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Q4JUX6 (DDL_CORJK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:jk1217
OrganismCorynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]
Taxonomic identifier306537 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341086

Regions

Domain165 – 369205ATP-grasp
Nucleotide binding192 – 24756ATP By similarity

Sites

Metal binding3241Magnesium or manganese 1 By similarity
Metal binding3361Magnesium or manganese 1 By similarity
Metal binding3361Magnesium or manganese 2 By similarity
Metal binding3381Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4JUX6 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: CE68144B565BE606

FASTA37338,958
        10         20         30         40         50         60 
MSNEAKKHAR TTVAVLYGGQ STEHSVSCIS AGAVIDHLDP EIYEVVPVGI TEAGAWVPGT 

        70         80         90        100        110        120 
TDTSRLRADG RDMPRVEDGG VHVQLTFGGA GTAGSAGSGA AGEMRYVTGP QAGEVFAQVD 

       130        140        150        160        170        180 
VVFPVLHGVN GEDGTVQGVL DLAGVRYVGN GVLASAAGMD KDFTKRLARE AGIPVGEELI 

       190        200        210        220        230        240 
LFQPRELTAE EKERLGLPVF VKPARGGSSI GISKVDSWEE FDAAIDLAFS NDNKVIVEAM 

       250        260        270        280        290        300 
IHGAEVECGV LQHADGSIVS SVPAMLNGTE DGAEGFYGFD AKYVDSTVSA TIPAPLPAET 

       310        320        330        340        350        360 
IKEIRQLAIR TFNALGCDGI ARVDFFATEN GPVLNEINTM PGFTPISMYP KMFAAEGVSF 

       370 
GDLVSALIAR ALA 

« Hide

References

[1]"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K411.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR931997 Genomic DNA. Translation: CAI37381.1.
RefSeqYP_250999.1. NC_007164.1.

3D structure databases

ProteinModelPortalQ4JUX6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING306537.jk1217.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI37381; CAI37381; jk1217.
GeneID3433693.
KEGGcjk:jk1217.
PATRIC21513366. VBICorJei31838_1232.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK01966.

Enzyme and pathway databases

BioCycCJEI306537:GJ8V-1259-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_CORJK
AccessionPrimary (citable) accession number: Q4JUX6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 2, 2005
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways