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Protein

Oxoglutarate dehydrogenase inhibitor

Gene

odhI

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

An essential component of the PknG signaling pathway. When unphosphorylated, it inhibits the activity of 2-oxoglutarate dehydrogenase. When phosphorylated it does not inhibit 2-oxoglutarate dehydrogenase (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Oxoglutarate dehydrogenase inhibitor
Gene namesi
Name:odhI
Ordered Locus Names:jk0903
OrganismiCorynebacterium jeikeium (strain K411)
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000545 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002729652 – 144Oxoglutarate dehydrogenase inhibitorAdd BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi306537.jk0903.

Structurei

3D structure databases

ProteinModelPortaliQ4JVU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 117FHAPROSITE-ProRule annotationAdd BLAST50

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108UW8. Bacteria.
COG1716. LUCA.
HOGENOMiHOG000242873.
OMAiNREPVDT.
OrthoDBiPOG091H09TV.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
IPR032030. YscD_cytoplasmic_dom.
[Graphical view]
PfamiPF16697. Yop-YscD_cpl. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4JVU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNTGVPEA SVETTSVFRA DLLKEMESGS QHDASPAGVE GLPEGSALLV
60 70 80 90 100
VKRGPNAGSR FLLDQETTAA GRHPDSDIFL DDVTVSRRHA EFRRNGDQYE
110 120 130 140
VVDVGSLNGT YVNREPKNSS VLSNGDEIQI GKFRLVFLNG SKEA
Length:144
Mass (Da):15,536
Last modified:August 2, 2005 - v1
Checksum:i88517200FC3946E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI37067.1.
RefSeqiWP_005294594.1. NC_007164.1.

Genome annotation databases

EnsemblBacteriaiCAI37067; CAI37067; jk0903.
GeneIDi3431851.
KEGGicjk:jk0903.
PATRICi21512716. VBICorJei31838_0915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI37067.1.
RefSeqiWP_005294594.1. NC_007164.1.

3D structure databases

ProteinModelPortaliQ4JVU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi306537.jk0903.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI37067; CAI37067; jk0903.
GeneIDi3431851.
KEGGicjk:jk0903.
PATRICi21512716. VBICorJei31838_0915.

Phylogenomic databases

eggNOGiENOG4108UW8. Bacteria.
COG1716. LUCA.
HOGENOMiHOG000242873.
OMAiNREPVDT.
OrthoDBiPOG091H09TV.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
IPR032030. YscD_cytoplasmic_dom.
[Graphical view]
PfamiPF16697. Yop-YscD_cpl. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiODHI_CORJK
AccessioniPrimary (citable) accession number: Q4JVU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: August 2, 2005
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.