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Q4JUN9 (ILVC_CORJK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase

EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:jk1298
OrganismCorynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]
Taxonomic identifier306537 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP-Rule MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP-Rule MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Ketol-acid reductoisomerase HAMAP-Rule MF_00435
PRO_0000226172

Sites

Active site1091 Potential

Sequences

Sequence LengthMass (Da)Tools
Q4JUN9 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: C3615775C35B4099

FASTA33836,640
        10         20         30         40         50         60 
MAIDVFYDDD ADLSIIQGRK VAIIGYGSQG HAHAQNLRES GVEVVIGLRE GSKSRAKAEE 

        70         80         90        100        110        120 
AGFTVKTNAE AAEWADVIML LAPDTSQAKI FAEDIEPNLN DGDALFFGHG LNIHFKLIEP 

       130        140        150        160        170        180 
ADNIIIGMVA PKGPGHLVRR QFVDGKGVPC LIAVEQDPKN NGRDLALSYA AAIGGARAGV 

       190        200        210        220        230        240 
IPTTFEAETV TDLFGEQAVL CGGTEELIKT GFEVLVEAGY EPEMAYFECL HEMKLIVDLM 

       250        260        270        280        290        300 
FEGGIANMNY SVSDTAEFGG YLSGPRVIDA DTKKRMKDIL TDIQDGTFTK RLVANVEGGN 

       310        320        330 
KELEELRASY NDHQIEKTGA KLRDLMSWVK VDARAETA 

« Hide

References

[1]"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora."
Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.
J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K411.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR931997 Genomic DNA. Translation: CAI37468.1.
RefSeqYP_251086.1. NC_007164.1.

3D structure databases

ProteinModelPortalQ4JUN9.
SMRQ4JUN9. Positions 3-329.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING306537.jk1298.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI37468; CAI37468; jk1298.
GeneID3432448.
KEGGcjk:jk1298.
PATRIC21513538. VBICorJei31838_1317.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHOG000016230.
KOK00053.
OMAEWILENQ.
OrthoDBEOG625K07.
ProtClustDBPRK05479.

Enzyme and pathway databases

BioCycCJEI306537:GJ8V-1343-MONOMER.
UniPathwayUPA00047; UER00056.
UPA00049; UER00060.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
HAMAPMF_00435. IlvC.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERPTHR21371. PTHR21371. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00465. ilvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_CORJK
AccessionPrimary (citable) accession number: Q4JUN9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: August 2, 2005
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways