Q4JUI1 (SYR_CORJK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	jk1354

Organism

Corynebacterium jeikeium (strain K411) [Complete proteome] [HAMAP]

Taxonomic identifier

306537 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium › Corynebacterium jeikeium

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.
Sequence caution	The sequence CAI37526.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 556	556	Arginine--tRNA ligase HAMAP-Rule MF_00123		PRO_0000242010
Regions
	Motif	130 – 140	11	"HIGH" region HAMAP-Rule MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q4JUI1 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 81C7B91329D71D1E	FASTA	556	60,134
	10 20 30 40 50 60 MTPAELSELI TETARTTLDA HGLDSSVVPE SATVERPRNP EHGDYATNIA MQVAKKAGTN 70 80 90 100 110 120 PREFGTWLAE SLGAHEGIDE ATVAGPGFIN IRLAAAAQGK IVEDILTVGA NFGHGDELAG 130 140 150 160 170 180 AAINLEFVSA NPTGPIHLGG TRWAAVGDSL GRVLNARGAK VTREYYFNDH GAQIDRFARS 190 200 210 220 230 240 LVAAAKGEPT PEDGYGGDYI QDIASQIVEA NPDWQKLGAD EAQELFRSQG VELMFAHIKR 250 260 270 280 290 300 TLAEFGTEFD VYFHENSLFE SGAVEAAIQK IKDNGNLYEA DGAWWLRSTN FGDDKDRVVI 310 320 330 340 350 360 KSDGNAAYIA GDIAYVADKF DRGHNLCIYM LGADHHGYIA RLRAAAAAMG YDPQQVEVLI 370 380 390 400 410 420 GQLVNLVKDG KAVRMSKRAG TVITLDDLVE AIGVDAARYA MIRSSVDSSL DIDMDLWASK 430 440 450 460 470 480 SNDNPVFYVQ YAHARLCSLA RKAEDLGVTR EGADLSLLTH DREGDLIRTL GEFPAVVKTA 490 500 510 520 530 540 AELREPHRVA RYAESLAGTF HRFYDACQIL PKPSDDEQTV AENKALFAAR LSLAAASRQT 550 LANALELLGV AAPERM

References

[1]

"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora." Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A. J. Bacteriol. 187:4671-4682(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K411.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR931997 Genomic DNA. Translation: CAI37526.1. Different initiation.
RefSeq	YP_251144.1. NC_007164.1.
3D structure databases
ProteinModelPortal	Q4JUI1.
ModBase	Search...
Protein-protein interaction databases
STRING	306537.jk1354.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAI37526; CAI37526; jk1354.
GeneID	3432219.
KEGG	cjk:jk1354.
PATRIC	21513652. VBICorJei31838_1374.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HOG000247214.
KO	K01887.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	CJEI306537:GJ8V-1399-MONOMER.
Family and domain databases
Gene3D	3.30.1360.70. 1 hit. 3.40.50.620. 1 hit.
HAMAP	MF_00123. Arg_tRNA_synth.
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
PANTHER	PTHR11956. PTHR11956. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_CORJK

Accession

Primary (citable) accession number: Q4JUI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	May 1, 2013
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program