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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi555MagnesiumUniRule annotation1
Metal bindingi561MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:jk1132
OrganismiCorynebacterium jeikeium (strain K411)
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000545 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003296111 – 764Polyribonucleotide nucleotidyltransferaseAdd BLAST764

Proteomic databases

PRIDEiQ4JV61.

Interactioni

Protein-protein interaction databases

STRINGi306537.jk1132.

Structurei

3D structure databases

ProteinModelPortaliQ4JV61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini621 – 680KHUniRule annotationAdd BLAST60
Domaini692 – 761S1 motifUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 2 hits.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4JV61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKKQNIQA ELVDPDAGVW EVEATIDNGD FGTRSIRFET GLLARQADGA
60 70 80 90 100
VTAYLDEDTM LLSTTAASRQ PREGIDFFPL TVDVEERMYS VGRIPGSFFR
110 120 130 140 150
REGRPGTDAI LAARLIDRPL RPTFVRGLRN EVQVIVTVLS MDPKDRYDVL
160 170 180 190 200
AINGASASTQ LSGLPVSGPV GGVRMALVVD SDHPEGQWVA FPTREQEEKA
210 220 230 240 250
IFELVVAGRV TEPVKPARGR GRGRGKGAGS SEPNVAVMMV EAGATDNVVE
260 270 280 290 300
RIAEGAPAPT EEVVAQGIEA AKPFIATLCE AQNALAKAVD AETREFELFP
310 320 330 340 350
PYGEDVFASV QAEALDALED IMAIADKQER DEALAANMQA NVDELLPEFP
360 370 380 390 400
EREAEIRAAH NEVTKAVVRR RILEDGFRID GRDSTTIRDL GIVVQLIPRA
410 420 430 440 450
HGSALFERGE TQILGVTTLD MLKMEQQIDS LGPETSKRYI HHYNFPPYST
460 470 480 490 500
GETGRVGSPK RREIGHGALA ERALTPVIPS RDDFPYTIRQ VSEALSSNGS
510 520 530 540 550
TSMGSVCAST LSLYNAGVPL KAPVAGIAMG LVTGKVGKAG KDKYVTLTDI
560 570 580 590 600
LGAEDAFGDM DFKVAGTPDF VTALQLDTKL DGIPSDVLAE ALQQARTARL
610 620 630 640 650
EILQLMEEAI DSPDDMSDLA PHITSINIPQ NKIGEVIGPK GKTINQITEE
660 670 680 690 700
TGANITIEDD GTVFISAVGG ESAREAEEKI NAIANPQQPK VGDRFLGTVV
710 720 730 740 750
KTTAFGAFVS LLPGRDGLIH ISNLGGDRRI ERVEDEVSVG DKLEVEIADI
760
DNRGKISLVL VEEN
Length:764
Mass (Da):82,255
Last modified:August 2, 2005 - v1
Checksum:i97207D6EBCB43932
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI37296.1.
RefSeqiWP_011273674.1. NC_007164.1.

Genome annotation databases

EnsemblBacteriaiCAI37296; CAI37296; jk1132.
GeneIDi3432593.
KEGGicjk:jk1132.
PATRICi21513192. VBICorJei31838_1145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA. Translation: CAI37296.1.
RefSeqiWP_011273674.1. NC_007164.1.

3D structure databases

ProteinModelPortaliQ4JV61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi306537.jk1132.

Proteomic databases

PRIDEiQ4JV61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI37296; CAI37296; jk1132.
GeneIDi3432593.
KEGGicjk:jk1132.
PATRICi21513192. VBICorJei31838_1145.

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 2 hits.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPNP_CORJK
AccessioniPrimary (citable) accession number: Q4JV61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 2, 2005
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.