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Protein

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase

Gene

mshB

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi18ZincUniRule annotation1
Metal bindingi21ZincUniRule annotation1
Metal bindingi165ZincUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseUniRule annotation (EC:3.5.1.103UniRule annotation)
Short name:
GlcNAc-Ins deacetylaseUniRule annotation
Alternative name(s):
N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Gene namesi
Name:mshBUniRule annotation
Ordered Locus Names:jk1397
OrganismiCorynebacterium jeikeium (strain K411)
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000545 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001801 – 3331D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseAdd BLAST333

Interactioni

Protein-protein interaction databases

STRINGi306537.jk1397

Structurei

3D structure databases

ProteinModelPortaliQ4JUD7
SMRiQ4JUD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MshB deacetylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2120 LUCA
HOGENOMiHOG000241173
KOiK15525
OMAiKFYWTVT
OrthoDBiPOG091H08W5

Family and domain databases

Gene3Di3.40.50.10320, 1 hit
HAMAPiMF_01696 MshB, 1 hit
InterProiView protein in InterPro
IPR003737 GlcNAc_PI_deacetylase-related
IPR024078 LmbE-like_dom_sf
IPR017810 Mycothiol_biosynthesis_MshB
PANTHERiPTHR12993 PTHR12993, 1 hit
PfamiView protein in Pfam
PF02585 PIG-L, 1 hit
SUPFAMiSSF102588 SSF102588, 1 hit
TIGRFAMsiTIGR03445 mycothiol_MshB, 1 hit

Sequencei

Sequence statusi: Complete.

Q4JUD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTPAEAKI TVMAVHAHPD DETLWTGLAL AKARRLGHDV AVVTCTLGEE
60 70 80 90 100
GEVIGEKYQA LVDAQQYEQG TGMLGGYRIA ELQRALGALG VQHGPNFLGG
110 120 130 140 150
CGTWRDSGME GSESIRHPRA FAREVEPAQD LLDAQVEQLI QQIQSIRPEV
160 170 180 190 200
ILTYAADGGY GHPDHKQAHR IVHEAVQRLS GASAEGAGAD VFVPSQVLWC
210 220 230 240 250
VTEDEKFAKG MQGLEDDPTA VPEGWTLPAA GEIATVPSAE VDLVIHGSAE
260 270 280 290 300
DVAAKQAAMR AHATQIWVAD GTASDVNAQV RESNPPAPSA TTLFCLSNLI
310 320 330
TQPLLDSESY RLGWTAPGVP EDFFARALAE QMV
Length:333
Mass (Da):35,520
Last modified:August 2, 2005 - v1
Checksum:i54E718E8124FB560
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA Translation: CAI37570.1
RefSeqiWP_011273861.1, NC_007164.1

Genome annotation databases

EnsemblBacteriaiCAI37570; CAI37570; jk1397
GeneIDi3432665
KEGGicjk:jk1397
PATRICifig|306537.10.peg.1417

Similar proteinsi

Entry informationi

Entry nameiMSHB_CORJK
AccessioniPrimary (citable) accession number: Q4JUD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: August 2, 2005
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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