ID   FTHS_CORJK              Reviewed;         562 AA.
AC   Q4JVW2;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   27-MAR-2024, entry version 98.
DE   RecName: Full=Formate--tetrahydrofolate ligase {ECO:0000255|HAMAP-Rule:MF_01543};
DE            EC=6.3.4.3 {ECO:0000255|HAMAP-Rule:MF_01543};
DE   AltName: Full=Formyltetrahydrofolate synthetase {ECO:0000255|HAMAP-Rule:MF_01543};
DE            Short=FHS {ECO:0000255|HAMAP-Rule:MF_01543};
DE            Short=FTHFS {ECO:0000255|HAMAP-Rule:MF_01543};
GN   Name=fhs {ECO:0000255|HAMAP-Rule:MF_01543}; OrderedLocusNames=jk0881;
OS   Corynebacterium jeikeium (strain K411).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC   Corynebacteriaceae; Corynebacterium.
OX   NCBI_TaxID=306537;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K411;
RX   PubMed=15968079; DOI=10.1128/jb.187.13.4671-4682.2005;
RA   Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A.,
RA   Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F.,
RA   Rupp O., Schneiker S., Viehoever P., Puehler A.;
RT   "Complete genome sequence and analysis of the multiresistant nosocomial
RT   pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the
RT   human skin flora.";
RL   J. Bacteriol. 187:4671-4682(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10-
CC         formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57453, ChEBI:CHEBI:195366, ChEBI:CHEBI:456216;
CC         EC=6.3.4.3; Evidence={ECO:0000255|HAMAP-Rule:MF_01543};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000255|HAMAP-Rule:MF_01543}.
CC   -!- SIMILARITY: Belongs to the formate--tetrahydrofolate ligase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01543}.
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DR   EMBL; CR931997; CAI37045.1; -; Genomic_DNA.
DR   RefSeq; WP_011273471.1; NC_007164.1.
DR   AlphaFoldDB; Q4JVW2; -.
DR   SMR; Q4JVW2; -.
DR   STRING; 306537.jk0881; -.
DR   GeneID; 3432566; -.
DR   KEGG; cjk:jk0881; -.
DR   PATRIC; fig|306537.10.peg.893; -.
DR   eggNOG; COG2759; Bacteria.
DR   HOGENOM; CLU_003601_3_3_11; -.
DR   OrthoDB; 9761733at2; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000000545; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00477; FTHFS; 1.
DR   Gene3D; 3.30.1510.10; Domain 2, N(10)-formyltetrahydrofolate synthetase; 1.
DR   Gene3D; 3.10.410.10; Formyltetrahydrofolate synthetase, domain 3; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_01543; FTHFS; 1.
DR   InterPro; IPR000559; Formate_THF_ligase.
DR   InterPro; IPR020628; Formate_THF_ligase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01268; FTHFS; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00721; FTHFS_1; 1.
DR   PROSITE; PS00722; FTHFS_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding; One-carbon metabolism;
KW   Reference proteome.
FT   CHAIN           1..562
FT                   /note="Formate--tetrahydrofolate ligase"
FT                   /id="PRO_0000199343"
FT   BINDING         77..84
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01543"
SQ   SEQUENCE   562 AA;  58634 MW;  7CF7496392C041F4 CRC64;
     MTNSSATSNP QPSDVEIAQA HTLEPITTIA ERAGIPEAAL IPYGRTKAKI DVPALRAERE
     GVNKKGKLVL VTAMSPTPAG EGKSTVLIGL ADAVRTAGRQ TMVAIREPSQ GPVMGIKGGA
     AGGGYAQIVP MEDINLHFTG DMHAITAATN TLAAMVDNHV QHGNALGIDP RRVTWRRCLD
     VNDRSLRHVV TGLGGPGQGT PREGGFDITA ASEIMAILCL ATDLEDLKKR IGRIVVGQTY
     DRRPVTAGDL KCAGAITALL RDAINPNLVQ TLGGTPALVH GGPFANIAHG CNSLIATTTA
     LDLSEVVLTE AGFGSDLGAE KFFDIKSRAG DLDVAATVVV ATIRSLKHNG DSVLKAGLAN
     LERHVSNIRK FGVEPVVALN LFSSDTAAER SMVADWGEQF GVRVVECSVW AEGGAGAADL
     ATAVLEVVDG VSDEDASSSS HQIYQPVDGV EATLHTLATE IYGAADVQFG PQALKDLAFL
     KDNGWDKLPV CVSKTQYSFS DDPSALGAPS GHTLHVRELV PRIGAGFVVA LTGDVMTLPG
     LPKKPAAERI DVNAQGVISG LF
//