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Q4JVN6 (UPPP2_CORJK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 2

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene names
Name:uppP2
Ordered Locus Names:jk0957
OrganismCorynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]
Taxonomic identifier306537 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Undecaprenyl-diphosphatase 2 HAMAP-Rule MF_01006
PRO_0000227616

Regions

Transmembrane104 – 12421Helical; Potential
Transmembrane128 – 14821Helical; Potential
Transmembrane174 – 19421Helical; Potential
Transmembrane205 – 22521Helical; Potential
Transmembrane237 – 25721Helical; Potential
Transmembrane268 – 28821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q4JVN6 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 7DEAAFF7CCAE65DD

FASTA29031,766
        10         20         30         40         50         60 
MTTDMTWAQT IILSLIQGLT EFLPVSSSGH LRIFSTLLWG EDAGASFTAV IQLGTELAVL 

        70         80         90        100        110        120 
VFFAKDIWNI ASAWCKGVWE WLTDLTGKHG RRVHRQSFDY RMGWMVIVGT LPVAVLGYLG 

       130        140        150        160        170        180 
KDLIRDNLRN LWITATMLVL FSFVFILAER MGRRERSFDE LTMRDSVIMG FAQCLALIPG 

       190        200        210        220        230        240 
VSRSGGTVSA GLFLNLDREV ATRYSFLLAI PAVLASGLFS LPDAFSPDAG QAASGAQLFV 

       250        260        270        280        290 
GTAIAFAVGY ASIAWLLKFV ANHSFAWFAL WRIPLGLAVM GLLAFGVLQA 

« Hide

References

[1]"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K411.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR931997 Genomic DNA. Translation: CAI37121.1.
RefSeqYP_250739.1. NC_007164.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING306537.jk0957.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI37121; CAI37121; jk0957.
GeneID3433525.
KEGGcjk:jk0957.
PATRIC21512822. VBICorJei31838_0968.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAIWNIASA.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycCJEI306537:GJ8V-991-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP2_CORJK
AccessionPrimary (citable) accession number: Q4JVN6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 2, 2005
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families