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Q4JVB8 (Q4JVB8_CORJK) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase HAMAP MF_00218
Short name=UPD HAMAP MF_00218
Short name=URO-D HAMAP MF_00218
EC=4.1.1.37 HAMAP MF_00218
Gene names
Name:hemE HAMAP MF_00218 EMBL CAI37239.1
Ordered Locus Names:jk1075
OrganismCorynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]
Taxonomic identifier306537 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218 SAAS SAAS006361

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218 RuleBase RU000554 SAAS SAAS006361

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen III from 5-aminolevulinate: step 4/4. RuleBase RU000554

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218 SAAS SAAS006361

Subunit structure

Homodimer By similarity. HAMAP MF_00218 SAAS SAAS006361

Subcellular location

Cytoplasm By similarity HAMAP MF_00218 SAAS SAAS006361.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family. HAMAP MF_00218 RuleBase RU004169

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region50 – 545Substrate binding By similarity HAMAP MF_00218

Sites

Binding site991Substrate By similarity HAMAP MF_00218
Binding site1751Substrate By similarity HAMAP MF_00218
Binding site2301Substrate By similarity HAMAP MF_00218
Binding site3641Substrate By similarity HAMAP MF_00218
Site991Transition state stabilizer By similarity HAMAP MF_00218

Sequences

Sequence LengthMass (Da)Tools
Q4JVB8 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: AF21C76BC5618CB1

FASTA38541,878
        10         20         30         40         50         60 
MATMTSEPND CPIQADTAAA EARRRAHKDA PFLAAARGET PSRRPVWMMR QAGRSLPEYR 

        70         80         90        100        110        120 
EIRKDYGMLE SCFNPELLAE ITLQPVRRHD ADAAILFSDI VVPLKAAGVD LDIVAGRGPV 

       130        140        150        160        170        180 
VEHPVRTAEE VTALPIVESS QLDSIVEGIG GVLQGLRDDQ VLIGFAGAPF TLASYLVEGG 

       190        200        210        220        230        240 
PSKNHEVTKA LMYSQPDVWH ALMRRLTPTI IRFLQVQAEA GVDALQLFDS WAGYLTARDY 

       250        260        270        280        290        300 
REFVRPYSTQ IFDAMRAYGI PMIHFGVGTG ELLGDMALAG PDVVGVDWRV PLDSAATRVS 

       310        320        330        340        350        360 
AALQEADPTA EPTARAKALQ GNLDPAVLFA GPEVVETQIA RICAEADRAI ERGQARGHIF 

       370        380 
NLGHGVLPNT DPDAITRAFE EVHKR

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References

[1]"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
J. Bacteriol. 187:4671-4682(2005) [PubMed: 15968079] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K411.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR931997 Genomic DNA. Translation: CAI37239.1.
RefSeqYP_250857.1. NC_007164.1.

3D structure databases

ProteinModelPortalQ4JVB8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4JVB8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3433170.
GenomeReviewsGene locus jk1075 in contig CR931997_GR.
KEGGcjk:jk1075.
NMPDRfig|306537.3.peg.998.
PATRIC21513076. VBICorJei31838_1087.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHBG628392.
OMAPRIHFGV.
ProtClustDBPRK00115.

Family and domain databases

HAMAPMF_00218. URO_D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ4JVB8_CORJK
AccessionPrimary (citable) accession number: Q4JVB8
Entry history
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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