoAkinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00152. Depp_CoAkinase. 1 hit.
PROSITE	PS51219. DPCK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COAE_CORJK

Accession

Primary (citable) accession number: Q4JW20

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	August 2, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)