Reviewed, UniProtKB/Swiss-Prot Q4JVN6 (UPPP2_CORJK)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2

Gene names

Name:	uppP2
Ordered Locus Names:	jk0957

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000227616
Regions
	Transmembrane	104 – 124	21	Potential
	Transmembrane	128 – 148	21	Potential
	Transmembrane	174 – 194	21	Potential
	Transmembrane	205 – 225	21	Potential
	Transmembrane	237 – 257	21	Potential
	Transmembrane	268 – 288	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4JVN6-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 7DEAAFF7CCAE65DD	FASTA	290	31,766
	10 20 30 40 50 60 MTTDMTWAQT IILSLIQGLT EFLPVSSSGH LRIFSTLLWG EDAGASFTAV IQLGTELAVL 70 80 90 100 110 120 VFFAKDIWNI ASAWCKGVWE WLTDLTGKHG RRVHRQSFDY RMGWMVIVGT LPVAVLGYLG 130 140 150 160 170 180 KDLIRDNLRN LWITATMLVL FSFVFILAER MGRRERSFDE LTMRDSVIMG FAQCLALIPG 190 200 210 220 230 240 VSRSGGTVSA GLFLNLDREV ATRYSFLLAI PAVLASGLFS LPDAFSPDAG QAASGAQLFV 250 260 270 280 290 GTAIAFAVGY ASIAWLLKFV ANHSFAWFAL WRIPLGLAVM GLLAFGVLQA

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR931997 Genomic DNA. Translation: CAI37121.1.
RefSeq	YP_250739.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3433525.
GenomeReviews	Gene locus jk0957 in contig CR931997_GR.
KEGG	cjk:jk0957.
NMPDR	fig|306537.3.peg.417.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4JVN6.
OMA	Q4JVN6. RYISTRT.
Enzyme and pathway databases
BioCyc	CJEI306537:JK0957-MON.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_CORJK

Accession

Primary (citable) accession number: Q4JVN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	August 2, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)