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Q4JVW2

- FTHS_CORJK

UniProt

Q4JVW2 - FTHS_CORJK

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi77 – 848ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEI306537:GJ8V-914-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:jk0881
OrganismiCorynebacterium jeikeium (strain K411)
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000545: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Formate--tetrahydrofolate ligasePRO_0000199343Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi306537.jk0881.

Structurei

3D structure databases

ProteinModelPortaliQ4JVW2.
SMRiQ4JVW2. Positions 14-560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiTWRRCLD.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4JVW2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNSSATSNP QPSDVEIAQA HTLEPITTIA ERAGIPEAAL IPYGRTKAKI
60 70 80 90 100
DVPALRAERE GVNKKGKLVL VTAMSPTPAG EGKSTVLIGL ADAVRTAGRQ
110 120 130 140 150
TMVAIREPSQ GPVMGIKGGA AGGGYAQIVP MEDINLHFTG DMHAITAATN
160 170 180 190 200
TLAAMVDNHV QHGNALGIDP RRVTWRRCLD VNDRSLRHVV TGLGGPGQGT
210 220 230 240 250
PREGGFDITA ASEIMAILCL ATDLEDLKKR IGRIVVGQTY DRRPVTAGDL
260 270 280 290 300
KCAGAITALL RDAINPNLVQ TLGGTPALVH GGPFANIAHG CNSLIATTTA
310 320 330 340 350
LDLSEVVLTE AGFGSDLGAE KFFDIKSRAG DLDVAATVVV ATIRSLKHNG
360 370 380 390 400
DSVLKAGLAN LERHVSNIRK FGVEPVVALN LFSSDTAAER SMVADWGEQF
410 420 430 440 450
GVRVVECSVW AEGGAGAADL ATAVLEVVDG VSDEDASSSS HQIYQPVDGV
460 470 480 490 500
EATLHTLATE IYGAADVQFG PQALKDLAFL KDNGWDKLPV CVSKTQYSFS
510 520 530 540 550
DDPSALGAPS GHTLHVRELV PRIGAGFVVA LTGDVMTLPG LPKKPAAERI
560
DVNAQGVISG LF
Length:562
Mass (Da):58,634
Last modified:August 2, 2005 - v1
Checksum:i7CF7496392C041F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI37045.1.
RefSeqiWP_011273471.1. NC_007164.1.
YP_250663.1. NC_007164.1.

Genome annotation databases

EnsemblBacteriaiCAI37045; CAI37045; jk0881.
GeneIDi3432566.
KEGGicjk:jk0881.
PATRICi21512670. VBICorJei31838_0893.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI37045.1 .
RefSeqi WP_011273471.1. NC_007164.1.
YP_250663.1. NC_007164.1.

3D structure databases

ProteinModelPortali Q4JVW2.
SMRi Q4JVW2. Positions 14-560.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 306537.jk0881.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI37045 ; CAI37045 ; jk0881 .
GeneIDi 3432566.
KEGGi cjk:jk0881.
PATRICi 21512670. VBICorJei31838_0893.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi TWRRCLD.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CJEI306537:GJ8V-914-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
    Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
    J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K411.

Entry informationi

Entry nameiFTHS_CORJK
AccessioniPrimary (citable) accession number: Q4JVW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 2, 2005
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3