Q4JVG9 (Q4JVG9_CORJK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydroorotase RuleBase RU003441
EC=3.5.2.3 RuleBase RU003441

Gene names

Name:	pyrC EMBL CAI37188.1
Ordered Locus Names:	jk1024

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. RuleBase RU003441 SAAS SAAS002195
Cofactor	Binds 2 zinc ions per subunit By similarity. RuleBase RU003441 SAAS SAAS002195
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. RuleBase RU003441 SAAS SAAS002195
Subunit structure	Homodimer By similarity. SAAS SAAS002195
Sequence similarities	Belongs to the DHOase family. Type 2 subfamily. RuleBase RU003441

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis RuleBase RU003441 SAAS SAAS002195
Ligand	Metal-binding SAAS SAAS002195 RuleBase RU003441 Zinc RuleBase RU003441 SAAS SAAS002195
Molecular function	Hydrolase RuleBase RU003441 SAAS SAAS002195 EMBL CAI37188.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	dihydroorotase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4JVG9 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 3466DFAB63D3FEAC	FASTA	466	50,118
	10 20 30 40 50 60 MAQTDKKTFD EGALTMTSEY PATGELAGHP TGAEHAVLLR GVLLYGEGEK QDVLIQDGVI 70 80 90 100 110 120 AEIGADLADS APQGAEVLDL DGQVLLPGLV DMHVHLREPG REDTETIATG SAAAAQGGFT 130 140 150 160 170 180 AVFTMANTAP VTDNPAIAEM VWFKGQNTNL CDVHPVGSIS KGLEGKELTE FGMMADSDAK 190 200 210 220 230 240 VRMFSDDGKC VDDPRLMRRA IEYSKGMDVL LAQHCEEPRL TEGAVAHEGE TAARLGLGGW 250 260 270 280 290 300 PRVAEESIVA RDAIMARDYG GRLHICHAST EGTVELLRWV KDQDIPLSAE VTPHHLLLTD 310 320 330 340 350 360 ARLETYDGVN RVNPPLREQR DVEALRAALI DGTVDCVATD HAPHGSEDKC CEFDQARPGM 370 380 390 400 410 420 LGIETSLALI AKIFVIDGDE DWRFVAKVMS ERPAEITKLP GHGRPIAVGE PANLCAVDLN 430 440 450 460 QKWTAHGKDM ASKANNTPYE GMEMPVKVTT TLLRGKVTCK NGSAVK

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K411.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR931997 Genomic DNA. Translation: CAI37188.1.
RefSeq	YP_250806.1. NC_007164.1.
3D structure databases
ProteinModelPortal	Q4JVG9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4JVG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3431914.
GenomeReviews	Gene locus jk1024 in contig CR931997_GR.
KEGG	cjk:jk1024.
NMPDR	fig|306537.3.peg.719.
PATRIC	21512960. VBICorJei31838_1036.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0044.
HOGENOM	HBG724623.
OMA	CDVHPVG.
ProtClustDB	PRK09357.
Family and domain databases
HAMAP	MF_00220_B. PyrC_type2_B. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR004722. DHOase. IPR002195. Dihydroorotase_CS. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
KO	K01465.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMs	TIGR00857. PyrC_multi. 1 hit.
PROSITE	PS00482. DIHYDROOROTASE_1. 1 hit. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q4JVG9_CORJK

Accession

Primary (citable) accession number: Q4JVG9

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)