ID   KHSE_CORJK              Reviewed;         308 AA.
AC   Q4JUI5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=Homoserine kinase;
DE            Short=HSK;
DE            Short=HK;
DE            EC=2.7.1.39;
GN   Name=thrB; OrderedLocusNames=jk1350;
OS   Corynebacterium jeikeium (strain K411).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Corynebacteriaceae; Corynebacterium.
OX   NCBI_TaxID=306537;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15968079; DOI=10.1128/JB.187.13.4671-4682.2005;
RA   Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B.,
RA   Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T.,
RA   Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P.,
RA   Puehler A.;
RT   "Complete genome sequence and analysis of the multiresistant
RT   nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring
RT   bacterium of the human skin flora.";
RL   J. Bacteriol. 187:4671-4682(2005).
CC   -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC       homoserine.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 4/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Homoserine kinase
CC       subfamily.
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DR   EMBL; CR931997; CAI37522.1; -; Genomic_DNA.
DR   RefSeq; YP_251140.1; -.
DR   GeneID; 3433261; -.
DR   GenomeReviews; CR931997_GR; jk1350.
DR   KEGG; cjk:jk1350; -.
DR   NMPDR; fig|306537.3.peg.55; -.
DR   HOGENOM; Q4JUI5; -.
DR   OMA; Q4JUI5; FDCLGAA.
DR   BioCyc; CJEI306537:JK1350-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:HAMAP.
DR   GO; GO:0016310; P:phosphorylation; IEA:InterPro.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00384; -; 1.
DR   InterPro; IPR006204; GHMP_kinase.
DR   InterPro; IPR013750; GHMP_kinase_C.
DR   InterPro; IPR006203; GHMP_knse_ATP_bd_CS.
DR   InterPro; IPR000870; Homoserine_kin.
DR   InterPro; IPR014721; Ribosomal_S5_D2-type_fold.
DR   Gene3D; G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000676; Homoser_kin; 1.
DR   PRINTS; PR00958; HOMSERKINASE.
DR   TIGRFAMs; TIGR00191; thrB; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm;
KW   Kinase; Nucleotide-binding; Threonine biosynthesis; Transferase.
FT   CHAIN         1    308       Homoserine kinase.
FT                                /FTId=PRO_1000049127.
FT   NP_BIND      95    105       ATP (Potential).
SQ   SEQUENCE   308 AA;  32330 MW;  C280075DBAC230C7 CRC64;
     MGVEIPVGRK ATVKVPASTA NLGPGFDTLG LALGLYDYVT AEVIESGLEV EVTGEGEGEV
     PLDERHLVVR ALRATLKEAD VTVPGLRVSC TNSIPQSRGL GSSAAAATAG VAAGNGLAGF
     TLDDQAQVQI ASTFEGHPDN AGASVLGAGV VSWTNTPIDG VSAPAYHARR IDVHPDIKAT
     AFIPDFHAST EAIRRVLPSD ISHVDARFNV SRTAVMTVAL RDDPDLLWEG TRDRMHQTYR
     AEVLPVTAEW VNRLRNLGYP AFLSGAGPTI LVLSTEPVDN ALVEEARGRG MKVLELGIAG
     PVEVDVTG
//