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Q4JVX8 (NADK_CORJK) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:jk0865
OrganismCorynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]
Taxonomic identifier306537 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329NAD kinase HAMAP-Rule MF_00361
PRO_0000229628

Regions

Nucleotide binding104 – 1052NAD By similarity
Nucleotide binding179 – 1802NAD By similarity
Nucleotide binding220 – 2256NAD By similarity

Sites

Active site1041Proton acceptor By similarity
Binding site1091NAD By similarity
Binding site2091NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4JVX8 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 1BCA8AFCCC1A1242

FASTA32935,390
        10         20         30         40         50         60 
MTTPGTDHNA DQGADSGDKA TKAASGAQTE REVLLVAHTG VHENLGLAAE AASRLQKGGI 

        70         80         90        100        110        120 
NVRVMATADP APVARHEVLG RFKRFGHTKE AATGVEMVIV LGGDGTFLRA ADIAHSADVP 

       130        140        150        160        170        180 
VLGINMGHIG FLAEWEQESL QEAVDRVIDR DYRIEDRMTL SITARDMDGR VLGTGWALNE 

       190        200        210        220        230        240 
CSVENLNRQG VLDTILEVDE RPVSSFGCDG VLVSTPTGST AYAFSAGGPV LWPELDAILV 

       250        260        270        280        290        300 
VTSNAHTLFS RPLVVSPNSM VAVETNPSTS PATVVMDGFR QIHMPPGARV EIRRGPQPVR 

       310        320 
WVRLDSAPFT DRLVHKFRLP VTGWRGPRH 

« Hide

References

[1]"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K411.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR931997 Genomic DNA. Translation: CAI37029.1.
RefSeqYP_250647.1. NC_007164.1.

3D structure databases

ProteinModelPortalQ4JVX8.
SMRQ4JVX8. Positions 30-326.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING306537.jk0865.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI37029; CAI37029; jk0865.
GeneID3432972.
KEGGcjk:jk0865.
PATRIC21512640. VBICorJei31838_0878.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227223.
KOK00858.
OMAGVLWCDG.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycCJEI306537:GJ8V-898-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_CORJK
AccessionPrimary (citable) accession number: Q4JVX8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 2, 2005
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families