Reviewed, UniProtKB/Swiss-Prot Q4JVH4 (KGUA_CORJK)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	jk1019

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity HAMAP MF_00328.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Guanylate kinase HAMAP MF_00328		PRO_0000266311
Regions
	Domain	8 – 188	181	Guanylate kinase-like
	Nucleotide binding	15 – 22	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4JVH4-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: FEBB9D9FF77683C6	FASTA	188	20,915
	10 20 30 40 50 60 MSQDLNSGRI VVLAGPSAVG KSTVVRRLRT DVPDLFFSVS MTTRDPRPGE VDGEDYIYVT 70 80 90 100 110 120 REQFEQNIAA DKMLEWAEIH GGLQLSGTPR EPIEKALAES RPVLVEVDLE GARNVKKMLP 130 140 150 160 170 180 QVQTVFLAPP SWEELVDRLT GRGTETQDVI ERRLQTAKVE MASQSEFDHV VVNDDVDKAV AAISEILR

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR931997 Genomic DNA. Translation: CAI37183.1.
RefSeq	YP_250801.1.
3D structure databases
HSSP	HSSP built from PDB template 1ZNW based on UniProtKB P0A5I4.
SMR	Q4JVH4. Positions 8-187.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JVH4.
Genome annotation databases
GeneID	3433783.
GenomeReviews	Gene locus jk1019 in contig CR931997_GR.
KEGG	cjk:jk1019.
NMPDR	fig|306537.3.peg.714.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
HOGENOM	HBG671982.
OMA	DIDWQGT.
Enzyme and pathway databases
BioCyc	CJEI306537:JK1019-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_CORJK

Accession

Primary (citable) accession number: Q4JVH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	August 2, 2005
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)