Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q4JVT1 (Q4JVT1_CORJK) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Name:gnd EMBL CAI37076.1
Ordered Locus Names:jk0912
OrganismCorynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]
Taxonomic identifier306537 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding14 – 196NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding37 – 393NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding79 – 813NADP By similarity PIRSR PIRSR000109-3
Region133 – 1353Substrate binding By similarity PIRSR PIRSR000109-2
Region190 – 1912Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1871Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1941Proton donor By similarity PIRSR PIRSR000109-1
Binding site1071NADP By similarity PIRSR PIRSR000109-3
Binding site1071Substrate By similarity PIRSR PIRSR000109-2
Binding site1951Substrate By similarity PIRSR PIRSR000109-2
Binding site2651Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2921Substrate By similarity PIRSR PIRSR000109-2
Binding site4511Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4571Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q4JVT1 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 194536229885FF0C

FASTA48151,882
        10         20         30         40         50         60 
MTTAEGTAQI GVVGLAVMGS NIARNFANNG HTVAVYNRTT AKTDKFMEDF GETGNFVPSE 

        70         80         90        100        110        120 
TIADFVKSLE RPRRALIMVQ AGAGTDAVIS QLAEEMDEGD IIIDGGNALY TDTIRREAEM 

       130        140        150        160        170        180 
SERGLNFVGA GISGGEEGAL NGPAIMPGGP AESWEALGPL LESVAAKVDG TPCVTHIGPD 

       190        200        210        220        230        240 
GAGHFVKMVH NGIEYADMQV IGEAYQLLRY GAGMEPAEIA EVFKTWNEGD LDSYLIEITA 

       250        260        270        280        290        300 
EVLSQTDEKT GKPLIDVIVD SAGQKGTGRW TVKAALDLGI PTTGIGEAVF ARALSGAREQ 

       310        320        330        340        350        360 
RDATIGNLPS GELSTLDVPK EEFIEDVRRA LYASKLVAYA QGFDEIKAGS DEHKWGVDPR 

       370        380        390        400        410        420 
DLATIWRGGC IIRAKFLNRI REAYDANAEL PSLLLDPYFK GELGGLIDSW RRVVILATQL 

       430        440        450        460        470        480 
GQPVPVFASS LSYYDSLRAE RLPAALIQGQ RDYFGAHTYR RTDREGSFHT LWSGDRSEVE 


A

« Hide

References

[1]"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K411.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR931997 Genomic DNA. Translation: CAI37076.1.
RefSeqYP_250694.1. NC_007164.1.

3D structure databases

ProteinModelPortalQ4JVT1.
SMRQ4JVT1. Positions 8-473.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4JVT1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3433784.
GenomeReviewsGene locus jk0912 in contig CR931997_GR.
KEGGcjk:jk0912.
NMPDRfig|306537.3.peg.156.
PATRIC21512734. VBICorJei31838_0924.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0362.
HOGENOMHBG286913.
OMASNYPDTN.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ4JVT1_CORJK
AccessionPrimary (citable) accession number: Q4JVT1
Entry history
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info