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Q4JVW2

- FTHS_CORJK

UniProt

Q4JVW2 - FTHS_CORJK

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi77 – 848ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCJEI306537:GJ8V-914-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:jk0881
    OrganismiCorynebacterium jeikeium (strain K411)
    Taxonomic identifieri306537 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000545: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Formate--tetrahydrofolate ligasePRO_0000199343Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi306537.jk0881.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4JVW2.
    SMRiQ4JVW2. Positions 14-560.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiTWRRCLD.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4JVW2-1 [UniParc]FASTAAdd to Basket

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    MTNSSATSNP QPSDVEIAQA HTLEPITTIA ERAGIPEAAL IPYGRTKAKI    50
    DVPALRAERE GVNKKGKLVL VTAMSPTPAG EGKSTVLIGL ADAVRTAGRQ 100
    TMVAIREPSQ GPVMGIKGGA AGGGYAQIVP MEDINLHFTG DMHAITAATN 150
    TLAAMVDNHV QHGNALGIDP RRVTWRRCLD VNDRSLRHVV TGLGGPGQGT 200
    PREGGFDITA ASEIMAILCL ATDLEDLKKR IGRIVVGQTY DRRPVTAGDL 250
    KCAGAITALL RDAINPNLVQ TLGGTPALVH GGPFANIAHG CNSLIATTTA 300
    LDLSEVVLTE AGFGSDLGAE KFFDIKSRAG DLDVAATVVV ATIRSLKHNG 350
    DSVLKAGLAN LERHVSNIRK FGVEPVVALN LFSSDTAAER SMVADWGEQF 400
    GVRVVECSVW AEGGAGAADL ATAVLEVVDG VSDEDASSSS HQIYQPVDGV 450
    EATLHTLATE IYGAADVQFG PQALKDLAFL KDNGWDKLPV CVSKTQYSFS 500
    DDPSALGAPS GHTLHVRELV PRIGAGFVVA LTGDVMTLPG LPKKPAAERI 550
    DVNAQGVISG LF 562
    Length:562
    Mass (Da):58,634
    Last modified:August 2, 2005 - v1
    Checksum:i7CF7496392C041F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR931997 Genomic DNA. Translation: CAI37045.1.
    RefSeqiYP_250663.1. NC_007164.1.

    Genome annotation databases

    EnsemblBacteriaiCAI37045; CAI37045; jk0881.
    GeneIDi3432566.
    KEGGicjk:jk0881.
    PATRICi21512670. VBICorJei31838_0893.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR931997 Genomic DNA. Translation: CAI37045.1 .
    RefSeqi YP_250663.1. NC_007164.1.

    3D structure databases

    ProteinModelPortali Q4JVW2.
    SMRi Q4JVW2. Positions 14-560.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 306537.jk0881.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI37045 ; CAI37045 ; jk0881 .
    GeneIDi 3432566.
    KEGGi cjk:jk0881.
    PATRICi 21512670. VBICorJei31838_0893.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi TWRRCLD.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CJEI306537:GJ8V-914-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
      Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
      J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K411.

    Entry informationi

    Entry nameiFTHS_CORJK
    AccessioniPrimary (citable) accession number: Q4JVW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3