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Protein

Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase

Gene

jk0900

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).By similarity

Catalytic activityi

4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate.
Oxaloacetate = pyruvate + CO2.

Cofactori

a divalent metal cationBy similarityNote: Divalent metal cation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei103SubstrateBy similarity1
Metal bindingi104Divalent metal cationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase (EC:4.1.3.17)
Short name:
HMG aldolase
Alternative name(s):
Oxaloacetate decarboxylase (EC:4.1.1.3)
Short name:
OAA decarboxylase
Regulator of ribonuclease activity homolog
RraA-like protein
Gene namesi
Ordered Locus Names:jk0900
OrganismiCorynebacterium jeikeium (strain K411)
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000545 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000138351 – 167Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolaseAdd BLAST167

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi306537.jk0900.

Structurei

3D structure databases

ProteinModelPortaliQ4JVU3.
SMRiQ4JVU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni81 – 84Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the class II aldolase/RraA-like family.Curated

Phylogenomic databases

eggNOGiENOG4108YYX. Bacteria.
COG0684. LUCA.
HOGENOMiHOG000252803.
KOiK02553.
OMAiRSCDTQF.
OrthoDBiPOG091H03SM.

Family and domain databases

CDDicd16841. RraA_family. 1 hit.
Gene3Di3.50.30.40. 1 hit.
InterProiView protein in InterPro
IPR010203. RraA.
IPR005493. RraA/RraA-like.
PfamiView protein in Pfam
PF03737. RraA-like. 1 hit.
SUPFAMiSSF89562. SSF89562. 1 hit.
TIGRFAMsiTIGR01935. NOT-MenG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4JVU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEKLTFIP TADLVDIIGS DVRSCDTQFR DLGGVVEFCG KITTVKCFQD
60 70 80 90 100
NALLKSVLQE DNPGGVLVID GDASMHTALV GDIIAGLGKD HGWAGVVING
110 120 130 140 150
PIRDSKVIGQ MEFGCKALGT NPRKSTKTGE GERDVTVSFG GVDFIPGEYI
160
YCDSDGIIVS DEIVQPV
Length:167
Mass (Da):17,709
Last modified:August 2, 2005 - v1
Checksum:iD7E72F26C5202617
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI37064.1.
RefSeqiWP_011273490.1. NC_007164.1.

Genome annotation databases

EnsemblBacteriaiCAI37064; CAI37064; jk0900.
GeneIDi3433299.
KEGGicjk:jk0900.

Similar proteinsi

Entry informationi

Entry nameiRRAAH_CORJK
AccessioniPrimary (citable) accession number: Q4JVU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 2, 2005
Last modified: August 30, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families