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Q4JVW2 (FTHS_CORJK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:jk0881
OrganismCorynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]
Taxonomic identifier306537 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 562562Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199343

Regions

Nucleotide binding77 – 848ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4JVW2 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 7CF7496392C041F4

FASTA56258,634
        10         20         30         40         50         60 
MTNSSATSNP QPSDVEIAQA HTLEPITTIA ERAGIPEAAL IPYGRTKAKI DVPALRAERE 

        70         80         90        100        110        120 
GVNKKGKLVL VTAMSPTPAG EGKSTVLIGL ADAVRTAGRQ TMVAIREPSQ GPVMGIKGGA 

       130        140        150        160        170        180 
AGGGYAQIVP MEDINLHFTG DMHAITAATN TLAAMVDNHV QHGNALGIDP RRVTWRRCLD 

       190        200        210        220        230        240 
VNDRSLRHVV TGLGGPGQGT PREGGFDITA ASEIMAILCL ATDLEDLKKR IGRIVVGQTY 

       250        260        270        280        290        300 
DRRPVTAGDL KCAGAITALL RDAINPNLVQ TLGGTPALVH GGPFANIAHG CNSLIATTTA 

       310        320        330        340        350        360 
LDLSEVVLTE AGFGSDLGAE KFFDIKSRAG DLDVAATVVV ATIRSLKHNG DSVLKAGLAN 

       370        380        390        400        410        420 
LERHVSNIRK FGVEPVVALN LFSSDTAAER SMVADWGEQF GVRVVECSVW AEGGAGAADL 

       430        440        450        460        470        480 
ATAVLEVVDG VSDEDASSSS HQIYQPVDGV EATLHTLATE IYGAADVQFG PQALKDLAFL 

       490        500        510        520        530        540 
KDNGWDKLPV CVSKTQYSFS DDPSALGAPS GHTLHVRELV PRIGAGFVVA LTGDVMTLPG 

       550        560 
LPKKPAAERI DVNAQGVISG LF 

« Hide

References

[1]"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K411.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR931997 Genomic DNA. Translation: CAI37045.1.
RefSeqYP_250663.1. NC_007164.1.

3D structure databases

ProteinModelPortalQ4JVW2.
SMRQ4JVW2. Positions 14-560.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING306537.jk0881.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI37045; CAI37045; jk0881.
GeneID3432566.
KEGGcjk:jk0881.
PATRIC21512670. VBICorJei31838_0893.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycCJEI306537:GJ8V-914-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_CORJK
AccessionPrimary (citable) accession number: Q4JVW2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 2, 2005
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways