Q4JW04 (Q4JW04_CORJK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150
Short name=AGPR HAMAP MF_00150
EC=1.2.1.38 HAMAP MF_00150

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase HAMAP MF_00150

Gene names

Name:	argC HAMAP MF_00150 EMBL CAI37003.1
Ordered Locus Names:	jk0841

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150 SAAS SAAS023013
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate. RuleBase RU004258 Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150 SAAS SAAS023013
Subcellular location	Cytoplasm By similarity HAMAP MF_00150 SAAS SAAS023013.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. HAMAP MF_00150

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis HAMAP MF_00150 SAAS SAAS023013
Cellular component	Cytoplasm HAMAP MF_00150 SAAS SAAS023013
Ligand	NADP HAMAP MF_00150 SAAS SAAS023013
Molecular function	Oxidoreductase HAMAP MF_00150 SAAS SAAS023013 EMBL CAI37003.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	147	1	By similarity HAMAP MF_00150

Sequences

	Sequence		Length	Mass (Da)
	Q4JW04 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 741B181B18251A8C	FASTA	341	35,664
	10 20 30 40 50 60 MLKIAVAGAS GYAGGEALRL LLNHPGYGVD FEIGSLTGGS NAGTRFGELN PGLPALADRV 70 80 90 100 110 120 LEETTEDVLR GHDAAILALP HGVSAALDLP ESMKIVDCGA DYRLKNANHW ARFYGTPHAG 130 140 150 160 170 180 TRTYGIPEMP GRREEIAATN YVAAPGCFPT GATMALMPAI ASGLMAPQIS VVSVTGTTGA 190 200 210 220 230 240 GKKAAVNLLG SETMGNLRAY GVGTHRHAPE IKQSVEELLA PGYSSDDVHV TFTPVLAPLT 250 260 270 280 290 300 RGILTTVTAP ARGQARDIRR AYEKFCANEP FLHLLPEGQQ PEVKSVVGSN MVHIQVEVAD 310 320 330 340 GMVIATSAID NLTKGTAGAA IQCLNLMFGW EENAGLPQTG L

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K411.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR931997 Genomic DNA. Translation: CAI37003.1.
RefSeq	YP_250621.1. NC_007164.1.
3D structure databases
ProteinModelPortal	Q4JW04.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JW04.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3432213.
GenomeReviews	Gene locus jk0841 in contig CR931997_GR.
KEGG	cjk:jk0841.
NMPDR	fig|306537.3.peg.2033.
PATRIC	21512582. VBICorJei31838_0852.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	SHFSWRN.
ProtClustDB	CLSK2309244.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q4JW04_CORJK

Accession

Primary (citable) accession number: Q4JW04

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)