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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi77 – 84ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:jk0881
OrganismiCorynebacterium jeikeium (strain K411)
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000545 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001993431 – 562Formate--tetrahydrofolate ligaseAdd BLAST562

Interactioni

Protein-protein interaction databases

STRINGi306537.jk0881.

Structurei

3D structure databases

ProteinModelPortaliQ4JVW2.
SMRiQ4JVW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiPOG091H01S8.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiView protein in InterPro
IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01268. FTHFS. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4JVW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSSATSNP QPSDVEIAQA HTLEPITTIA ERAGIPEAAL IPYGRTKAKI
60 70 80 90 100
DVPALRAERE GVNKKGKLVL VTAMSPTPAG EGKSTVLIGL ADAVRTAGRQ
110 120 130 140 150
TMVAIREPSQ GPVMGIKGGA AGGGYAQIVP MEDINLHFTG DMHAITAATN
160 170 180 190 200
TLAAMVDNHV QHGNALGIDP RRVTWRRCLD VNDRSLRHVV TGLGGPGQGT
210 220 230 240 250
PREGGFDITA ASEIMAILCL ATDLEDLKKR IGRIVVGQTY DRRPVTAGDL
260 270 280 290 300
KCAGAITALL RDAINPNLVQ TLGGTPALVH GGPFANIAHG CNSLIATTTA
310 320 330 340 350
LDLSEVVLTE AGFGSDLGAE KFFDIKSRAG DLDVAATVVV ATIRSLKHNG
360 370 380 390 400
DSVLKAGLAN LERHVSNIRK FGVEPVVALN LFSSDTAAER SMVADWGEQF
410 420 430 440 450
GVRVVECSVW AEGGAGAADL ATAVLEVVDG VSDEDASSSS HQIYQPVDGV
460 470 480 490 500
EATLHTLATE IYGAADVQFG PQALKDLAFL KDNGWDKLPV CVSKTQYSFS
510 520 530 540 550
DDPSALGAPS GHTLHVRELV PRIGAGFVVA LTGDVMTLPG LPKKPAAERI
560
DVNAQGVISG LF
Length:562
Mass (Da):58,634
Last modified:August 2, 2005 - v1
Checksum:i7CF7496392C041F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI37045.1.
RefSeqiWP_011273471.1. NC_007164.1.

Genome annotation databases

EnsemblBacteriaiCAI37045; CAI37045; jk0881.
GeneIDi3432566.
KEGGicjk:jk0881.
PATRICifig|306537.10.peg.893.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFTHS_CORJK
AccessioniPrimary (citable) accession number: Q4JVW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 2, 2005
Last modified: July 5, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families